Boron complex with cyclic ADP-ribose: molecular mechanisms & dependencies

How nutrients influence it

Every nutrient with a recorded effect on this component, credited to the nutrient that acted rather than the chapter that recorded it. Open a nutrient to see the findings and the conditions they were measured under.

Human evidence only

How nutrients reach it in more than one step

Chains of two or more recorded steps that end here, grouped by the nutrient they start from. Each step is a separate finding, so a chain is a route a mechanism could take, not proof that it does.

Tracing routes…

What it does

Every recorded relationship this component is part of, grouped by its role. Plain wording comes first; the technical statement follows.

Recorded relationships

What acts on it

Boric acid bound cyclic ADP-ribose with an apparent association constant of 655 ± 99 L/mol in the electrospray assay at pH 10.3.
Cyclic ADP-ribose → Boron complex with cyclic ADP-ribose source_derived_draftungraded
Experimental context and source evidence
evidence_span
{"source_cache": "artifacts/boron-research/16545389.abstract.txt", "locator": "Exact primary indexed abstract; zero-based, end-exclusive Unicode character offsets", "file_sha256": "720b1c99bd2628157e48db8085947552afc30029faeb65fb9235541b95c4b655", "start_char": 0, "end_char": 724, "text_sha256": "720b1c99bd2628157e48db8085947552afc30029faeb65fb9235541b95c4b655"}
experimental_model
Purified Aplysia cyclase kinetics and electrospray complex analysis
exposure
Noncompetitive inhibition Ki 40.5 ± 0.5 mM boric acid; cADPR-binding assay pH 10.3
limitations
The enzyme was Aplysia cyclase, not human CD38. Millimolar enzyme inhibition and alkaline binding data do not establish effects of ordinary dietary boron.
nutrient_topic
Boron research collection; topical membership is not evidence of a direct dietary effect. · Boron
organism
Aplysia enzyme; cell-free chemistry
plain_language
Boron can complex the calcium messenger cADPR under the tested chemical conditions.
primary_references
[boron-p16545389] Boric acid inhibits adenosine diphosphate-ribosyl cyclase non-competitively. (2006). https://pubmed.ncbi.nlm.nih.gov/16545389/ DOI: 10.1016/j.chroma.2006.02.066
tissue_or_cell_type
Purified enzyme and metabolites
Boron: chemistry, nutrient interactions, low-intake studies and mechanistic uncertainties (2026-09-17) · lines 170–181
AI-assisted literature curation; primary study URLs and scope retained in the document and extraction. Not publisher full text. · supports · Purified Aplysia cyclase kinetics and electrospray complex analysis · source_derived_draft · unverified_draft
### boron-cadpr-binding Boric acid bound cyclic ADP-ribose with an apparent association constant of 655 ± 99 L/mol in the electrospray assay at pH 10.3. Condition category: normal nutrient_topic: Boron research collection; topical membership is not evidence of a direct dietary effect. plain_language: Boron can complex the calcium messenger cADPR under the tested chemical conditions. organism: Aplysia enzyme; cell-free chemistry tissue_or_cell_type: Purified enzyme and metabolites experimental_model: Purified Aplysia cyclase kinetics and electrospray complex analysis limitations: The enzyme was Aplysia cyclase, not human CD38. Millimolar enzyme inhibition and alkaline binding data do not establish effects of ordinary dietary boron. exposure: Noncompetitive inhibition Ki 40.5 ± 0.5 mM boric acid; cADPR-binding assay pH 10.3 evidence_span: {"source_cache": "artifacts/boron-research/16545389.abstract.txt", "locator": "Exact primary indexed abstract; zero-based, end-exclusive Unicode character offsets", "file_sha256": "720b1c99bd2628157e48db8085947552afc30029faeb65fb9235541b95c4b655", "start_char": 0, "end_char": 724, "text_sha256": "720b1c99bd2628157e48db8085947552afc30029faeb65fb9235541b95c4b655"} [boron-p16545389] Boric acid inhibits adenosine diphosphate-ribosyl cyclase non-competitively. (2006). https://pubmed.ncbi.nlm.nih.gov/16545389/ DOI: 10.1016/j.chroma.2006.02.066
Complete structured claim and evidence
