Component
Plasma 25-hydroxyvitamin D2 tracer half-life
Study-defined Plasma 25-hydroxyvitamin D2 tracer half-life. Read each linked record for species, exposure and endpoint.
2 recorded relationships. Experimental role, claim status and evidence remain attached to each record.
How nutrients influence it
Every nutrient with a recorded effect on this component, credited to the nutrient that acted rather than the chapter that recorded it. Open a nutrient to see the findings and the conditions they were measured under.
Other things that act on it
Enzymes, hormones, genes, and other components with a recorded effect. These are not nutrients, so they do not count toward the arrows above. Each finding names the chapter that recorded it.
How nutrients reach it in more than one step
Chains of two or more recorded steps that end here, grouped by the nutrient they start from. Each step is a separate finding, so a chain is a route a mechanism could take, not proof that it does.
Tracing routes…
What it does
Every recorded relationship this component is part of, grouped by its role. Plain wording comes first; the technical statement follows.
What acts on it
Across both countries, mean tracer half-life was 13.9 days for 25(OH)D2 versus 15.1 days for 25(OH)D3 (P=0.001); the difference was significant in Gambians but not the UK subgroup.
Experimental context and source evidence
- cross_nutrient
- false
- experimental_model
- Oral deuterated 25(OH)D2 and 25(OH)D3 tracer study; 18 Gambian and 18 UK healthy men
- exposure
- Oral deuterated 25(OH)D2 and 25(OH)D3, 40 nmol each; sampling 33 days.
- limitations
- Measured metabolites rather than parent supplements; country subgroup and DBP associations do not provide a universal whole-body storage half-life.
- nutrient_topic
- Vitamin D2 and D3 research collection; topical membership is not evidence of a direct dietary effect. · Vitamin D2 and D3
- organism
- Homo sapiens
- plain_language
- The circulating D2-derived metabolite cleared somewhat faster overall, with variation between groups.
- primary_references
- [jones2014] 25(OH)D2 half-life is shorter than 25(OH)D3 half-life and is influenced by DBP concentration and genotype. (2014). https://pubmed.ncbi.nlm.nih.gov/24885631/ DOI: 10.1210/jc.2014-1714
- tissue_or_cell_type
- Human circulating measurements
Vitamin D2 and D3: mechanisms, deficiency and nutrient interactions (2026-09-17) · lines 1379–1390
AI-assisted literature curation; primary study URLs and scope retained in the document and extraction. Not publisher full text. · supports · Oral deuterated 25(OH)D2 and 25(OH)D3 tracer study; 18 Gambian and 18 UK healthy men · source_derived_draft · unverified_draft
### vd-jones-half-life Across both countries, mean tracer half-life was 13.9 days for 25(OH)D2 versus 15.1 days for 25(OH)D3 (P=0.001); the difference was significant in Gambians but not the UK subgroup. Condition category: normal nutrient_topic: Vitamin D2 and D3 research collection; topical membership is not evidence of a direct dietary effect. plain_language: The circulating D2-derived metabolite cleared somewhat faster overall, with variation between groups. organism: Homo sapiens tissue_or_cell_type: Human circulating measurements experimental_model: Oral deuterated 25(OH)D2 and 25(OH)D3 tracer study; 18 Gambian and 18 UK healthy men limitations: Measured metabolites rather than parent supplements; country subgroup and DBP associations do not provide a universal whole-body storage half-life. exposure: Oral deuterated 25(OH)D2 and 25(OH)D3, 40 nmol each; sampling 33 days. cross_nutrient: false [jones2014] 25(OH)D2 half-life is shorter than 25(OH)D3 half-life and is influenced by DBP concentration and genotype. (2014). https://pubmed.ncbi.nlm.nih.gov/24885631/ DOI: 10.1210/jc.2014-1714
Complete structured claim and evidence
Where it participates (unsigned role)
Higher plasma DBP concentration was associated with longer 25(OH)D3 half-life in the combined model (0.04 days per 1 mg/L DBP; P=0.02); the corresponding 25(OH)D2 association was 0.03 days (P=0.03).
Experimental context and source evidence
- availability_state
- biomarker_context Imported condition classification; unverified.
- cross_nutrient
- false
- experimental_model
- Oral deuterated 25(OH)D2 and 25(OH)D3 tracer study; 18 Gambian and 18 UK healthy men
- exposure
- Oral deuterated 25(OH)D2 and 25(OH)D3, 40 nmol each; sampling 33 days.
- limitations
- Measured metabolites rather than parent supplements; country subgroup and DBP associations do not provide a universal whole-body storage half-life.
- nutrient_topic
- Vitamin D2 and D3 research collection; topical membership is not evidence of a direct dietary effect. · Vitamin D2 and D3
- organism
- Homo sapiens
- plain_language
- Carrier abundance was associated with metabolite persistence; it was not experimentally assigned.
- primary_references
- [jones2014] 25(OH)D2 half-life is shorter than 25(OH)D3 half-life and is influenced by DBP concentration and genotype. (2014). https://pubmed.ncbi.nlm.nih.gov/24885631/ DOI: 10.1210/jc.2014-1714
- tissue_or_cell_type
- Human circulating measurements
- trigger_kind
- biomarker_context Imported condition classification; unverified.
Vitamin D2 and D3: mechanisms, deficiency and nutrient interactions (2026-09-17) · lines 1392–1403
AI-assisted literature curation; primary study URLs and scope retained in the document and extraction. Not publisher full text. · supports · Oral deuterated 25(OH)D2 and 25(OH)D3 tracer study; 18 Gambian and 18 UK healthy men · source_derived_draft · unverified_draft
### vd-jones-dbp-half-life Higher plasma DBP concentration was associated with longer 25(OH)D3 half-life in the combined model (0.04 days per 1 mg/L DBP; P=0.02); the corresponding 25(OH)D2 association was 0.03 days (P=0.03). Condition category: biomarker_context nutrient_topic: Vitamin D2 and D3 research collection; topical membership is not evidence of a direct dietary effect. plain_language: Carrier abundance was associated with metabolite persistence; it was not experimentally assigned. organism: Homo sapiens tissue_or_cell_type: Human circulating measurements experimental_model: Oral deuterated 25(OH)D2 and 25(OH)D3 tracer study; 18 Gambian and 18 UK healthy men limitations: Measured metabolites rather than parent supplements; country subgroup and DBP associations do not provide a universal whole-body storage half-life. exposure: Oral deuterated 25(OH)D2 and 25(OH)D3, 40 nmol each; sampling 33 days. cross_nutrient: false [jones2014] 25(OH)D2 half-life is shorter than 25(OH)D3 half-life and is influenced by DBP concentration and genotype. (2014). https://pubmed.ncbi.nlm.nih.gov/24885631/ DOI: 10.1210/jc.2014-1714
Complete structured claim and evidence
The events it takes part in
A mechanism often involves more than two components. These are the full events, with every participant and its role.
Situations it appears in
Low-supply and faulty-machinery situations recorded in the chapters where this component plays a part.
In the sources
Preserved passages that mention this component, quoted exactly. Open one to read it in context.
Open hypotheses
Proposed ideas that involve this component. They are labeled as hypotheses and do not change any recorded statement.
This is a research prototype built from draft material. It is not medical advice, and its statements still await verification against the original studies.