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(2009). https://pubmed.ncbi.nlm.nih.gov/19252486/ DOI: 10.1038/ng.335","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"tissue_or_cell_type","value_text":"Liver, blood and tissues","comparator":null,"unit":null,"notes":"","entity":null}],"evidence":[{"id":"d5b83192-c8c5-51e0-aa34-7e2c07937030","evidence_kind":"source_excerpt","locator":"Lines 771-782","start_line":771,"end_line":782,"excerpt":"### iron-bmp6-hemojuvelin\nThe study demonstrated a physical interaction between BMP6 and soluble hemojuvelin fusion protein.\nCondition category: normal\nnutrient_topic: Iron research collection; topical membership is not evidence of a direct dietary effect.\nplain_language: A ligand and its coreceptor form part of the signal controlling iron release.\norganism: Mice and biochemical HJV/BMP systems\ntissue_or_cell_type: Liver, blood and tissues\nexperimental_model: Ligand binding, antibody treatment and knockout studies\nlimitations: Mouse causal regulation; the role of other BMP ligands is not excluded.\nexposure: BMP6, BMP6 antibody, soluble HJV and Bmp6 deletion\nevidence_span: {\"source_cache\": \"artifacts/iron-research/19252486.abstract.txt\", \"locator\": \"Exact primary indexed abstract; zero-based, end-exclusive Unicode character offsets\", \"file_sha256\": \"f51b7e3f2c0882e3da19cc1f55c13f742c4cd47ca3db21bcc40be6263af76f2b\", \"start_char\": 0, \"end_char\": 1168, \"text_sha256\": \"f51b7e3f2c0882e3da19cc1f55c13f742c4cd47ca3db21bcc40be6263af76f2b\"}\n[iron-p19252486] BMP6 is a key endogenous regulator of hepcidin expression and iron metabolism. 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