Component

Musculoskeletal outcomes in aged NMN/apigenin-treated mice

Musculoskeletal outcomes in aged NMN/apigenin-treated mice

2 recorded relationships. Experimental role, claim status and evidence remain attached to each record.

Read recorded mechanisms Open recursive mind map

How nutrients influence it

Every nutrient with a recorded effect on this component, credited to the nutrient that acted rather than the chapter that recorded it. Open a nutrient to see the findings and the conditions they were measured under.

How nutrients reach it in more than one step

Chains of two or more recorded steps that end here, grouped by the nutrient they start from. Each step is a separate finding, so a chain is a route a mechanism could take, not proof that it does.

Tracing routes…

What it does

Every recorded relationship this component is part of, grouped by its role. Plain wording comes first; the technical statement follows.

Recorded relationships

What acts on it

  1. Oral NMN plus apigenin improved cartilage, bone, muscle and motor readouts in the 20-month-old mouse study.

    NMN plus apigenin preparation in the 2026 musculoskeletal study → Musculoskeletal outcomes in aged NMN/apigenin-treated mice Recorded from sourceungraded
    Experimental context and source evidence
    evidence_access
    Primary main-text Results and figure descriptions reviewed. Detailed supporting Methods/supplements inaccessible; exact doses and preparation details not independently extracted.
    experimental_condition
    Aged untreated/control mice co-administered · Apigenin Condition belongs to the full experimental contrast; do not separate a joint intervention.
    experimental_condition
    Aged untreated/control mice Oral combined preparation · NMN plus apigenin preparation in the 2026 musculoskeletal study Condition belongs to the full experimental contrast; do not separate a joint intervention.
    experimental_condition
    Aged untreated/control mice co-administered · NMN Condition belongs to the full experimental contrast; do not separate a joint intervention.
    experimental_contrast
    {"intervention": "Oral combined preparation", "comparator": "Aged untreated/control mice", "endpoint": "Oral NMN plus apigenin improved cartilage, bone, muscle and motor readouts in the 20-month-old mouse study.", "effect_direction": "increase", "combination": "joint", "conditions": [{"entity_slug": "nmn-apigenin-combination-2026", "state": "Oral combined preparation"}, {"entity_slug": "nmn", "state": "co-administered"}, {"entity_slug": "apigenin", "state": "co-administered"}]} Explicit extracted experimental comparison; recorded from source.
    experimental_model
    Aged mice; detailed supplement Methods not obtained.
    interpretation_status
    Recorded from source with stated access limits; ungraded, not independent replication.
    limitations
    Limited to the recorded preparation, model, exposure and endpoint. Does not establish a human dietary deficiency, clinical benefit or unique molecular mediation.
    nutrient_topic
    Apigenin collection; exact intervention and molecular form govern interpretation. · Apigenin
    plain_language
    Oral NMN plus apigenin improved cartilage, bone, muscle and motor readouts in the 20-month-old mouse study.
    primary_references
    Double-Pronged NAD Preservation: Delaying Cellular Senescence and Initiating Musculoskeletal Regeneration. | https://pubmed.ncbi.nlm.nih.gov/41944220/ | https://pmc.ncbi.nlm.nih.gov/articles/PMC13054677/ | https://doi.org/10.1111/acel.70468
    source_locator
    Reviewed reference api-nmn-aged-mice; No human combination efficacy is demonstrated.

    Apigenin: detailed mechanisms of action (reviewed 10 October 2026) · lines 548–554

    AI-assisted original curation of primary studies; claim-local access and experimental limitations stated. Includes original-draft correction history. No independent replication claimed. · supports · Aged mice; detailed supplement Methods not obtained. · Recorded from source · Recorded from source

    ### api-nmn-aged-mice Oral NMN plus apigenin improved cartilage, bone, muscle and motor readouts in the 20-month-old mouse study. No human combination efficacy is demonstrated. Model and exposure: Aged mice; detailed supplement Methods not obtained. Limitations: Limited to the recorded preparation, model, exposure and endpoint. Does not establish a human dietary deficiency, clinical benefit or unique molecular mediation. Reference: Double-Pronged NAD Preservation: Delaying Cellular Senescence and Initiating Musculoskeletal Regeneration. | 2026 | https://pubmed.ncbi.nlm.nih.gov/41944220/ | https://pmc.ncbi.nlm.nih.gov/articles/PMC13054677/ | https://doi.org/10.1111/acel.70468 | Access: Primary main-text Results and figure descriptions reviewed. Detailed supporting Methods/supplements inaccessible; exact doses and preparation details not independently extracted.
    Complete structured claim and evidence

