Component
Acute respiratory tract infection incidence
Study-defined Acute respiratory tract infection incidence. Read each linked record for species, exposure and endpoint.
1 recorded relationships. Experimental role, claim status and evidence remain attached to each record.
How nutrients influence it
Every nutrient with a recorded effect on this component, credited to the nutrient that acted rather than the chapter that recorded it. Open a nutrient to see the findings and the conditions they were measured under.
Other things that act on it
Enzymes, hormones, genes, and other components with a recorded effect. These are not nutrients, so they do not count toward the arrows above. Each finding names the chapter that recorded it.
How nutrients reach it in more than one step
Chains of two or more recorded steps that end here, grouped by the nutrient they start from. Each step is a separate finding, so a chain is a route a mechanism could take, not proof that it does.
Tracing routes…
What it does
Every recorded relationship this component is part of, grouped by its role. Plain wording comes first; the technical statement follows.
What acts on it
At least one confirmed respiratory infection occurred in 4.6% of no-offer, 5.7% of lower-dose-offer and 5.0% of higher-dose-offer participants; ORs 1.26 (95% CI0.96–1.66) and 1.09 (0.82–1.46).
Experimental context and source evidence
- cross_nutrient
- false
- experimental_model
- CORONAVIT pragmatic randomized open-label offer-to-test-and-treat trial; 6200UKadults≥ 16
- exposure
- Offer 800 or 3200 IU/day vitamin D for 6 months if 25(OH)D<75 nmol/L versus no offer; 2674 of 3100 offered received supplements.
- limitations
- Open-label strategy trial; receipt, outside supplementation and pandemic context limit inference about specific cellular mechanisms or all dosing regimens.
- nutrient_topic
- Vitamin D2 and D3 research collection; topical membership is not evidence of a direct dietary effect. · Vitamin D2 and D3
- organism
- Homo sapiens
- plain_language
- Offering this test-and-supplement strategy did not reduce confirmed respiratory infections.
- primary_references
- [jolliffe2022] Effect of a test-and-treat approach to vitamin D supplementation on risk of all cause acute respiratory tract infection and covid-19: phase 3 randomised controlled trial (CORONAVIT). (2022). https://pubmed.ncbi.nlm.nih.gov/36215226/ DOI: 10.1136/bmj-2022-071230
- tissue_or_cell_type
- Clinical respiratory outcomes
Vitamin D2 and D3: mechanisms, deficiency and nutrient interactions (2026-09-17) · lines 1652–1663
AI-assisted literature curation; primary study URLs and scope retained in the document and extraction. Not publisher full text. · supports · CORONAVIT pragmatic randomized open-label offer-to-test-and-treat trial; 6200UKadults≥ 16 · source_derived_draft · unverified_draft
### vd-coronavit-ari At least one confirmed respiratory infection occurred in 4.6% of no-offer, 5.7% of lower-dose-offer and 5.0% of higher-dose-offer participants; ORs 1.26 (95% CI0.96–1.66) and 1.09 (0.82–1.46). Condition category: normal nutrient_topic: Vitamin D2 and D3 research collection; topical membership is not evidence of a direct dietary effect. plain_language: Offering this test-and-supplement strategy did not reduce confirmed respiratory infections. organism: Homo sapiens tissue_or_cell_type: Clinical respiratory outcomes experimental_model: CORONAVIT pragmatic randomized open-label offer-to-test-and-treat trial; 6200UKadults≥ 16 limitations: Open-label strategy trial; receipt, outside supplementation and pandemic context limit inference about specific cellular mechanisms or all dosing regimens. exposure: Offer 800 or 3200 IU/day vitamin D for 6 months if 25(OH)D<75 nmol/L versus no offer; 2674 of 3100 offered received supplements. cross_nutrient: false [jolliffe2022] Effect of a test-and-treat approach to vitamin D supplementation on risk of all cause acute respiratory tract infection and covid-19: phase 3 randomised controlled trial (CORONAVIT). (2022). https://pubmed.ncbi.nlm.nih.gov/36215226/ DOI: 10.1136/bmj-2022-071230
Complete structured claim and evidence
The events it takes part in
A mechanism often involves more than two components. These are the full events, with every participant and its role.
Situations it appears in
Low-supply and faulty-machinery situations recorded in the chapters where this component plays a part.
In the sources
Preserved passages that mention this component, quoted exactly. Open one to read it in context.
Open hypotheses
Proposed ideas that involve this component. They are labeled as hypotheses and do not change any recorded statement.
This is a research prototype built from draft material. It is not medical advice, and its statements still await verification against the original studies.