Component
Brachial flow-mediated to nitroglycerin-mediated dilation ratio
Brachial flow-mediated to nitroglycerin-mediated dilation ratio. Species, exposure and limitations are retained in each linked claim.
1 recorded relationships. Experimental role, claim status and evidence remain attached to each record.
How nutrients influence it
Every nutrient with a recorded effect on this component, credited to the nutrient that acted rather than the chapter that recorded it. Open a nutrient to see the findings and the conditions they were measured under.
Other things that act on it
Enzymes, hormones, genes, and other components with a recorded effect. These are not nutrients, so they do not count toward the arrows above. Each finding names the chapter that recorded it.
How nutrients reach it in more than one step
Chains of two or more recorded steps that end here, grouped by the nutrient they start from. Each step is a separate finding, so a chain is a route a mechanism could take, not proof that it does.
Tracing routes…
What it does
Every recorded relationship this component is part of, grouped by its role. Plain wording comes first; the technical statement follows.
What acts on it
The FMD/NMD ratio increased by 0.12 with citrulline versus 0.01 with placebo in the CAD trial.
Experimental context and source evidence
- evidence_span
- {"source_cache": "artifacts/citrulline-research/27648629.abstract.txt", "locator": "Primary indexed abstract; zero-based, end-exclusive Unicode character offsets", "file_sha256": "7584e325856443da6067298d1c6ab31b95679839361f4a60adc5f7434944fb17", "start_char": 0, "end_char": 1848, "text_sha256": "7584e325856443da6067298d1c6ab31b95679839361f4a60adc5f7434944fb17"}
- experimental_model
- Randomized placebo crossover vascular trial
- exposure
- Fifteen-day L-citrulline and placebo periods
- limitations
- Small surrogate trial; abstract reports unusual FMD units, so only the dimensionless ratio is extracted.
- nutrient_topic
- Citrulline research collection; topical membership is not evidence of a direct dietary effect. · L-Citrulline
- organism
- Human, 30 coronary-artery-disease patients
- plain_language
- A vascular-response ratio improved in this selected patient group.
- primary_references
- [citrulline-p27648629] The Assessment of short-term effect of L-Citrulline on endothelial function via FMD to NMD ratio in known CAD patients: A randomized, cross-over clinical trial (Clinical trial number: NCT02638727). (2017). https://pubmed.ncbi.nlm.nih.gov/27648629/ DOI: 10.1515/rjim-2016-0045
- tissue_or_cell_type
- Brachial FMD/NMD ratio
Citrulline: arginine recycling, nitrogen disposal and nutrient connections (2026-09-17) · lines 1230–1241
AI-assisted literature curation; primary study URLs and scope retained in the document and extraction. Not publisher full text. · supports · Randomized placebo crossover vascular trial · source_derived_draft · unverified_draft
### citrulline-cad-ratio The FMD/NMD ratio increased by 0.12 with citrulline versus 0.01 with placebo in the CAD trial. Condition category: normal nutrient_topic: Citrulline research collection; topical membership is not evidence of a direct dietary effect. plain_language: A vascular-response ratio improved in this selected patient group. organism: Human, 30 coronary-artery-disease patients tissue_or_cell_type: Brachial FMD/NMD ratio experimental_model: Randomized placebo crossover vascular trial limitations: Small surrogate trial; abstract reports unusual FMD units, so only the dimensionless ratio is extracted. exposure: Fifteen-day L-citrulline and placebo periods evidence_span: {"source_cache": "artifacts/citrulline-research/27648629.abstract.txt", "locator": "Primary indexed abstract; zero-based, end-exclusive Unicode character offsets", "file_sha256": "7584e325856443da6067298d1c6ab31b95679839361f4a60adc5f7434944fb17", "start_char": 0, "end_char": 1848, "text_sha256": "7584e325856443da6067298d1c6ab31b95679839361f4a60adc5f7434944fb17"} [citrulline-p27648629] The Assessment of short-term effect of L-Citrulline on endothelial function via FMD to NMD ratio in known CAD patients: A randomized, cross-over clinical trial (Clinical trial number: NCT02638727). (2017). https://pubmed.ncbi.nlm.nih.gov/27648629/ DOI: 10.1515/rjim-2016-0045
Complete structured claim and evidence
The events it takes part in
A mechanism often involves more than two components. These are the full events, with every participant and its role.
Situations it appears in
Low-supply and faulty-machinery situations recorded in the chapters where this component plays a part.
In the sources
Preserved passages that mention this component, quoted exactly. Open one to read it in context.
Open hypotheses
Proposed ideas that involve this component. They are labeled as hypotheses and do not change any recorded statement.
This is a research prototype built from draft material. It is not medical advice, and its statements still await verification against the original studies.