Component
Plasma apigenin equivalents after sample deconjugation
Plasma apigenin equivalents after sample deconjugation
1 recorded relationships. Experimental role, claim status and evidence remain attached to each record.
How nutrients influence it
Every nutrient with a recorded effect on this component, credited to the nutrient that acted rather than the chapter that recorded it. Open a nutrient to see the findings and the conditions they were measured under.
Other things that act on it
Enzymes, hormones, genes, and other components with a recorded effect. These are not nutrients, so they do not count toward the arrows above. Each finding names the chapter that recorded it.
How nutrients reach it in more than one step
Chains of two or more recorded steps that end here, grouped by the nutrient they start from. Each step is a separate finding, so a chain is a route a mechanism could take, not proof that it does.
Tracing routes…
What it does
Every recorded relationship this component is part of, grouped by its role. Plain wording comes first; the technical statement follows.
What acts on it
The older parsley study reported a plasma peak of 127 ± 81 nM at 7.2 ± 1.3 hours and urinary recovery of 0.22 ± 0.16% of intake.
Experimental context and source evidence
- evidence_access
- Indexed primary abstract/metadata only; unextracted doses, figures and methods remain unknown.; Full original primary-paper PDF, Methods, Results and Tables 1–7 reviewed; authentic-standard HPLC-MS analysis. PDF obtained from a public mirror; DOI and article identity verified.
- experimental_model
- Eleven volunteers; 2 g blanched parsley/kg body weight.
- interpretation_status
- Recorded from source with stated access limits; ungraded, not independent replication.
- limitations
- Limited to the recorded preparation, model, exposure and endpoint. Does not establish a human dietary deficiency, clinical benefit or unique molecular mediation.
- nutrient_topic
- Apigenin collection; exact intervention and molecular form govern interpretation. · Apigenin
- plain_language
- The older parsley study reported a plasma peak of 127 ± 81 nM at 7.2 ± 1.3 hours and urinary recovery of 0.22 ± 0.16% of intake.
- primary_references
- Absorption, distribution, metabolism and excretion of apigenin and its glycosides in healthy male adults. | https://pubmed.ncbi.nlm.nih.gov/35452808/ | https://doi.org/10.1016/j.freeradbiomed.2022.04.007
- primary_references
- Bioavailability of apigenin from apiin-rich parsley in humans. | https://pubmed.ncbi.nlm.nih.gov/16407641/ | https://doi.org/10.1159/000090736
- source_locator
- Reviewed reference api-older-parsley-pk; The 2022 primary paper identifies glucuronidase/sulfatase sample pretreatment in this earlier method. These results cannot be read as directly measured unbound parent. Food matrix and analytical methods differ between studies.
Apigenin: detailed mechanisms of action (reviewed 10 October 2026) · lines 85–92
AI-assisted original curation of primary studies; claim-local access and experimental limitations stated. Includes original-draft correction history. No independent replication claimed. · supports · Eleven volunteers; 2 g blanched parsley/kg body weight. · Recorded from source · Recorded from source
### api-older-parsley-pk The older parsley study reported a plasma peak of 127 ± 81 nM at 7.2 ± 1.3 hours and urinary recovery of 0.22 ± 0.16% of intake. The 2022 primary paper identifies glucuronidase/sulfatase sample pretreatment in this earlier method. These results cannot be read as directly measured unbound parent. Food matrix and analytical methods differ between studies. Model and exposure: Eleven volunteers; 2 g blanched parsley/kg body weight. Limitations: Limited to the recorded preparation, model, exposure and endpoint. Does not establish a human dietary deficiency, clinical benefit or unique molecular mediation. Reference: Bioavailability of apigenin from apiin-rich parsley in humans. | 2006 | https://pubmed.ncbi.nlm.nih.gov/16407641/ | https://doi.org/10.1159/000090736 | Access: Indexed primary abstract/metadata only; unextracted doses, figures and methods remain unknown. Reference: Absorption, distribution, metabolism and excretion of apigenin and its glycosides in healthy male adults. | 2022 | https://pubmed.ncbi.nlm.nih.gov/35452808/ | https://doi.org/10.1016/j.freeradbiomed.2022.04.007 | Access: Full original primary-paper PDF, Methods, Results and Tables 1–7 reviewed; authentic-standard HPLC-MS analysis. PDF obtained from a public mirror; DOI and article identity verified.
Complete structured claim and evidence
The events it takes part in
A mechanism often involves more than two components. These are the full events, with every participant and its role.
Situations it appears in
Low-supply and faulty-machinery situations recorded in the chapters where this component plays a part.
In the sources
Preserved passages that mention this component, quoted exactly. Open one to read it in context.
Open hypotheses
Proposed ideas that involve this component. They are labeled as hypotheses and do not change any recorded statement.
This is a research prototype built from draft material. It is not medical advice, and its statements still await verification against the original studies.