{"id":"223f77a8-d99f-52ea-a453-aadb71c6fdea","stable_key":"ff370329-68a3-573d-96ee-597de78a3967:api-older-parsley-pk","predicate":"reported_relationship","statement":"The older parsley study reported a plasma peak of 127 ± 81 nM at 7.2 ± 1.3 hours and urinary recovery of 0.22 ± 0.16% of intake.","claim_class":"observational","status":"source_recorded","evidence_grade":"ungraded","direction":"neutral","is_public":true,"mechanism_event_id":"c3987a58-f1ef-5777-ae39-c226de86a3ab","mechanism_event_label":"The older parsley study reported a plasma peak of 127 ± 81 nM at 7.2 ± 1.3 hours and urinary recovery of 0.22 ± 0.16% of intake.","subject":{"id":"072c2270-7098-5c0d-beb3-52635ff42a2b","slug":"apigenin-parsley-meal-2006","display_name":"Blanched parsley meal in the 2006 apigenin study","entity_type_key":"botanical"},"object":{"id":"1b0e4ee4-8d12-5163-b07c-436a3c98e7e3","slug":"apigenin-human-deconjugated-measurement","display_name":"Plasma apigenin equivalents after sample deconjugation","entity_type_key":"cellular_process"},"evidence_count":1,"mechanism_event":{"id":"c3987a58-f1ef-5777-ae39-c226de86a3ab","stable_key":"ff370329-68a3-573d-96ee-597de78a3967:api-older-parsley-pk-event","event_type":"experimental_observation","label":"The older parsley study reported a plasma peak of 127 ± 81 nM at 7.2 ± 1.3 hours and urinary recovery of 0.22 ± 0.16% of intake.","description":"### api-older-parsley-pk\n\nThe older parsley study reported a plasma peak of 127 ± 81 nM at 7.2 ± 1.3 hours and urinary recovery of 0.22 ± 0.16% of intake.\nThe 2022 primary paper identifies glucuronidase/sulfatase sample pretreatment in this earlier method. These results cannot be read as directly measured unbound parent. Food matrix and analytical methods differ between studies.\nModel and exposure: Eleven volunteers; 2 g blanched parsley/kg body weight.\nLimitations: Limited to the recorded preparation, model, exposure and endpoint. Does not establish a human dietary deficiency, clinical benefit or unique molecular mediation.\nReference: Bioavailability of apigenin from apiin-rich parsley in humans. | 2006 | https://pubmed.ncbi.nlm.nih.gov/16407641/ | https://doi.org/10.1159/000090736 | Access: Indexed primary abstract/metadata only; unextracted doses, figures and methods remain unknown.\nReference: Absorption, distribution, metabolism and excretion of apigenin and its glycosides in healthy male adults. | 2022 | https://pubmed.ncbi.nlm.nih.gov/35452808/ | https://doi.org/10.1016/j.freeradbiomed.2022.04.007 | Access: Full original primary-paper PDF, Methods, Results and Tables 1–7 reviewed; authentic-standard HPLC-MS analysis. PDF obtained from a public mirror; DOI and article identity verified.","status":"provisional","compartment":null,"participants":[{"entity":{"id":"072c2270-7098-5c0d-beb3-52635ff42a2b","slug":"apigenin-parsley-meal-2006","display_name":"Blanched parsley meal in the 2006 apigenin study","entity_type_key":"botanical"},"role":"recorded factor","stoichiometry":null,"state_label":"as reported","sequence_order":0,"notes":""},{"entity":{"id":"1b0e4ee4-8d12-5163-b07c-436a3c98e7e3","slug":"apigenin-human-deconjugated-measurement","display_name":"Plasma apigenin equivalents after sample deconjugation","entity_type_key":"cellular_process"},"role":"measured outcome","stoichiometry":null,"state_label":"not_reported","sequence_order":1,"notes":""},{"entity":{"id":"4425961f-4764-56d3-9887-87e47749379b","slug":"apigenin","display_name":"Apigenin","entity_type_key":"small_molecule"},"role":"measured aglycone after processing","stoichiometry":null,"state_label":"","sequence_order":2,"notes":""}]},"contexts":[{"dimension":"evidence_access","value_text":"Indexed primary abstract/metadata only; unextracted doses, figures and methods remain unknown.; Full original primary-paper PDF, Methods, Results and Tables 1–7 reviewed; authentic-standard HPLC-MS analysis. PDF obtained from a public mirror; DOI and article identity verified.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"experimental_model","value_text":"Eleven volunteers; 2 g blanched parsley/kg body weight.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"interpretation_status","value_text":"Recorded from source with stated access limits; ungraded, not independent replication.