{"id":"a158e2c7-13c2-54ed-a4ab-360393872f12","stable_key":"1deb434a-3547-51a0-a038-87b1ce79ec38:vd-coronavit-ari","predicate":"does-not-significantly-reduce","statement":"At least one confirmed respiratory infection occurred in 4.6% of no-offer, 5.7% of lower-dose-offer and 5.0% of higher-dose-offer participants; ORs 1.26 (95% CI0.96–1.66) and 1.09 (0.82–1.46).","claim_class":"observational","status":"source_derived_draft","evidence_grade":"ungraded","direction":"neutral","is_public":true,"mechanism_event_id":"24ce5d16-f6a9-5019-9529-64593ae2bb1e","mechanism_event_label":"Offering this test-and-supplement strategy did not reduce confirmed respiratory infections.","subject":{"id":"43081f5e-3475-5969-b098-03e1b36126ac","slug":"vitamin-d-test-and-treat-offer","display_name":"Vitamin D testing and conditional supplementation offer","entity_type_key":"cellular_process"},"object":{"id":"5a0c5c87-927b-576d-993a-9a9f50b5af80","slug":"acute-respiratory-infection-incidence","display_name":"Acute respiratory tract infection incidence","entity_type_key":"cellular_process"},"evidence_count":1,"mechanism_event":{"id":"24ce5d16-f6a9-5019-9529-64593ae2bb1e","stable_key":"1deb434a-3547-51a0-a038-87b1ce79ec38:vd-coronavit-ari-event","event_type":"observed_intervention","label":"Offering this test-and-supplement strategy did not reduce confirmed respiratory infections.","description":"At least one confirmed respiratory infection occurred in 4.6% of no-offer, 5.7% of lower-dose-offer and 5.0% of higher-dose-offer participants; ORs 1.26 (95% CI0.96–1.66) and 1.09 (0.82–1.46).","status":"provisional","compartment":null,"participants":[{"entity":{"id":"43081f5e-3475-5969-b098-03e1b36126ac","slug":"vitamin-d-test-and-treat-offer","display_name":"Vitamin D testing and conditional supplementation offer","entity_type_key":"cellular_process"},"role":"subject","stoichiometry":null,"state_label":"","sequence_order":0,"notes":""},{"entity":{"id":"5a0c5c87-927b-576d-993a-9a9f50b5af80","slug":"acute-respiratory-infection-incidence","display_name":"Acute respiratory tract infection incidence","entity_type_key":"cellular_process"},"role":"target","stoichiometry":null,"state_label":"","sequence_order":1,"notes":""}]},"contexts":[{"dimension":"cross_nutrient","value_text":"false","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"experimental_model","value_text":"CORONAVIT pragmatic randomized open-label offer-to-test-and-treat trial; 6200UKadults≥ 16","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"exposure","value_text":"Offer 800 or 3200 IU/day vitamin D for 6 months if 25(OH)D<75 nmol/L versus no offer; 2674 of 3100 offered received supplements.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"limitations","value_text":"Open-label strategy trial; receipt, outside supplementation and pandemic context limit inference about specific cellular mechanisms or all dosing regimens.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"nutrient_topic","value_text":"Vitamin D2 and D3 research collection; topical membership is not evidence of a direct dietary effect.","comparator":null,"unit":null,"notes":"","entity":{"slug":"vitamin-d","display_name":"Vitamin D2 and D3","entity_type_key":"chemical_species"}},{"dimension":"organism","value_text":"Homo sapiens","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"plain_language","value_text":"Offering this test-and-supplement strategy did not reduce confirmed respiratory infections.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"primary_references","value_text":"[jolliffe2022] Effect of a test-and-treat approach to vitamin D supplementation on risk of all cause acute respiratory tract infection and covid-19: phase 3 randomised controlled trial (CORONAVIT). (2022). https://pubmed.ncbi.nlm.nih.gov/36215226/ DOI: 10.1136/bmj-2022-071230","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"tissue_or_cell_type","value_text":"Clinical respiratory outcomes","comparator":null,"unit":null,"notes":"","entity":null}],"evidence":[{"id":"a35155ff-cd26-5a40-ba7a-5da35598820c","evidence_kind":"source_excerpt","locator":"Lines 1652-1663","start_line":1652,"end_line":1663,"excerpt":"### vd-coronavit-ari\nAt least one confirmed respiratory infection occurred in 4.6% of no-offer, 5.7% of lower-dose-offer and 5.0% of higher-dose-offer participants; ORs 1.26 (95% CI0.96–1.66) and 1.09 (0.82–1.46).\nCondition category: normal\nnutrient_topic: Vitamin D2 and D3 research collection; topical membership is not evidence of a direct dietary effect.\nplain_language: Offering this test-and-supplement strategy did not reduce confirmed respiratory infections.\norganism: Homo sapiens\ntissue_or_cell_type: Clinical respiratory outcomes\nexperimental_model: CORONAVIT pragmatic randomized open-label offer-to-test-and-treat trial; 6200UKadults≥ 16\nlimitations: Open-label strategy trial; receipt, outside supplementation and pandemic context limit inference about specific cellular mechanisms or all dosing regimens.\nexposure: Offer 800 or 3200 IU/day vitamin D for 6 months if 25(OH)D<75 nmol/L versus no offer; 2674 of 3100 offered received supplements.\ncross_nutrient: false\n[jolliffe2022] Effect of a test-and-treat approach to vitamin D supplementation on risk of all cause acute respiratory tract infection and covid-19: phase 3 randomised controlled trial (CORONAVIT). (2022). https://pubmed.ncbi.nlm.nih.gov/36215226/ DOI: 10.1136/bmj-2022-071230","model_system":"CORONAVIT pragmatic randomized open-label offer-to-test-and-treat trial; 6200UKadults≥ 16","directness":"author_interpretation","verification_status":"source_derived_draft","notes":"Exact curation-document quotation, not publisher quotation. Study references: [jolliffe2022] Effect of a test-and-treat approach to vitamin D supplementation on risk of all cause acute respiratory tract infection and covid-19: phase 3 randomised controlled trial (CORONAVIT). (2022). https://pubmed.ncbi.nlm.nih.gov/36215226/ DOI: 10.1136/bmj-2022-071230","relationship":"supports","weight":1.0,"link_notes":"","source":{"id":"c95c763c-5b31-5b3f-a2f8-2dfe5ef0d3ca","stable_key":"import-1deb434a-3547-51a0-a038-87b1ce79ec38","title":"Vitamin D2 and D3: mechanisms, deficiency and nutrient interactions (2026-09-17)","document_type":"imported_text","citation_label":"AI-assisted literature curation; primary study URLs and scope retained in the document and extraction. Not publisher full text.","file_path":"","sha256":"51004bf0d78db6146b8f198b0688a3cc7d4ea9822415a9c034f4c8790fb4e38b","revision_id":"d52ff207-a311-5f24-96f4-462838792db5","review_status":"unverified_draft","notes":""}}],"relations":[],"conflicts":[],"corrections":[],"research":null}