Component
Binge drinking
Binge drinking. Species, exposure and limitations are retained in each linked claim.
1 recorded relationships. Experimental role, claim status and evidence remain attached to each record.
How nutrients influence it
Every nutrient with a recorded effect on this component, credited to the nutrient that acted rather than the chapter that recorded it. Open a nutrient to see the findings and the conditions they were measured under.
Other things that act on it
Enzymes, hormones, genes, and other components with a recorded effect. These are not nutrients, so they do not count toward the arrows above. Each finding names the chapter that recorded it.
How nutrients reach it in more than one step
Chains of two or more recorded steps that end here, grouped by the nutrient they start from. Each step is a separate finding, so a chain is a route a mechanism could take, not proof that it does.
Tracing routes…
What it does
Every recorded relationship this component is part of, grouped by its role. Plain wording comes first; the technical statement follows.
Where it participates (unsigned role)
Carriers of the ADH1B rs1229984 A-allele consumed 17.2% fewer units per week, had lower systolic blood pressure, interleukin-6, waist circumference and body mass index, and had lower odds of coronary heart disease (odds ratio 0.90), with the protective association the same across all categories of alcohol consumption.
Experimental context and source evidence
- evidence_span
- {"source_cache": "artifacts/alcohol-research/25011450.abstract.txt", "locator": "Indexed abstract; zero-based, end-exclusive Unicode character offsets", "file_sha256": "d8f5f9f8c57fc5e32e827d8db1f212ebb427553d9b9f59db611a622bd99c4a10", "start_char": 0, "end_char": 1978, "text_sha256": "d8f5f9f8c57fc5e32e827d8db1f212ebb427553d9b9f59db611a622bd99c4a10"}
- experimental_model
- Mendelian randomisation meta-analysis of 56 studies and 261,991 individuals
- exposure
- The ADH1B rs1229984 variant as an instrument for alcohol exposure
- limitations
- Genetic instrument design, which avoids the confounding and reverse causation of consumption questionnaires. It cannot speak to drinking patterns the variant does not affect.
- nutrient_topic
- Alcohol research collection; topical membership is not evidence of a direct clinical effect, and ethanol is recorded separately from the acetaldehyde it becomes. · Ethanol
- organism
- Human
- plain_language
- The gene variant that makes people drink less also gives them less heart disease, including among light drinkers.
- primary_references
- [alcohol-p25011450] Association between alcohol and cardiovascular disease: Mendelian randomisation analysis based on individual participant data. (2014). https://pubmed.ncbi.nlm.nih.gov/25011450/ DOI: 10.1136/bmj.g4164
- tissue_or_cell_type
- Cardiovascular system
Alcohol: ethanol clearance, acetaldehyde, the channels it binds, organ injury and nutrient collisions (2026-09-21) · lines 566–577
AI-assisted literature curation; primary study URLs and scope retained in the document and extraction. Not publisher full text. · supports · Mendelian randomisation meta-analysis of 56 studies and 261,991 individuals · source_derived_draft · unverified_draft
### alcohol-mendelian-cardiovascular Carriers of the ADH1B rs1229984 A-allele consumed 17.2% fewer units per week, had lower systolic blood pressure, interleukin-6, waist circumference and body mass index, and had lower odds of coronary heart disease (odds ratio 0.90), with the protective association the same across all categories of alcohol consumption. Condition category: normal nutrient_topic: Alcohol research collection; topical membership is not evidence of a direct clinical effect, and ethanol is recorded separately from the acetaldehyde it becomes. plain_language: The gene variant that makes people drink less also gives them less heart disease, including among light drinkers. organism: Human tissue_or_cell_type: Cardiovascular system experimental_model: Mendelian randomisation meta-analysis of 56 studies and 261,991 individuals limitations: Genetic instrument design, which avoids the confounding and reverse causation of consumption questionnaires. It cannot speak to drinking patterns the variant does not affect. exposure: The ADH1B rs1229984 variant as an instrument for alcohol exposure evidence_span: {"source_cache": "artifacts/alcohol-research/25011450.abstract.txt", "locator": "Indexed abstract; zero-based, end-exclusive Unicode character offsets", "file_sha256": "d8f5f9f8c57fc5e32e827d8db1f212ebb427553d9b9f59db611a622bd99c4a10", "start_char": 0, "end_char": 1978, "text_sha256": "d8f5f9f8c57fc5e32e827d8db1f212ebb427553d9b9f59db611a622bd99c4a10"} [alcohol-p25011450] Association between alcohol and cardiovascular disease: Mendelian randomisation analysis based on individual participant data. (2014). https://pubmed.ncbi.nlm.nih.gov/25011450/ DOI: 10.1136/bmj.g4164
Complete structured claim and evidence
The events it takes part in
A mechanism often involves more than two components. These are the full events, with every participant and its role.
Situations it appears in
Low-supply and faulty-machinery situations recorded in the chapters where this component plays a part.
In the sources
Preserved passages that mention this component, quoted exactly. Open one to read it in context.
Open hypotheses
Proposed ideas that involve this component. They are labeled as hypotheses and do not change any recorded statement.
This is a research prototype built from draft material. It is not medical advice, and its statements still await verification against the original studies.