Component
Bone microarchitecture
Bone microarchitecture. Species, exposure and limitations are retained in each linked claim.
1 recorded relationships. Experimental role, claim status and evidence remain attached to each record.
How nutrients influence it
Every nutrient with a recorded effect on this component, credited to the nutrient that acted rather than the chapter that recorded it. Open a nutrient to see the findings and the conditions they were measured under.
Other things that act on it
Enzymes, hormones, genes, and other components with a recorded effect. These are not nutrients, so they do not count toward the arrows above. Each finding names the chapter that recorded it.
How nutrients reach it in more than one step
Chains of two or more recorded steps that end here, grouped by the nutrient they start from. Each step is a separate finding, so a chain is a route a mechanism could take, not proof that it does.
Tracing routes…
What it does
Every recorded relationship this component is part of, grouped by its role. Plain wording comes first; the technical statement follows.
Where it participates (unsigned role)
After three years, BMD declined without significant between-group differences, and microarchitecture and turnover changes were also similar.
Experimental context and source evidence
- evidence_span
- {"source_cache": "artifacts/k2-research/33030563.abstract.txt", "locator": "Exact primary indexed abstract; zero-based, end-exclusive Unicode character offsets", "file_sha256": "008ef1b176a3f718d923eea696a7a97b09d64e3079e57c997beaf485153ca138", "start_char": 0, "end_char": 2370, "text_sha256": "008ef1b176a3f718d923eea696a7a97b09d64e3079e57c997beaf485153ca138"}
- experimental_model
- Three-year double-blind randomized add-on trial
- exposure
- MK-7 375 micrograms/day versus placebo; both groups D3 38 micrograms/day and calcium 800 mg/day
- limitations
- Different population, dose and background supplementation from the 180-microgram trial; the one-year and three-year reports are not independent cohorts.
- nutrient_topic
- Vitamin K2 research collection; topical membership is not evidence of a direct dietary effect. · Vitamin K2 / menaquinone family
- organism
- 142 postmenopausal women with osteopenia
- plain_language
- Improved carboxylation did not translate into a demonstrated bone-density benefit in this trial.
- primary_references
- [k2-p33030563] The effect of vitamin MK-7 on bone mineral density and microarchitecture in postmenopausal women with osteopenia, a 3-year randomized, placebo-controlled clinical trial. (2021). https://pubmed.ncbi.nlm.nih.gov/33030563/ DOI: 10.1007/s00198-020-05638-z
- tissue_or_cell_type
- Osteocalcin, DXA and bone microarchitecture
Vitamin K2: menaquinone forms, carboxylation, recycling and nutrient interactions (2026-09-17) · lines 1098–1109
AI-assisted literature curation; primary study URLs and scope retained in the document and extraction. Not publisher full text. · supports · Three-year double-blind randomized add-on trial · source_derived_draft · unverified_draft
### k2-mk7-cad-bone-null After three years, BMD declined without significant between-group differences, and microarchitecture and turnover changes were also similar. Condition category: normal nutrient_topic: Vitamin K2 research collection; topical membership is not evidence of a direct dietary effect. plain_language: Improved carboxylation did not translate into a demonstrated bone-density benefit in this trial. organism: 142 postmenopausal women with osteopenia tissue_or_cell_type: Osteocalcin, DXA and bone microarchitecture experimental_model: Three-year double-blind randomized add-on trial limitations: Different population, dose and background supplementation from the 180-microgram trial; the one-year and three-year reports are not independent cohorts. exposure: MK-7 375 micrograms/day versus placebo; both groups D3 38 micrograms/day and calcium 800 mg/day evidence_span: {"source_cache": "artifacts/k2-research/33030563.abstract.txt", "locator": "Exact primary indexed abstract; zero-based, end-exclusive Unicode character offsets", "file_sha256": "008ef1b176a3f718d923eea696a7a97b09d64e3079e57c997beaf485153ca138", "start_char": 0, "end_char": 2370, "text_sha256": "008ef1b176a3f718d923eea696a7a97b09d64e3079e57c997beaf485153ca138"} [k2-p33030563] The effect of vitamin MK-7 on bone mineral density and microarchitecture in postmenopausal women with osteopenia, a 3-year randomized, placebo-controlled clinical trial. (2021). https://pubmed.ncbi.nlm.nih.gov/33030563/ DOI: 10.1007/s00198-020-05638-z
Complete structured claim and evidence
The events it takes part in
A mechanism often involves more than two components. These are the full events, with every participant and its role.
Situations it appears in
Low-supply and faulty-machinery situations recorded in the chapters where this component plays a part.
In the sources
Preserved passages that mention this component, quoted exactly. Open one to read it in context.
Open hypotheses
Proposed ideas that involve this component. They are labeled as hypotheses and do not change any recorded statement.
This is a research prototype built from draft material. It is not medical advice, and its statements still await verification against the original studies.