Component
Saccharomyces cerevisiae glucose-6-phosphate dehydrogenase / Zwf1
Saccharomyces cerevisiae glucose-6-phosphate dehydrogenase / Zwf1. Interpret through the linked study species, preparation, exposure and measured endpoint.
1 recorded relationships. Experimental role, claim status and evidence remain attached to each record.
How nutrients influence it
Every nutrient with a recorded effect on this component, credited to the nutrient that acted rather than the chapter that recorded it. Open a nutrient to see the findings and the conditions they were measured under.
Other things that act on it
Enzymes, hormones, genes, and other components with a recorded effect. These are not nutrients, so they do not count toward the arrows above. Each finding names the chapter that recorded it.
How nutrients reach it in more than one step
Chains of two or more recorded steps that end here, grouped by the nutrient they start from. Each step is a separate finding, so a chain is a route a mechanism could take, not proof that it does.
Tracing routes…
What it does
Every recorded relationship this component is part of, grouped by its role. Plain wording comes first; the technical statement follows.
What it acts on
Loss of yeast-zwf1 increased susceptibility in the allicin arm of the yeast chemical-genetic comparison.
Experimental context and source evidence
- availability_state
- machinery_impairment Imported condition classification; unverified.
- evidence_access
- Primary full text available; selected claim-relevant methods, results, tables/figures and limitations reviewed. Supplemental proteome and all secondary findings are not exhaustively extracted.
- experimental_condition
- Wild-type yeast at the same allicin exposure present · Allicin Condition belongs to the full experimental contrast; do not separate a joint intervention.
- experimental_condition
- Wild-type yeast at the same allicin exposure deleted · Saccharomyces cerevisiae glucose-6-phosphate dehydrogenase / Zwf1 Condition belongs to the full experimental contrast; do not separate a joint intervention.
- experimental_contrast
- {"intervention": "yeast-zwf1 deletion with allicin", "comparator": "Wild-type yeast at the same allicin exposure", "endpoint": "Loss of yeast-zwf1 increased susceptibility in the allicin arm of the yeast chemical-genetic comparison.", "effect_direction": "decrease", "combination": "joint", "conditions": [{"entity_slug": "yeast-zwf1", "state": "deleted"}, {"entity_slug": "allicin", "state": "present"}]} Explicit extracted experimental comparison; source-derived draft.
- experimental_model
- Saccharomyces cerevisiae; separate gene deletions and allicin exposures compared with an analogue; Figure 3.
- interpretation_status
- Source-derived extraction of a fact-checked reference; access is explicit, not independent raw-data verification.
- limitations
- Keep dose and compound distinctions: analogue effects cannot substitute for allicin. Not a human nutrient-deficiency phenotype.
- plain_language
- Loss of yeast-zwf1 increased susceptibility in the allicin arm of the yeast chemical-genetic comparison.
- primary_references
- The Sulfilimine Analogue of Allicin, <i>S</i>-Allyl-<i>S</i>-(<i>S</i>-allyl)-<i>N</i>-Cyanosulfilimine, Is Antimicrobial and Reacts with Glutathione. | 2020 | DOI 10.3390/antiox9111086 | PMID 33158268 | https://pubmed.ncbi.nlm.nih.gov/33158268/ | https://pmc.ncbi.nlm.nih.gov/articles/PMC7694261/ | https://doi.org/10.3390/antiox9111086
- source_locator
- Reviewed reference lines 49-49; exact primary location described in quoted passage where extracted.
- trigger_kind
- machinery_impairment Imported condition classification; unverified.
Allicin: detailed mechanisms of action (reviewed 5 October 2026) · lines 49–49
Original AI-assisted review of primary studies and, where relevant, official regulatory records. Access level is retained per claim. Corrections, null results and unresolved questions remain explicit. Not publisher full text or independent replication. · supports · Saccharomyces cerevisiae; separate gene deletions and allicin exposures compared with an analogue; Figure 3. · source_derived_draft · unverified_draft
**Redox-defense impairment.** A study comparing allicin with a sulfilimine analogue included allicin-exposed Saccharomyces cerevisiae mutants. The GLR1, ZWF1, and YAP1 perturbations connect susceptibility to glutathione recycling, NADPH supply, and stress regulation; effects depended on concentration and compound. The analogue was more potent in some low-concentration comparisons, and its results must not be copied onto allicin. TRX2 loss had a much smaller effect in this system. Human B2 deficiency, G6PD deficiency, or selenium status cannot be assigned the yeast phenotype without direct evidence. [Horn 2020](https://pmc.ncbi.nlm.nih.gov/articles/PMC7694261/)
Complete structured claim and evidence
The events it takes part in
A mechanism often involves more than two components. These are the full events, with every participant and its role.
Situations it appears in
Low-supply and faulty-machinery situations recorded in the chapters where this component plays a part.
In the sources
Preserved passages that mention this component, quoted exactly. Open one to read it in context.
Open hypotheses
Proposed ideas that involve this component. They are labeled as hypotheses and do not change any recorded statement.
This is a research prototype built from draft material. It is not medical advice, and its statements still await verification against the original studies.