Component
MCF7 breast cancer cell cycle progression
MCF7 breast cancer cell cycle progression. Species, exposure and limitations are retained in each linked claim.
1 recorded relationships. Experimental role, claim status and evidence remain attached to each record.
How nutrients influence it
Every nutrient with a recorded effect on this component, credited to the nutrient that acted rather than the chapter that recorded it. Open a nutrient to see the findings and the conditions they were measured under.
Other things that act on it
Enzymes, hormones, genes, and other components with a recorded effect. These are not nutrients, so they do not count toward the arrows above. Each finding names the chapter that recorded it.
How nutrients reach it in more than one step
Chains of two or more recorded steps that end here, grouped by the nutrient they start from. Each step is a separate finding, so a chain is a route a mechanism could take, not proof that it does.
Tracing routes…
What it does
Every recorded relationship this component is part of, grouped by its role. Plain wording comes first; the technical statement follows.
What acts on it
Lycopene delayed cell-cycle progression without accompanying apoptotic or necrotic cell death in the tested MCF7 cultures.
Experimental context and source evidence
- evidence_span
- {"source_cache": "artifacts/lycopene-research/10798222.abstract.txt", "locator": "Primary indexed abstract; zero-based, end-exclusive Unicode character offsets", "file_sha256": "f9229468bbed86c3c4fdbb24f80d139f5cac41e1692195090d19a195bcd144e8", "start_char": 0, "end_char": 1731, "text_sha256": "f9229468bbed86c3c4fdbb24f80d139f5cac41e1692195090d19a195bcd144e8"}
- experimental_model
- Growth-factor stimulation and signaling assays
- exposure
- IGF-I stimulation with lycopene exposure
- limitations
- Cell-line mechanism; not proof of lowered human serum IGF-I or cancer treatment.
- nutrient_topic
- Lycopene research collection; topical membership is not evidence of a direct dietary effect. · Lycopene
- organism
- Human MCF7 breast cancer cells
- plain_language
- Slower growth was distinguished from simply killing the cells.
- primary_references
- [lycopene-p10798222] Lycopene interferes with cell cycle progression and insulin-like growth factor I signaling in mammary cancer cells. (2000). https://pubmed.ncbi.nlm.nih.gov/10798222/ DOI: 10.1207/s15327914nc3601_14
- tissue_or_cell_type
- IRS1 phosphorylation, AP-1 and cell cycle
Lycopene: absorption, metabolism, nutrient connections and human outcomes (2026-09-17) · lines 702–713
AI-assisted literature curation; primary study URLs and scope retained in the document and extraction. Not publisher full text. · supports · Growth-factor stimulation and signaling assays · source_derived_draft · unverified_draft
### lycopene-cell-cycle Lycopene delayed cell-cycle progression without accompanying apoptotic or necrotic cell death in the tested MCF7 cultures. Condition category: normal nutrient_topic: Lycopene research collection; topical membership is not evidence of a direct dietary effect. plain_language: Slower growth was distinguished from simply killing the cells. organism: Human MCF7 breast cancer cells tissue_or_cell_type: IRS1 phosphorylation, AP-1 and cell cycle experimental_model: Growth-factor stimulation and signaling assays limitations: Cell-line mechanism; not proof of lowered human serum IGF-I or cancer treatment. exposure: IGF-I stimulation with lycopene exposure evidence_span: {"source_cache": "artifacts/lycopene-research/10798222.abstract.txt", "locator": "Primary indexed abstract; zero-based, end-exclusive Unicode character offsets", "file_sha256": "f9229468bbed86c3c4fdbb24f80d139f5cac41e1692195090d19a195bcd144e8", "start_char": 0, "end_char": 1731, "text_sha256": "f9229468bbed86c3c4fdbb24f80d139f5cac41e1692195090d19a195bcd144e8"} [lycopene-p10798222] Lycopene interferes with cell cycle progression and insulin-like growth factor I signaling in mammary cancer cells. (2000). https://pubmed.ncbi.nlm.nih.gov/10798222/ DOI: 10.1207/s15327914nc3601_14
Complete structured claim and evidence
The events it takes part in
A mechanism often involves more than two components. These are the full events, with every participant and its role.
Situations it appears in
Low-supply and faulty-machinery situations recorded in the chapters where this component plays a part.
In the sources
Preserved passages that mention this component, quoted exactly. Open one to read it in context.
Open hypotheses
Proposed ideas that involve this component. They are labeled as hypotheses and do not change any recorded statement.
This is a research prototype built from draft material. It is not medical advice, and its statements still await verification against the original studies.