{"id":"89a590dc-1957-5ffc-9018-e48ad2a65bb2","stable_key":"fcc4fa9c-4dc8-5566-b780-1a486c4d3e72:alcohol-mendelian-cardiovascular","predicate":"reduces","statement":"Carriers of the ADH1B rs1229984 A-allele consumed 17.2% fewer units per week, had lower systolic blood pressure, interleukin-6, waist circumference and body mass index, and had lower odds of coronary heart disease (odds ratio 0.90), with the protective association the same across all categories of alcohol consumption.","claim_class":"observational","status":"source_derived_draft","evidence_grade":"ungraded","direction":"negative","is_public":true,"mechanism_event_id":"6749e798-e103-5967-8bfe-d93e6051ca63","mechanism_event_label":"The gene variant that makes people drink less also gives them less heart disease, including among light drinkers.","subject":{"id":"25e632d9-6e0a-509d-8c0e-b7f8a389fd7d","slug":"adh1b-rs1229984","display_name":"The ADH1B rs1229984 A-allele (ADH1B*2, Arg48His)","entity_type_key":"gene"},"object":{"id":"85090025-4e92-5d9a-8557-80f398f8411e","slug":"coronary-heart-disease","display_name":"Coronary heart disease","entity_type_key":"cellular_process"},"evidence_count":1,"mechanism_event":{"id":"6749e798-e103-5967-8bfe-d93e6051ca63","stable_key":"fcc4fa9c-4dc8-5566-b780-1a486c4d3e72:alcohol-mendelian-cardiovascular-event","event_type":"observed_intervention","label":"The gene variant that makes people drink less also gives them less heart disease, including among light drinkers.","description":"Carriers of the ADH1B rs1229984 A-allele consumed 17.2% fewer units per week, had lower systolic blood pressure, interleukin-6, waist circumference and body mass index, and had lower odds of coronary heart disease (odds ratio 0.90), with the protective association the same across all categories of alcohol consumption.","status":"provisional","compartment":null,"participants":[{"entity":{"id":"38692dc7-dbe9-5295-bcb7-145c768b28a3","slug":"alcohol-consumption","display_name":"Habitual alcohol consumption","entity_type_key":"cellular_process"},"role":"reduced_exposure","stoichiometry":null,"state_label":"","sequence_order":0,"notes":""},{"entity":{"id":"8fc0ee41-c9a7-52d4-aebe-418a5307d96d","slug":"systolic-blood-pressure","display_name":"Systolic blood pressure","entity_type_key":"cellular_process"},"role":"co_measure","stoichiometry":null,"state_label":"","sequence_order":1,"notes":""},{"entity":{"id":"ef8f8807-395d-5dc6-9693-70e90f41b268","slug":"il6","display_name":"IL6","entity_type_key":"cytokine"},"role":"co_measure","stoichiometry":null,"state_label":"","sequence_order":2,"notes":""},{"entity":{"id":"c31b4dab-cf3b-5204-96f9-a8f6fe8af2bb","slug":"binge-drinking","display_name":"Binge drinking","entity_type_key":"cellular_process"},"role":"reduced_behaviour","stoichiometry":null,"state_label":"","sequence_order":3,"notes":""},{"entity":{"id":"25e632d9-6e0a-509d-8c0e-b7f8a389fd7d","slug":"adh1b-rs1229984","display_name":"The ADH1B rs1229984 A-allele (ADH1B*2, Arg48His)","entity_type_key":"gene"},"role":"subject","stoichiometry":null,"state_label":"","sequence_order":4,"notes":""},{"entity":{"id":"85090025-4e92-5d9a-8557-80f398f8411e","slug":"coronary-heart-disease","display_name":"Coronary heart disease","entity_type_key":"cellular_process"},"role":"target","stoichiometry":null,"state_label":"","sequence_order":5,"notes":""}]},"contexts":[{"dimension":"evidence_span","value_text":"{\"source_cache\": \"artifacts/alcohol-research/25011450.abstract.txt\", \"locator\": \"Indexed abstract; zero-based, end-exclusive Unicode character offsets\", \"file_sha256\": \"d8f5f9f8c57fc5e32e827d8db1f212ebb427553d9b9f59db611a622bd99c4a10\", \"start_char\": 0, \"end_char\": 1978, \"text_sha256\": \"d8f5f9f8c57fc5e32e827d8db1f212ebb427553d9b9f59db611a622bd99c4a10\"}","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"experimental_model","value_text":"Mendelian randomisation meta-analysis of 56 studies and 261,991 individuals","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"exposure","value_text":"The ADH1B rs1229984 variant as an instrument for alcohol exposure","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"limitations","value_text":"Genetic instrument design, which avoids the confounding and reverse causation of consumption questionnaires. 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