Component
5-Lipoxygenase nuclear translocation
Stimulus-dependent redistribution of human 5-LOX from cytosolic to nuclear fractions.
1 recorded relationships. Experimental role, claim status and evidence remain attached to each record.
How nutrients influence it
Every nutrient with a recorded effect on this component, credited to the nutrient that acted rather than the chapter that recorded it. Open a nutrient to see the findings and the conditions they were measured under.
Other things that act on it
Enzymes, hormones, genes, and other components with a recorded effect. These are not nutrients, so they do not count toward the arrows above. Each finding names the chapter that recorded it.
How nutrients reach it in more than one step
Chains of two or more recorded steps that end here, grouped by the nutrient they start from. Each step is a separate finding, so a chain is a route a mechanism could take, not proof that it does.
Tracing routes…
What it does
Every recorded relationship this component is part of, grouped by its role. Plain wording comes first; the technical statement follows.
What acts on it
Delta-tocopherol pretreatment largely prevented A23187-induced redistribution of 5-LOX from cytosolic to nuclear fractions in differentiated HL-60 cells.
Experimental context and source evidence
- cross_nutrient
- false
- experimental_model
- DMSO-differentiated human HL-60 neutrophil-like cells; fractionation and immunoblot
- exposure
- 50 µM delta-tocopherol for 10 min followed by 2.5 µM A23187 for 15 min.
- limitations
- Fractionation is a localization assay, not proof of direct enzyme inhibition; purified 5-LOX was unaffected by tocopherols at 50 µM in this paper.
- nutrient_topic
- Vitamin E research collection; topical membership is not evidence of a direct dietary effect. · Vitamin E
- organism
- Homo sapiens
- plain_language
- Delta-tocopherol kept much of the enzyme from moving to the cell location associated with leukotriene production.
- primary_references
- [jiang2011] Natural forms of vitamin E and 13'-carboxychromanol, a long-chain vitamin E metabolite, inhibit leukotriene generation from stimulated neutrophils by blocking calcium influx and suppressing 5-lipoxygenase activity, respectively. (2011). https://pubmed.ncbi.nlm.nih.gov/21169551/ DOI: 10.4049/jimmunol.1002342
- tissue_or_cell_type
- Neutrophil-like leukemia-derived cell culture
Vitamin E: transport, membrane protection and nutrient interactions (2026-09-17) · lines 907–918
AI-assisted literature curation; primary study URLs and scope retained in the document and extraction. Not publisher full text. · supports · DMSO-differentiated human HL-60 neutrophil-like cells; fractionation and immunoblot · source_derived_draft · unverified_draft
### e-sig-delta-lox-translocation Delta-tocopherol pretreatment largely prevented A23187-induced redistribution of 5-LOX from cytosolic to nuclear fractions in differentiated HL-60 cells. Condition category: normal nutrient_topic: Vitamin E research collection; topical membership is not evidence of a direct dietary effect. plain_language: Delta-tocopherol kept much of the enzyme from moving to the cell location associated with leukotriene production. organism: Homo sapiens tissue_or_cell_type: Neutrophil-like leukemia-derived cell culture experimental_model: DMSO-differentiated human HL-60 neutrophil-like cells; fractionation and immunoblot limitations: Fractionation is a localization assay, not proof of direct enzyme inhibition; purified 5-LOX was unaffected by tocopherols at 50 µM in this paper. exposure: 50 µM delta-tocopherol for 10 min followed by 2.5 µM A23187 for 15 min. cross_nutrient: false [jiang2011] Natural forms of vitamin E and 13'-carboxychromanol, a long-chain vitamin E metabolite, inhibit leukotriene generation from stimulated neutrophils by blocking calcium influx and suppressing 5-lipoxygenase activity, respectively. (2011). https://pubmed.ncbi.nlm.nih.gov/21169551/ DOI: 10.4049/jimmunol.1002342
Complete structured claim and evidence
The events it takes part in
A mechanism often involves more than two components. These are the full events, with every participant and its role.
Situations it appears in
Low-supply and faulty-machinery situations recorded in the chapters where this component plays a part.
In the sources
Preserved passages that mention this component, quoted exactly. Open one to read it in context.
Open hypotheses
Proposed ideas that involve this component. They are labeled as hypotheses and do not change any recorded statement.
This is a research prototype built from draft material. It is not medical advice, and its statements still await verification against the original studies.