Component
Hemoglobin in zebrafish Slc25a38-deficiency model
Context-specific entity; species, compartment and exposure are stated on each claim.
2 recorded relationships. Experimental role, claim status and evidence remain attached to each record.
How nutrients influence it
Every nutrient with a recorded effect on this component, credited to the nutrient that acted rather than the chapter that recorded it. Open a nutrient to see the findings and the conditions they were measured under.
Other things that act on it
Enzymes, hormones, genes, and other components with a recorded effect. These are not nutrients, so they do not count toward the arrows above. Each finding names the chapter that recorded it.
How nutrients reach it in more than one step
Chains of two or more recorded steps that end here, grouped by the nutrient they start from. Each step is a separate finding, so a chain is a route a mechanism could take, not proof that it does.
Tracing routes…
What it does
Every recorded relationship this component is part of, grouped by its role. Plain wording comes first; the technical statement follows.
What acts on it
Glycine alone did not restore hemoglobin in the zebrafish Slc25a38 congenital-sideroblastic-anemia model.
Experimental context and source evidence
- availability_state
- machinery_impairment Imported condition classification; unverified.
- evidence_access
- Primary full text
- experimental_model
- Zebrafish Slc25a38-deficiency model with supplementation.
- limitations
- Species, folate synthesis and exposure differ from yeast; a context difference is not a fabricated contradiction.
- nutrient_topic
- Glycine collection; species, compartment, exposure, co-substrates and manipulation remain explicit. · Glycine
- plain_language
- The single-ingredient rescue did not transfer from yeast to this animal model.
- primary_references
- Glycine and Folate Ameliorate Models of Congenital Sideroblastic Anemia. · 2016 · https://pubmed.ncbi.nlm.nih.gov/26821380/ · DOI 10.1371/journal.pgen.1005783
- trigger_kind
- machinery_impairment Imported condition classification; unverified.
Glycine: supply, one-carbon allocation, receptors and cross-nutrient mechanisms (2026-09-19) · lines 98–104
AI-assisted research curation; primary references, access levels and experimental limitations individually identified. Not publisher full text. · supports · Zebrafish Slc25a38-deficiency model with supplementation. · source_derived_draft · unverified_draft
## glycine-fish-glycine-alone The single-ingredient rescue did not transfer from yeast to this animal model. Glycine alone did not restore hemoglobin in the zebrafish Slc25a38 congenital-sideroblastic-anemia model. Model: Zebrafish Slc25a38-deficiency model with supplementation. Limitations: Species, folate synthesis and exposure differ from yeast; a context difference is not a fabricated contradiction. Evidence access: Primary full text Glycine and Folate Ameliorate Models of Congenital Sideroblastic Anemia. · 2016 · https://pubmed.ncbi.nlm.nih.gov/26821380/ · DOI 10.1371/journal.pgen.1005783
Complete structured claim and evidenceAdding folate with glycine restored hemoglobin in the tested zebrafish Slc25a38-deficiency model.
Experimental context and source evidence
- availability_state
- machinery_impairment Imported condition classification; unverified.
- evidence_access
- Primary full text
- experimental_model
- Zebrafish supplementation experiment.
- limitations
- Combination rescue is recorded without claiming clinical efficacy or statistical synergy in humans.
- nutrient_topic
- Glycine collection; species, compartment, exposure, co-substrates and manipulation remain explicit. · Glycine
- plain_language
- A second nutrient changed the response to the first in this model.
- primary_references
- Glycine and Folate Ameliorate Models of Congenital Sideroblastic Anemia. · 2016 · https://pubmed.ncbi.nlm.nih.gov/26821380/ · DOI 10.1371/journal.pgen.1005783
- trigger_kind
- machinery_impairment Imported condition classification; unverified.
Glycine: supply, one-carbon allocation, receptors and cross-nutrient mechanisms (2026-09-19) · lines 106–112
AI-assisted research curation; primary references, access levels and experimental limitations individually identified. Not publisher full text. · supports · Zebrafish supplementation experiment. · source_derived_draft · unverified_draft
## glycine-fish-glycine-folate A second nutrient changed the response to the first in this model. Adding folate with glycine restored hemoglobin in the tested zebrafish Slc25a38-deficiency model. Model: Zebrafish supplementation experiment. Limitations: Combination rescue is recorded without claiming clinical efficacy or statistical synergy in humans. Evidence access: Primary full text Glycine and Folate Ameliorate Models of Congenital Sideroblastic Anemia. · 2016 · https://pubmed.ncbi.nlm.nih.gov/26821380/ · DOI 10.1371/journal.pgen.1005783
Complete structured claim and evidence
The events it takes part in
A mechanism often involves more than two components. These are the full events, with every participant and its role.
Situations it appears in
Low-supply and faulty-machinery situations recorded in the chapters where this component plays a part.
In the sources
Preserved passages that mention this component, quoted exactly. Open one to read it in context.
Open hypotheses
Proposed ideas that involve this component. They are labeled as hypotheses and do not change any recorded statement.
This is a research prototype built from draft material. It is not medical advice, and its statements still await verification against the original studies.