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"limitations","value_text":"Limited to the recorded preparation, model, exposure and endpoint. Does not establish a human dietary deficiency, clinical benefit or unique molecular mediation.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"nutrient_topic","value_text":"Apigenin collection; exact intervention and molecular form govern interpretation.","comparator":null,"unit":null,"notes":"","entity":{"slug":"apigenin","display_name":"Apigenin","entity_type_key":"small_molecule"}},{"dimension":"plain_language","value_text":"The older parsley study reported a plasma peak of 127 ± 81 nM at 7.2 ± 1.3 hours and urinary recovery of 0.22 ± 0.16% of intake.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"primary_references","value_text":"Absorption, distribution, metabolism and excretion of apigenin and its glycosides in healthy male adults. | https://pubmed.ncbi.nlm.nih.gov/35452808/ | https://doi.org/10.1016/j.freeradbiomed.2022.04.007","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"primary_references","value_text":"Bioavailability of apigenin from apiin-rich parsley in humans. | https://pubmed.ncbi.nlm.nih.gov/16407641/ | https://doi.org/10.1159/000090736","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"source_locator","value_text":"Reviewed reference api-older-parsley-pk; The 2022 primary paper identifies glucuronidase/sulfatase sample pretreatment in this earlier method. These results cannot be read as directly measured unbound parent. Food matrix and analytical methods differ between studies.","comparator":null,"unit":null,"notes":"","entity":null}],"evidence":[{"id":"87448e05-b1a8-5fac-b983-3c75a0b21de1","evidence_kind":"source_excerpt","locator":"Lines 85-92","start_line":85,"end_line":92,"excerpt":"### api-older-parsley-pk\n\nThe older parsley study reported a plasma peak of 127 ± 81 nM at 7.2 ± 1.3 hours and urinary recovery of 0.22 ± 0.16% of intake.\nThe 2022 primary paper identifies glucuronidase/sulfatase sample pretreatment in this earlier method. These results cannot be read as directly measured unbound parent. Food matrix and analytical methods differ between studies.\nModel and exposure: Eleven volunteers; 2 g blanched parsley/kg body weight.\nLimitations: Limited to the recorded preparation, model, exposure and endpoint. Does not establish a human dietary deficiency, clinical benefit or unique molecular mediation.\nReference: Bioavailability of apigenin from apiin-rich parsley in humans. | 2006 | https://pubmed.ncbi.nlm.nih.gov/16407641/ | https://doi.org/10.1159/000090736 | Access: Indexed primary abstract/metadata only; unextracted doses, figures and methods remain unknown.\nReference: Absorption, distribution, metabolism and excretion of apigenin and its glycosides in healthy male adults. | 2022 | https://pubmed.ncbi.nlm.nih.gov/35452808/ | https://doi.org/10.1016/j.freeradbiomed.2022.04.007 | Access: Full original primary-paper PDF, Methods, Results and Tables 1–7 reviewed; authentic-standard HPLC-MS analysis. PDF obtained from a public mirror; DOI and article identity verified.","model_system":"Eleven volunteers; 2 g blanched parsley/kg body weight.","directness":"reported_statement","verification_status":"source_recorded","notes":"Original paraphrase in the retained reviewed reference, not a verbatim primary-paper quotation. Access level is explicit.","relationship":"supports","weight":1.0,"link_notes":"","source":{"id":"54eac90b-add1-5f56-9036-d900307c5697","stable_key":"import-ff370329-68a3-573d-96ee-597de78a3967","title":"Apigenin: detailed mechanisms of action (reviewed 10 October 2026)","document_type":"imported_text","citation_label":"AI-assisted original curation of primary studies; claim-local access and experimental limitations stated. Includes original-draft correction history. No independent replication claimed.","file_path":"","sha256":"ede6e5c6b91d66b66844f2ff667a7f8303d9ac1281f15dc09db703f7de4da942","revision_id":"b41a39a2-0197-549c-97a5-1765e6696931","review_status":"source_recorded","notes":""}}],"relations":[],"conflicts":[],"corrections":[],"research":null}