  2. Sirt3 deletion partially attenuated the structural and functional benefits of NMN plus apigenin.

    NMN plus apigenin preparation in the 2026 musculoskeletal study → Musculoskeletal outcomes in aged NMN/apigenin-treated mice Recorded from sourceungraded
    Experimental context and source evidence
    availability_state
    machinery_impairment Imported condition classification; unverified.
    evidence_access
    Primary main-text Results and figure descriptions reviewed. Detailed supporting Methods/supplements inaccessible; exact doses and preparation details not independently extracted.
    experimental_condition
    Combined-preparation response in wild-type mice co-administered · Apigenin Condition belongs to the full experimental contrast; do not separate a joint intervention.
    experimental_condition
    Combined-preparation response in wild-type mice Combined preparation in Sirt3-knockout mice · NMN plus apigenin preparation in the 2026 musculoskeletal study Condition belongs to the full experimental contrast; do not separate a joint intervention.
    experimental_condition
    Combined-preparation response in wild-type mice genetically absent · Mouse mitochondrial sirtuin 3 / Sirt3 Condition belongs to the full experimental contrast; do not separate a joint intervention.
    experimental_condition
    Combined-preparation response in wild-type mice co-administered · NMN Condition belongs to the full experimental contrast; do not separate a joint intervention.
    experimental_contrast
    {"intervention": "Combined preparation in Sirt3-knockout mice", "comparator": "Combined-preparation response in wild-type mice", "endpoint": "Sirt3 deletion partially attenuated the structural and functional benefits of NMN plus apigenin.", "effect_direction": "decrease", "combination": "joint", "conditions": [{"entity_slug": "nmn-apigenin-combination-2026", "state": "Combined preparation in Sirt3-knockout mice"}, {"entity_slug": "nmn", "state": "co-administered"}, {"entity_slug": "apigenin", "state": "co-administered"}, {"entity_slug": "mouse-sirt3", "state": "genetically absent"}]} Explicit extracted experimental comparison; recorded from source.
    experimental_model
    Aged-mouse genotype comparison.
    interpretation_status
    Recorded from source with stated access limits; ungraded, not independent replication.
    limitations
    Limited to the recorded preparation, model, exposure and endpoint. Does not establish a human dietary deficiency, clinical benefit or unique molecular mediation.
    nutrient_topic
    Apigenin collection; exact intervention and molecular form govern interpretation. · Apigenin
    plain_language
    Sirt3 deletion partially attenuated the structural and functional benefits of NMN plus apigenin.
    primary_references
    Double-Pronged NAD Preservation: Delaying Cellular Senescence and Initiating Musculoskeletal Regeneration. | https://pubmed.ncbi.nlm.nih.gov/41944220/ | https://pmc.ncbi.nlm.nih.gov/articles/PMC13054677/ | https://doi.org/10.1111/acel.70468
    source_locator
    Reviewed reference api-nmn-sirt3-benefit-attenuated; Partial attenuation supports a contributing requirement; it is not complete elimination or direct apigenin binding to SIRT3.
    trigger_kind
    machinery_impairment Imported condition classification; unverified.

    Apigenin: detailed mechanisms of action (reviewed 10 October 2026) · lines 564–570

    AI-assisted original curation of primary studies; claim-local access and experimental limitations stated. Includes original-draft correction history. No independent replication claimed. · supports · Aged-mouse genotype comparison. · Recorded from source · Recorded from source

    ### api-nmn-sirt3-benefit-attenuated Sirt3 deletion partially attenuated the structural and functional benefits of NMN plus apigenin. Partial attenuation supports a contributing requirement; it is not complete elimination or direct apigenin binding to SIRT3. Model and exposure: Aged-mouse genotype comparison. Limitations: Limited to the recorded preparation, model, exposure and endpoint. Does not establish a human dietary deficiency, clinical benefit or unique molecular mediation. Reference: Double-Pronged NAD Preservation: Delaying Cellular Senescence and Initiating Musculoskeletal Regeneration. | 2026 | https://pubmed.ncbi.nlm.nih.gov/41944220/ | https://pmc.ncbi.nlm.nih.gov/articles/PMC13054677/ | https://doi.org/10.1111/acel.70468 | Access: Primary main-text Results and figure descriptions reviewed. Detailed supporting Methods/supplements inaccessible; exact doses and preparation details not independently extracted.
    Complete structured claim and evidence

In the sources

Preserved passages that mention this component, quoted exactly. Open one to read it in context.

    This is a research prototype built from draft material. It is not medical advice, and its statements still await verification against the original studies.