Component
Unconjugated apigenin measured in human plasma
Unconjugated apigenin measured in human plasma
1 recorded relationships. Experimental role, claim status and evidence remain attached to each record.
How nutrients influence it
Every nutrient with a recorded effect on this component, credited to the nutrient that acted rather than the chapter that recorded it. Open a nutrient to see the findings and the conditions they were measured under.
Other things that act on it
Enzymes, hormones, genes, and other components with a recorded effect. These are not nutrients, so they do not count toward the arrows above. Each finding names the chapter that recorded it.
How nutrients reach it in more than one step
Chains of two or more recorded steps that end here, grouped by the nutrient they start from. Each step is a separate finding, so a chain is a route a mechanism could take, not proof that it does.
Tracing routes…
What it does
Every recorded relationship this component is part of, grouped by its role. Plain wording comes first; the technical statement follows.
What acts on it
After ingestion of 191 micromoles of apigenin, neither parent nor the targeted conjugates were detected in plasma at 0, 2, 4 or 6 hours.
Experimental context and source evidence
- evidence_access
- Full original primary-paper PDF, Methods, Results and Tables 1–7 reviewed; authentic-standard HPLC-MS analysis. PDF obtained from a public mirror; DOI and article identity verified.
- experimental_contrast
- {"intervention": "191 micromoles oral apigenin", "comparator": "Predose plasma", "endpoint": "After ingestion of 191 micromoles of apigenin, neither parent nor the targeted conjugates were detected in plasma at 0, 2, 4 or 6 hours.", "effect_direction": "no_detected_change", "combination": "single", "conditions": []} Explicit extracted experimental comparison; recorded from source.
- experimental_model
- Three healthy men; single aglycone capsule contents in hot water; about 51.6 mg calculated from molecular mass.
- interpretation_status
- Recorded from source with stated access limits; ungraded, not independent replication.
- limitations
- Limited to the recorded preparation, model, exposure and endpoint. Does not establish a human dietary deficiency, clinical benefit or unique molecular mediation.
- nutrient_topic
- Apigenin collection; exact intervention and molecular form govern interpretation. · Apigenin
- plain_language
- After ingestion of 191 micromoles of apigenin, neither parent nor the targeted conjugates were detected in plasma at 0, 2, 4 or 6 hours.
- primary_references
- Absorption, distribution, metabolism and excretion of apigenin and its glycosides in healthy male adults. | https://pubmed.ncbi.nlm.nih.gov/35452808/ | https://doi.org/10.1016/j.freeradbiomed.2022.04.007
- source_locator
- Reviewed reference api-parent-pk-null; Table 3 and section 3.3.1. Detection was sampling- and assay-dependent, not proof of zero absorption.
Apigenin: detailed mechanisms of action (reviewed 10 October 2026) · lines 29–35
AI-assisted original curation of primary studies; claim-local access and experimental limitations stated. Includes original-draft correction history. No independent replication claimed. · supports · Three healthy men; single aglycone capsule contents in hot water; about 51.6 mg calculated from molecular mass. · Recorded from source · Recorded from source
### api-parent-pk-null After ingestion of 191 micromoles of apigenin, neither parent nor the targeted conjugates were detected in plasma at 0, 2, 4 or 6 hours. Table 3 and section 3.3.1. Detection was sampling- and assay-dependent, not proof of zero absorption. Model and exposure: Three healthy men; single aglycone capsule contents in hot water; about 51.6 mg calculated from molecular mass. Limitations: Limited to the recorded preparation, model, exposure and endpoint. Does not establish a human dietary deficiency, clinical benefit or unique molecular mediation. Reference: Absorption, distribution, metabolism and excretion of apigenin and its glycosides in healthy male adults. | 2022 | https://pubmed.ncbi.nlm.nih.gov/35452808/ | https://doi.org/10.1016/j.freeradbiomed.2022.04.007 | Access: Full original primary-paper PDF, Methods, Results and Tables 1–7 reviewed; authentic-standard HPLC-MS analysis. PDF obtained from a public mirror; DOI and article identity verified.
Complete structured claim and evidence
The events it takes part in
A mechanism often involves more than two components. These are the full events, with every participant and its role.
Situations it appears in
Low-supply and faulty-machinery situations recorded in the chapters where this component plays a part.
In the sources
Preserved passages that mention this component, quoted exactly. Open one to read it in context.
Open hypotheses
Proposed ideas that involve this component. They are labeled as hypotheses and do not change any recorded statement.
This is a research prototype built from draft material. It is not medical advice, and its statements still await verification against the original studies.