Mass spectrometry detected boric-acid adducts of cyclic ADP-ribose in the study of DU-145 calcium signaling.
Cyclic ADP-ribose → Boron complex with cyclic ADP-ribose source_derived_draftungraded
Experimental context and source evidence
evidence_span
{"source_cache": "artifacts/boron-research/18516691.abstract.txt", "locator": "Exact primary indexed abstract; zero-based, end-exclusive Unicode character offsets", "file_sha256": "5fc4f02e11634c2a2d111a99ee4c6175fe8839a8f28152b656b3c29be6745206", "start_char": 0, "end_char": 1733, "text_sha256": "5fc4f02e11634c2a2d111a99ee4c6175fe8839a8f28152b656b3c29be6745206"}
experimental_model
Human prostate cancer cell culture and mass spectrometry
exposure
Boric acid 100–1,000 µM; methylboronic acid comparator
limitations
These are cell-culture exposures, including concentrations far above usual circulating levels. Adduct detection and calcium responses do not prove cancer prevention or direct channel binding.
nutrient_topic
Boron research collection; topical membership is not evidence of a direct dietary effect. · Boron
organism
Human DU-145 cells; cell-free complex analysis
plain_language
The study found a chemical interaction with cADPR, while its cellular role still requires separate evidence.
primary_references
[boron-p18516691] Boric acid inhibits stored Ca2+ release in DU-145 prostate cancer cells. (2009). https://pubmed.ncbi.nlm.nih.gov/18516691/ DOI: 10.1007/s10565-008-9085-7
tissue_or_cell_type
Cell-free mass-spectrometry assay associated with the cell study
Boron: chemistry, nutrient interactions, low-intake studies and mechanistic uncertainties (2026-09-17) · lines 313–324
AI-assisted literature curation; primary study URLs and scope retained in the document and extraction. Not publisher full text. · supports · Human prostate cancer cell culture and mass spectrometry · source_derived_draft · unverified_draft
### boron-cadpr-complex-cell-study Mass spectrometry detected boric-acid adducts of cyclic ADP-ribose in the study of DU-145 calcium signaling. Condition category: normal nutrient_topic: Boron research collection; topical membership is not evidence of a direct dietary effect. plain_language: The study found a chemical interaction with cADPR, while its cellular role still requires separate evidence. organism: Human DU-145 cells; cell-free complex analysis tissue_or_cell_type: Cell-free mass-spectrometry assay associated with the cell study experimental_model: Human prostate cancer cell culture and mass spectrometry limitations: These are cell-culture exposures, including concentrations far above usual circulating levels. Adduct detection and calcium responses do not prove cancer prevention or direct channel binding. exposure: Boric acid 100–1,000 µM; methylboronic acid comparator evidence_span: {"source_cache": "artifacts/boron-research/18516691.abstract.txt", "locator": "Exact primary indexed abstract; zero-based, end-exclusive Unicode character offsets", "file_sha256": "5fc4f02e11634c2a2d111a99ee4c6175fe8839a8f28152b656b3c29be6745206", "start_char": 0, "end_char": 1733, "text_sha256": "5fc4f02e11634c2a2d111a99ee4c6175fe8839a8f28152b656b3c29be6745206"} [boron-p18516691] Boric acid inhibits stored Ca2+ release in DU-145 prostate cancer cells. (2009). https://pubmed.ncbi.nlm.nih.gov/18516691/ DOI: 10.1007/s10565-008-9085-7
Complete structured claim and evidence

The events it takes part in

A mechanism often involves more than two components. These are the full events, with every participant and its role.

Situations it appears in

Low-supply and faulty-machinery situations recorded in the chapters where this component plays a part.

In the sources

Preserved passages that mention this component, quoted exactly. Open one to read it in context.

Open hypotheses

Proposed ideas that involve this component. They are labeled as hypotheses and do not change any recorded statement.

This is a research prototype built from draft material. It is not medical advice, and its statements still await verification against the original studies.

Boron complex with cyclic ADP-ribose