Component
Astroglial glutamine uptake
Astroglial glutamine uptake. Species, exposure and limitations are retained in each linked claim.
1 recorded relationships. Experimental role, claim status and evidence remain attached to each record.
How nutrients influence it
Every nutrient with a recorded effect on this component, credited to the nutrient that acted rather than the chapter that recorded it. Open a nutrient to see the findings and the conditions they were measured under.
Other things that act on it
Enzymes, hormones, genes, and other components with a recorded effect. These are not nutrients, so they do not count toward the arrows above. Each finding names the chapter that recorded it.
How nutrients reach it in more than one step
Chains of two or more recorded steps that end here, grouped by the nutrient they start from. Each step is a separate finding, so a chain is a route a mechanism could take, not proof that it does.
Tracing routes…
What it does
Every recorded relationship this component is part of, grouped by its role. Plain wording comes first; the technical statement follows.
What acts on it
Theanine inhibited glutamine accumulation in cultured rat astroglia.
Experimental context and source evidence
- evidence_span
- {"source_cache": "artifacts/theanine-research/18293419.abstract.txt", "locator": "Primary indexed abstract; zero-based, end-exclusive Unicode character offsets", "file_sha256": "c94471071feadec8a04eafa7e9d53999dd9756b7f1d5dc1f351152b9b5f4b5d3", "start_char": 0, "end_char": 1751, "text_sha256": "c94471071feadec8a04eafa7e9d53999dd9756b7f1d5dc1f351152b9b5f4b5d3"}
- experimental_model
- Radiotracer uptake in synaptosomes and cultured neural cells
- exposure
- Theanine 0.1-10 millimolar in uptake assays; sustained 10 millimolar for glutamate release
- limitations
- High cell concentrations; 10 mM is far above the approximately 25 micromolar plasma peak in the separate human 100 mg study. Different cells from the system L screen; no claim all routes are sodium-dependent.
- nutrient_topic
- L-Theanine research collection; topical membership is not evidence of a direct dietary effect. · L-Theanine
- organism
- Rat neurons and astroglia
- plain_language
- Competition for a precursor can alter a neurotransmitter-related metabolic pool.
- primary_references
- [theanine-p18293419] Theanine, an ingredient of green tea, inhibits [3H]glutamine transport in neurons and astroglia in rat brain. (2008). https://pubmed.ncbi.nlm.nih.gov/18293419/ DOI: 10.1002/jnr.21637
- tissue_or_cell_type
- Glutamine transport and extracellular glutamate
L-Theanine: metabolism, neural signaling, nutrient connections and human outcomes (2026-09-17) · lines 237–248
AI-assisted literature curation; primary study URLs and scope retained in the document and extraction. Not publisher full text. · supports · Radiotracer uptake in synaptosomes and cultured neural cells · source_derived_draft · unverified_draft
### theanine-gln-astroglia Theanine inhibited glutamine accumulation in cultured rat astroglia. Condition category: normal nutrient_topic: L-Theanine research collection; topical membership is not evidence of a direct dietary effect. plain_language: Competition for a precursor can alter a neurotransmitter-related metabolic pool. organism: Rat neurons and astroglia tissue_or_cell_type: Glutamine transport and extracellular glutamate experimental_model: Radiotracer uptake in synaptosomes and cultured neural cells limitations: High cell concentrations; 10 mM is far above the approximately 25 micromolar plasma peak in the separate human 100 mg study. Different cells from the system L screen; no claim all routes are sodium-dependent. exposure: Theanine 0.1-10 millimolar in uptake assays; sustained 10 millimolar for glutamate release evidence_span: {"source_cache": "artifacts/theanine-research/18293419.abstract.txt", "locator": "Primary indexed abstract; zero-based, end-exclusive Unicode character offsets", "file_sha256": "c94471071feadec8a04eafa7e9d53999dd9756b7f1d5dc1f351152b9b5f4b5d3", "start_char": 0, "end_char": 1751, "text_sha256": "c94471071feadec8a04eafa7e9d53999dd9756b7f1d5dc1f351152b9b5f4b5d3"} [theanine-p18293419] Theanine, an ingredient of green tea, inhibits [3H]glutamine transport in neurons and astroglia in rat brain. (2008). https://pubmed.ncbi.nlm.nih.gov/18293419/ DOI: 10.1002/jnr.21637
Complete structured claim and evidence
The events it takes part in
A mechanism often involves more than two components. These are the full events, with every participant and its role.
Situations it appears in
Low-supply and faulty-machinery situations recorded in the chapters where this component plays a part.
In the sources
Preserved passages that mention this component, quoted exactly. Open one to read it in context.
Open hypotheses
Proposed ideas that involve this component. They are labeled as hypotheses and do not change any recorded statement.
This is a research prototype built from draft material. It is not medical advice, and its statements still await verification against the original studies.