Component
Blood total cholesterol concentration
2 recorded relationships. Experimental role, claim status and evidence remain attached to each record.
How nutrients influence it
Every nutrient with a recorded effect on this component, credited to the nutrient that acted rather than the chapter that recorded it. Open a nutrient to see the findings and the conditions they were measured under.
Other things that act on it
Enzymes, hormones, genes, and other components with a recorded effect. These are not nutrients, so they do not count toward the arrows above. Each finding names the chapter that recorded it.
How nutrients reach it in more than one step
Chains of two or more recorded steps that end here, grouped by the nutrient they start from. Each step is a separate finding, so a chain is a route a mechanism could take, not proof that it does.
Tracing routes…
What it does
Every recorded relationship this component is part of, grouped by its role. Plain wording comes first; the technical statement follows.
What acts on it
At relatively low total dosage the pooled mean difference in total cholesterol was +5.27 against control, and it remained +3.18 at relatively high dosage.
Experimental context and source evidence
- duration
- Trial durations differ
- evidence_access
- Primary PubMed abstract and indexed metadata reviewed. Full-text method details not stated here remain unresolved.
- experimental_model
- Human, meta-analysis of randomized controlled trials
- exposure
- Nattokinase supplementation
- limitations
- The direction is unfavourable, which is the opposite of what the uncontrolled cohort studies in this chapter report. Units are as given in the source and the analysis pools heterogeneous assays.
- organism
- Human, meta-analysis of randomized controlled trials
- plain_language
- At relatively low total dosage the pooled mean difference in total cholesterol was +5.27 against control, and it remained +3.18 at relatively high dosage.
- primary_references
- Nattokinase Supplementation and Cardiovascular Risk Factors: A Systematic Review and Meta-Analysis of Randomized Controlled Trials. (2023) https://pubmed.ncbi.nlm.nih.gov/39076715/ DOI: 10.31083/j.rcm2408234
- route
- In vivo, oral
- tissue
- Blood lipids
Nattokinase: what the purified enzyme cleaves, what survives being eaten, and the gap between the two (2026-09-23) · lines 1060–1060
Original AI-assisted curation built from a supplied entity-first document of 105 entities and 129 claims. Every reference in that document was resolved against live PubMed with its abstract read and its DOI cross-checked on 2026-09-23, and the EFSA novel-food opinion was retrieved and read in full. That check corrected two PMIDs that pointed at unrelated papers, two DOIs, and two papers recorded as carrying no erratum that do carry one; it also reversed three findings the supplied document had stated backwards. Two papers carry a published correction, recorded as such and not as a retraction. Three sources are not indexed in PubMed and are cited by what they have. Laboratory lineages are recorded, so the four papers from one group, the three from another and the two readings of a single applicant dossier cannot be counted as separate lines of support. Study-specific doses, units, populations and limitations retained; activity units are never converted between systems. Not publisher full text. · supports · Human, meta-analysis of randomized controlled trials · source_derived_draft · unverified_draft
At relatively low total dosage the pooled mean difference in total cholesterol was +5.27 against control, and it remained +3.18 at relatively high dosage.
Complete structured claim and evidenceBlood lipids were unaffected over the same two months.
Experimental context and source evidence
- duration
- 2 months
- evidence_access
- Primary PubMed abstract and indexed metadata reviewed. Full-text method details not stated here remain unresolved.
- experimental_model
- Human (45 subjects across three groups)
- exposure
- Nattokinase, 4,000 FU per day
- limitations
- A measured null in an uncontrolled study, recorded because the lipid question is contested elsewhere in this chapter.
- organism
- Human (45 subjects across three groups)
- plain_language
- Blood lipids were unaffected over the same two months.
- primary_references
- Nattokinase decreases plasma levels of fibrinogen, factor VII, and factor VIII in human subjects. (2009) https://pubmed.ncbi.nlm.nih.gov/19358933/ DOI: 10.1016/j.nutres.2009.01.009
- route
- In vivo, oral
- tissue
- Plasma
Nattokinase: what the purified enzyme cleaves, what survives being eaten, and the gap between the two (2026-09-23) · lines 950–950
Original AI-assisted curation built from a supplied entity-first document of 105 entities and 129 claims. Every reference in that document was resolved against live PubMed with its abstract read and its DOI cross-checked on 2026-09-23, and the EFSA novel-food opinion was retrieved and read in full. That check corrected two PMIDs that pointed at unrelated papers, two DOIs, and two papers recorded as carrying no erratum that do carry one; it also reversed three findings the supplied document had stated backwards. Two papers carry a published correction, recorded as such and not as a retraction. Three sources are not indexed in PubMed and are cited by what they have. Laboratory lineages are recorded, so the four papers from one group, the three from another and the two readings of a single applicant dossier cannot be counted as separate lines of support. Study-specific doses, units, populations and limitations retained; activity units are never converted between systems. Not publisher full text. · supports · Human (45 subjects across three groups) · source_derived_draft · unverified_draft
Blood lipids were unaffected over the same two months.
Complete structured claim and evidence
The events it takes part in
A mechanism often involves more than two components. These are the full events, with every participant and its role.
Situations it appears in
Low-supply and faulty-machinery situations recorded in the chapters where this component plays a part.
In the sources
Preserved passages that mention this component, quoted exactly. Open one to read it in context.
Open hypotheses
Proposed ideas that involve this component. They are labeled as hypotheses and do not change any recorded statement.
This is a research prototype built from draft material. It is not medical advice, and its statements still await verification against the original studies.