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(2017). https://pubmed.ncbi.nlm.nih.gov/27648629/ DOI: 10.1515/rjim-2016-0045","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"tissue_or_cell_type","value_text":"Brachial FMD/NMD ratio","comparator":null,"unit":null,"notes":"","entity":null}],"evidence":[{"id":"f6ba3807-ad18-5b49-903e-07ee43e827f4","evidence_kind":"source_excerpt","locator":"Lines 1230-1241","start_line":1230,"end_line":1241,"excerpt":"### citrulline-cad-ratio\nThe FMD/NMD ratio increased by 0.12 with citrulline versus 0.01 with placebo in the CAD trial.\nCondition category: normal\nnutrient_topic: Citrulline research collection; topical membership is not evidence of a direct dietary effect.\nplain_language: A vascular-response ratio improved in this selected patient group.\norganism: Human, 30 coronary-artery-disease patients\ntissue_or_cell_type: Brachial FMD/NMD ratio\nexperimental_model: Randomized placebo crossover vascular trial\nlimitations: Small surrogate trial; abstract reports unusual FMD units, so only the dimensionless ratio is extracted.\nexposure: Fifteen-day L-citrulline and placebo periods\nevidence_span: {\"source_cache\": \"artifacts/citrulline-research/27648629.abstract.txt\", \"locator\": \"Primary indexed abstract; zero-based, end-exclusive Unicode character offsets\", \"file_sha256\": \"7584e325856443da6067298d1c6ab31b95679839361f4a60adc5f7434944fb17\", \"start_char\": 0, \"end_char\": 1848, \"text_sha256\": \"7584e325856443da6067298d1c6ab31b95679839361f4a60adc5f7434944fb17\"}\n[citrulline-p27648629] The Assessment of short-term effect of L-Citrulline on endothelial function via FMD to NMD ratio in known CAD patients: A randomized, cross-over clinical trial (Clinical trial number: NCT02638727). 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