{"id":"49e0bb36-baa6-5073-b2e3-c10e7fdd6050","stable_key":"1deb434a-3547-51a0-a038-87b1ce79ec38:vd-jones-dbp-half-life","predicate":"is-associated-with-longer","statement":"Higher plasma DBP concentration was associated with longer 25(OH)D3 half-life in the combined model (0.04 days per 1 mg/L DBP; P=0.02); the corresponding 25(OH)D2 association was 0.03 days (P=0.03).","claim_class":"observational","status":"source_derived_draft","evidence_grade":"ungraded","direction":"context_dependent","is_public":true,"mechanism_event_id":"e9818220-6900-5711-ab3d-0fa913852481","mechanism_event_label":"Carrier abundance was associated with metabolite persistence; it was not experimentally assigned.","subject":{"id":"753c9740-db0d-5052-8f4e-2557a7632ab8","slug":"plasma-vitamin-d-binding-protein","display_name":"Plasma vitamin D binding protein concentration","entity_type_key":"cellular_process"},"object":{"id":"549c5fa5-b852-54ed-988b-a7bccf5b3fe3","slug":"25-hydroxyvitamin-d3-plasma-half-life","display_name":"Plasma 25-hydroxyvitamin D3 tracer half-life","entity_type_key":"cellular_process"},"evidence_count":1,"mechanism_event":{"id":"e9818220-6900-5711-ab3d-0fa913852481","stable_key":"1deb434a-3547-51a0-a038-87b1ce79ec38:vd-jones-dbp-half-life-event","event_type":"observed_intervention","label":"Carrier abundance was associated with metabolite persistence; it was not experimentally assigned.","description":"Higher plasma DBP concentration was associated with longer 25(OH)D3 half-life in the combined model (0.04 days per 1 mg/L DBP; P=0.02); the corresponding 25(OH)D2 association was 0.03 days (P=0.03).","status":"provisional","compartment":null,"participants":[{"entity":{"id":"6ad7484b-5024-5725-bb99-5651d6a617e9","slug":"25-hydroxyvitamin-d2-plasma-half-life","display_name":"Plasma 25-hydroxyvitamin D2 tracer half-life","entity_type_key":"cellular_process"},"role":"related-endpoint","stoichiometry":null,"state_label":"","sequence_order":0,"notes":""},{"entity":{"id":"ac7c6f66-5489-5d3a-899f-b1f4f08a5f0a","slug":"gc","display_name":"Human vitamin D-binding protein / GC","entity_type_key":"protein"},"role":"measured-carrier","stoichiometry":null,"state_label":"","sequence_order":1,"notes":""},{"entity":{"id":"753c9740-db0d-5052-8f4e-2557a7632ab8","slug":"plasma-vitamin-d-binding-protein","display_name":"Plasma vitamin D binding protein concentration","entity_type_key":"cellular_process"},"role":"subject","stoichiometry":null,"state_label":"","sequence_order":2,"notes":""},{"entity":{"id":"549c5fa5-b852-54ed-988b-a7bccf5b3fe3","slug":"25-hydroxyvitamin-d3-plasma-half-life","display_name":"Plasma 25-hydroxyvitamin D3 tracer half-life","entity_type_key":"cellular_process"},"role":"target","stoichiometry":null,"state_label":"","sequence_order":3,"notes":""}]},"contexts":[{"dimension":"availability_state","value_text":"biomarker_context","comparator":null,"unit":null,"notes":"Imported condition classification; unverified.","entity":null},{"dimension":"cross_nutrient","value_text":"false","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"experimental_model","value_text":"Oral deuterated 25(OH)D2 and 25(OH)D3 tracer study; 18 Gambian and 18 UK healthy men","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"exposure","value_text":"Oral deuterated 25(OH)D2 and 25(OH)D3, 40 nmol each; sampling 33 days.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"limitations","value_text":"Measured metabolites rather than parent supplements; country subgroup and DBP associations do not provide a universal whole-body storage half-life.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"nutrient_topic","value_text":"Vitamin D2 and D3 research collection; topical membership is not evidence of a direct dietary effect.","comparator":null,"unit":null,"notes":"","entity":{"slug":"vitamin-d","display_name":"Vitamin D2 and D3","entity_type_key":"chemical_species"}},{"dimension":"organism","value_text":"Homo sapiens","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"plain_language","value_text":"Carrier abundance was associated with metabolite persistence; it was not experimentally assigned.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"primary_references","value_text":"[jones2014] 25(OH)D2 half-life is shorter than 25(OH)D3 half-life and is influenced by DBP concentration and genotype. (2014). https://pubmed.ncbi.nlm.nih.gov/24885631/ DOI: 10.1210/jc.2014-1714","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"tissue_or_cell_type","value_text":"Human circulating measurements","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"trigger_kind","value_text":"biomarker_context","comparator":null,"unit":null,"notes":"Imported condition classification; unverified.","entity":null}],"evidence":[{"id":"649ce8f6-2ca6-5e5f-b80e-8f7c49d7d6cd","evidence_kind":"source_excerpt","locator":"Lines 1392-1403","start_line":1392,"end_line":1403,"excerpt":"### vd-jones-dbp-half-life\nHigher plasma DBP concentration was associated with longer 25(OH)D3 half-life in the combined model (0.04 days per 1 mg/L DBP; P=0.02); the corresponding 25(OH)D2 association was 0.03 days (P=0.03).\nCondition category: biomarker_context\nnutrient_topic: Vitamin D2 and D3 research collection; topical membership is not evidence of a direct dietary effect.\nplain_language: Carrier abundance was associated with metabolite persistence; it was not experimentally assigned.\norganism: Homo sapiens\ntissue_or_cell_type: Human circulating measurements\nexperimental_model: Oral deuterated 25(OH)D2 and 25(OH)D3 tracer study; 18 Gambian and 18 UK healthy men\nlimitations: Measured metabolites rather than parent supplements; country subgroup and DBP associations do not provide a universal whole-body storage half-life.\nexposure: Oral deuterated 25(OH)D2 and 25(OH)D3, 40 nmol each; sampling 33 days.\ncross_nutrient: false\n[jones2014] 25(OH)D2 half-life is shorter than 25(OH)D3 half-life and is influenced by DBP concentration and genotype. (2014). https://pubmed.ncbi.nlm.nih.gov/24885631/ DOI: 10.1210/jc.2014-1714","model_system":"Oral deuterated 25(OH)D2 and 25(OH)D3 tracer study; 18 Gambian and 18 UK healthy men","directness":"author_interpretation","verification_status":"source_derived_draft","notes":"Exact curation-document quotation, not publisher quotation. Study references: [jones2014] 25(OH)D2 half-life is shorter than 25(OH)D3 half-life and is influenced by DBP concentration and genotype. (2014). https://pubmed.ncbi.nlm.nih.gov/24885631/ DOI: 10.1210/jc.2014-1714","relationship":"supports","weight":1.0,"link_notes":"","source":{"id":"c95c763c-5b31-5b3f-a2f8-2dfe5ef0d3ca","stable_key":"import-1deb434a-3547-51a0-a038-87b1ce79ec38","title":"Vitamin D2 and D3: mechanisms, deficiency and nutrient interactions (2026-09-17)","document_type":"imported_text","citation_label":"AI-assisted literature curation; primary study URLs and scope retained in the document and extraction. 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