Component
AREDS2 composite cognitive function score
AREDS2 composite cognitive function score. Species, exposure and limitations are retained in each linked claim.
1 recorded relationships. Experimental role, claim status and evidence remain attached to each record.
How nutrients influence it
Every nutrient with a recorded effect on this component, credited to the nutrient that acted rather than the chapter that recorded it. Open a nutrient to see the findings and the conditions they were measured under.
Other things that act on it
Enzymes, hormones, genes, and other components with a recorded effect. These are not nutrients, so they do not count toward the arrows above. Each finding names the chapter that recorded it.
How nutrients reach it in more than one step
Chains of two or more recorded steps that end here, grouped by the nutrient they start from. Each step is a separate finding, so a chain is a route a mechanism could take, not proof that it does.
Tracing routes…
What it does
Every recorded relationship this component is part of, grouped by its role. Plain wording comes first; the technical statement follows.
What acts on it
L+Z produced no significant difference in yearly cognitive composite change: 0.03 (99% CI −0.14 to 0.19; P=0.66).
Experimental context and source evidence
- evidence_span
- {"source_cache": "artifacts/lutein-research/26305649.abstract.txt", "locator": "Primary indexed abstract; zero-based, end-exclusive Unicode character offsets", "file_sha256": "6b4498bace6ac4564fae52aef2f95e564154631bdfa1e19b02fa6878043dbe72", "start_char": 0, "end_char": 2936, "text_sha256": "6b4498bace6ac4564fae52aef2f95e564154631bdfa1e19b02fa6878043dbe72"}
- experimental_model
- AREDS2 ancillary randomized cognitive study
- exposure
- L+Z 10/2 mg daily; five-year study on background nutrient formulas
- limitations
- Cognitive outcome, not a direct brain-lutein assay; no attribution to isolated lutein.
- nutrient_topic
- Lutein research collection; topical membership is not evidence of a direct dietary effect. · Lutein
- organism
- 3501 tested older participants at AMD risk
- plain_language
- The large older-adult study did not show cognitive benefit.
- primary_references
- [lutein-p26305649] Effect of Omega-3 Fatty Acids, Lutein/Zeaxanthin, or Other Nutrient Supplementation on Cognitive Function: The AREDS2 Randomized Clinical Trial. (2015). https://pubmed.ncbi.nlm.nih.gov/26305649/ DOI: 10.1001/jama.2015.9677
- tissue_or_cell_type
- Telephone cognitive test battery
Lutein: metabolism, signaling and nutrient connections (2026-09-17) · lines 892–903
AI-assisted literature curation; primary study URLs and scope retained in the document and extraction. Not publisher full text. · supports · AREDS2 ancillary randomized cognitive study · source_derived_draft · unverified_draft
### lutein-cognition-areds-null L+Z produced no significant difference in yearly cognitive composite change: 0.03 (99% CI −0.14 to 0.19; P=0.66). Condition category: normal nutrient_topic: Lutein research collection; topical membership is not evidence of a direct dietary effect. plain_language: The large older-adult study did not show cognitive benefit. organism: 3501 tested older participants at AMD risk tissue_or_cell_type: Telephone cognitive test battery experimental_model: AREDS2 ancillary randomized cognitive study limitations: Cognitive outcome, not a direct brain-lutein assay; no attribution to isolated lutein. exposure: L+Z 10/2 mg daily; five-year study on background nutrient formulas evidence_span: {"source_cache": "artifacts/lutein-research/26305649.abstract.txt", "locator": "Primary indexed abstract; zero-based, end-exclusive Unicode character offsets", "file_sha256": "6b4498bace6ac4564fae52aef2f95e564154631bdfa1e19b02fa6878043dbe72", "start_char": 0, "end_char": 2936, "text_sha256": "6b4498bace6ac4564fae52aef2f95e564154631bdfa1e19b02fa6878043dbe72"} [lutein-p26305649] Effect of Omega-3 Fatty Acids, Lutein/Zeaxanthin, or Other Nutrient Supplementation on Cognitive Function: The AREDS2 Randomized Clinical Trial. (2015). https://pubmed.ncbi.nlm.nih.gov/26305649/ DOI: 10.1001/jama.2015.9677
Complete structured claim and evidence
The events it takes part in
A mechanism often involves more than two components. These are the full events, with every participant and its role.
Situations it appears in
Low-supply and faulty-machinery situations recorded in the chapters where this component plays a part.
In the sources
Preserved passages that mention this component, quoted exactly. Open one to read it in context.
Open hypotheses
Proposed ideas that involve this component. They are labeled as hypotheses and do not change any recorded statement.
This is a research prototype built from draft material. It is not medical advice, and its statements still await verification against the original studies.