Component
Bone morphogenetic protein 6
Independent biological entity. Read linked claims for experimental scope and context.
2 recorded relationships. Experimental role, claim status and evidence remain attached to each record.
How nutrients influence it
Every nutrient with a recorded effect on this component, credited to the nutrient that acted rather than the chapter that recorded it. Open a nutrient to see the findings and the conditions they were measured under.
Other things that act on it
Enzymes, hormones, genes, and other components with a recorded effect. These are not nutrients, so they do not count toward the arrows above. Each finding names the chapter that recorded it.
How nutrients reach it in more than one step
Chains of two or more recorded steps that end here, grouped by the nutrient they start from. Each step is a separate finding, so a chain is a route a mechanism could take, not proof that it does.
Tracing routes…
What it does
Every recorded relationship this component is part of, grouped by its role. Plain wording comes first; the technical statement follows.
What it acts on
The study demonstrated a physical interaction between BMP6 and soluble hemojuvelin fusion protein.
Experimental context and source evidence
- evidence_span
- {"source_cache": "artifacts/iron-research/19252486.abstract.txt", "locator": "Exact primary indexed abstract; zero-based, end-exclusive Unicode character offsets", "file_sha256": "f51b7e3f2c0882e3da19cc1f55c13f742c4cd47ca3db21bcc40be6263af76f2b", "start_char": 0, "end_char": 1168, "text_sha256": "f51b7e3f2c0882e3da19cc1f55c13f742c4cd47ca3db21bcc40be6263af76f2b"}
- experimental_model
- Ligand binding, antibody treatment and knockout studies
- exposure
- BMP6, BMP6 antibody, soluble HJV and Bmp6 deletion
- limitations
- Mouse causal regulation; the role of other BMP ligands is not excluded.
- nutrient_topic
- Iron research collection; topical membership is not evidence of a direct dietary effect. · Iron
- organism
- Mice and biochemical HJV/BMP systems
- plain_language
- A ligand and its coreceptor form part of the signal controlling iron release.
- primary_references
- [iron-p19252486] BMP6 is a key endogenous regulator of hepcidin expression and iron metabolism. (2009). https://pubmed.ncbi.nlm.nih.gov/19252486/ DOI: 10.1038/ng.335
- tissue_or_cell_type
- Liver, blood and tissues
Iron: absorption, trafficking, iron-dependent enzymes and nutrient interactions (2026-09-17) · lines 771–782
AI-assisted literature curation; primary study URLs and scope retained in the document and extraction. Not publisher full text. · supports · Ligand binding, antibody treatment and knockout studies · source_derived_draft · unverified_draft
### iron-bmp6-hemojuvelin The study demonstrated a physical interaction between BMP6 and soluble hemojuvelin fusion protein. Condition category: normal nutrient_topic: Iron research collection; topical membership is not evidence of a direct dietary effect. plain_language: A ligand and its coreceptor form part of the signal controlling iron release. organism: Mice and biochemical HJV/BMP systems tissue_or_cell_type: Liver, blood and tissues experimental_model: Ligand binding, antibody treatment and knockout studies limitations: Mouse causal regulation; the role of other BMP ligands is not excluded. exposure: BMP6, BMP6 antibody, soluble HJV and Bmp6 deletion evidence_span: {"source_cache": "artifacts/iron-research/19252486.abstract.txt", "locator": "Exact primary indexed abstract; zero-based, end-exclusive Unicode character offsets", "file_sha256": "f51b7e3f2c0882e3da19cc1f55c13f742c4cd47ca3db21bcc40be6263af76f2b", "start_char": 0, "end_char": 1168, "text_sha256": "f51b7e3f2c0882e3da19cc1f55c13f742c4cd47ca3db21bcc40be6263af76f2b"} [iron-p19252486] BMP6 is a key endogenous regulator of hepcidin expression and iron metabolism. (2009). https://pubmed.ncbi.nlm.nih.gov/19252486/ DOI: 10.1038/ng.335
Complete structured claim and evidence
Where it participates (unsigned role)
Vitamin A-deficient rats showed lower hepatic Hamp transcripts despite increased Bmp6 and Hfe2 transcripts.
Experimental context and source evidence
- availability_state
- nutrient_deficiency Imported condition classification; unverified.
- cross_nutrient
- Vitamin A/iron -> hepcidin regulation.
- experimental_model
- Dietary comparison; hepatic mRNA.
- limitations
- Not a direct demonstration of BMP signaling flux or circulating hepcidin.
- nutrient_topic
- Vitamin A research collection; topical membership is not evidence of a direct dietary effect. · Vitamin A
- organism
- Rattus norvegicus
- plain_language
- The measured regulatory signals did not all move in the same direction.
- primary_references
- [va-cunha2016] Vitamin A deficiency modulates iron metabolism independent of hemojuvelin (Hfe2) and bone morphogenetic protein 6 (Bmp6) transcript levels (2016). https://pubmed.ncbi.nlm.nih.gov/27551308/ DOI: 10.1186/s12263-016-0519-4
- tissue_or_cell_type
- Liver
- trigger_kind
- nutrient_deficiency Imported condition classification; unverified.
Vitamin A: forms, mechanisms, deficiency and excess (2026-09-17) · lines 1766–1776
AI-assisted literature curation; primary study URLs and scope retained in the document and extraction. Not publisher full text. · supports · Dietary comparison; hepatic mRNA. · source_derived_draft · unverified_draft
### va-deficiency-hepcidin-transcript Vitamin A-deficient rats showed lower hepatic Hamp transcripts despite increased Bmp6 and Hfe2 transcripts. Condition category: nutrient_deficiency nutrient_topic: Vitamin A research collection; topical membership is not evidence of a direct dietary effect. plain_language: The measured regulatory signals did not all move in the same direction. organism: Rattus norvegicus tissue_or_cell_type: Liver experimental_model: Dietary comparison; hepatic mRNA. limitations: Not a direct demonstration of BMP signaling flux or circulating hepcidin. cross_nutrient: Vitamin A/iron -> hepcidin regulation. [va-cunha2016] Vitamin A deficiency modulates iron metabolism independent of hemojuvelin (Hfe2) and bone morphogenetic protein 6 (Bmp6) transcript levels (2016). https://pubmed.ncbi.nlm.nih.gov/27551308/ DOI: 10.1186/s12263-016-0519-4
Complete structured claim and evidence
The events it takes part in
A mechanism often involves more than two components. These are the full events, with every participant and its role.
Situations it appears in
Low-supply and faulty-machinery situations recorded in the chapters where this component plays a part.
In the sources
Preserved passages that mention this component, quoted exactly. Open one to read it in context.
Open hypotheses
Proposed ideas that involve this component. They are labeled as hypotheses and do not change any recorded statement.
This is a research prototype built from draft material. It is not medical advice, and its statements still await verification against the original studies.