Component
BMS-204493
Pan-RAR antagonist/inverse agonist used in embryonic gonad cultures; receptor-corepressor stabilization differs from receptor deletion.
1 recorded relationships. Experimental role, claim status and evidence remain attached to each record.
How nutrients influence it
Every nutrient with a recorded effect on this component, credited to the nutrient that acted rather than the chapter that recorded it. Open a nutrient to see the findings and the conditions they were measured under.
Other things that act on it
Enzymes, hormones, genes, and other components with a recorded effect. These are not nutrients, so they do not count toward the arrows above. Each finding names the chapter that recorded it.
How nutrients reach it in more than one step
Chains of two or more recorded steps that end here, grouped by the nutrient they start from. Each step is a separate finding, so a chain is a route a mechanism could take, not proof that it does.
Tracing routes…
What it does
Every recorded relationship this component is part of, grouped by its role. Plain wording comes first; the technical statement follows.
Where it participates (unsigned role)
The 2006 study inferred that RAR signaling is required for fetal ovarian Stra8 induction after BMS-204493 suppressed its expression.
Experimental context and source evidence
- cross_nutrient
- false
- experimental_model
- Pharmacologic model inference
- exposure
- E11.5 ovaries; 5 micromolar BMS-204493 for 2 days.
- limitations
- Disputed necessity inference; receptor repression differs from receptor deletion.
- nutrient_topic
- Vitamin A expansion research collection; topical membership is not evidence of a direct dietary effect. · Vitamin A
- organism
- Mus musculus
- plain_language
- An early drug experiment supported a requirement later challenged by genetics.
- primary_references
- [koubova2006] Retinoic acid regulates sex-specific timing of meiotic initiation in mice. (2006). https://pubmed.ncbi.nlm.nih.gov/16461896/ DOI: 10.1073/pnas.0510813103
- tissue_or_cell_type
- fetal ovary
Vitamin A expansion: reproduction, light-driven vision and shared mechanisms (2026-09-17) · lines 187–198
AI-assisted literature curation; primary study URLs and scope retained in the document and extraction. Not publisher full text. · supports · Pharmacologic model inference · source_derived_draft · unverified_draft
### va-repro-rar-necessity-model The 2006 study inferred that RAR signaling is required for fetal ovarian Stra8 induction after BMS-204493 suppressed its expression. Condition category: normal nutrient_topic: Vitamin A expansion research collection; topical membership is not evidence of a direct dietary effect. plain_language: An early drug experiment supported a requirement later challenged by genetics. organism: Mus musculus tissue_or_cell_type: fetal ovary experimental_model: Pharmacologic model inference limitations: Disputed necessity inference; receptor repression differs from receptor deletion. exposure: E11.5 ovaries; 5 micromolar BMS-204493 for 2 days. cross_nutrient: false [koubova2006] Retinoic acid regulates sex-specific timing of meiotic initiation in mice. (2006). https://pubmed.ncbi.nlm.nih.gov/16461896/ DOI: 10.1073/pnas.0510813103
Complete structured claim and evidence
The events it takes part in
A mechanism often involves more than two components. These are the full events, with every participant and its role.
Situations it appears in
Low-supply and faulty-machinery situations recorded in the chapters where this component plays a part.
In the sources
Preserved passages that mention this component, quoted exactly. Open one to read it in context.
Open hypotheses
Proposed ideas that involve this component. They are labeled as hypotheses and do not change any recorded statement.
This is a research prototype built from draft material. It is not medical advice, and its statements still await verification against the original studies.