Component
Saccharomyces cerevisiae copper-responsive transcription factor / Mac1
Saccharomyces cerevisiae copper-responsive transcription factor / Mac1. Interpret through the linked study species, preparation, exposure and measured endpoint.
1 recorded relationships. Experimental role, claim status and evidence remain attached to each record.
How nutrients influence it
Every nutrient with a recorded effect on this component, credited to the nutrient that acted rather than the chapter that recorded it. Open a nutrient to see the findings and the conditions they were measured under.
Other things that act on it
Enzymes, hormones, genes, and other components with a recorded effect. These are not nutrients, so they do not count toward the arrows above. Each finding names the chapter that recorded it.
How nutrients reach it in more than one step
Chains of two or more recorded steps that end here, grouped by the nutrient they start from. Each step is a separate finding, so a chain is a route a mechanism could take, not proof that it does.
Tracing routes…
What it does
Every recorded relationship this component is part of, grouped by its role. Plain wording comes first; the technical statement follows.
What it acts on
Deletion of yeast-mac1 increased yeast sensitivity to allicin.
Experimental context and source evidence
- availability_state
- machinery_impairment Imported condition classification; unverified.
- evidence_access
- Primary indexed abstract reviewed; full methods, exact concentrations or species-specific attribution remain unextracted unless explicitly stated in the abstract or separately verified publisher text.
- experimental_condition
- Yeast comparator without that deletion at matched allicin exposure present · Allicin Condition belongs to the full experimental contrast; do not separate a joint intervention.
- experimental_condition
- Yeast comparator without that deletion at matched allicin exposure deleted · Saccharomyces cerevisiae copper-responsive transcription factor / Mac1 Condition belongs to the full experimental contrast; do not separate a joint intervention.
- experimental_contrast
- {"intervention": "yeast-mac1 deletion with allicin", "comparator": "Yeast comparator without that deletion at matched allicin exposure", "endpoint": "Deletion of yeast-mac1 increased yeast sensitivity to allicin.", "effect_direction": "decrease", "combination": "joint", "conditions": [{"entity_slug": "yeast-mac1", "state": "deleted"}, {"entity_slug": "allicin", "state": "present"}]} Explicit extracted experimental comparison; source-derived draft.
- experimental_model
- Saccharomyces cerevisiae deletion screen; primary abstract; exact dose and exposure duration unextracted.
- interpretation_status
- Source-derived extraction of a fact-checked reference; access is explicit, not independent raw-data verification.
- limitations
- Hypersensitivity does not prove direct binding to the deleted protein or distinguish metal uptake from metalloprotein dysfunction.
- plain_language
- Deletion of yeast-mac1 increased yeast sensitivity to allicin.
- primary_references
- A Mini HIP HOP Assay Uncovers a Central Role for Copper and Zinc in the Antifungal Mode of Action of Allicin. | 2017 | DOI 10.1021/acs.jafc.7b00250 | PMID 28421744 | https://pubmed.ncbi.nlm.nih.gov/28421744/ | https://doi.org/10.1021/acs.jafc.7b00250
- source_locator
- Reviewed reference lines 59-59; exact primary location described in quoted passage where extracted.
- trigger_kind
- machinery_impairment Imported condition classification; unverified.
Allicin: detailed mechanisms of action (reviewed 5 October 2026) · lines 59–59
Original AI-assisted review of primary studies and, where relevant, official regulatory records. Access level is retained per claim. Corrections, null results and unresolved questions remain explicit. Not publisher full text or independent replication. · supports · Saccharomyces cerevisiae deletion screen; primary abstract; exact dose and exposure duration unextracted. · source_derived_draft · unverified_draft
**Yeast metal requirements.** In a chemical-genetic screen of Saccharomyces cerevisiae, loss of CTR1, MAC1, or ZAP1 increased sensitivity to allicin; copper or zinc additions rescued the relevant sensitized phenotypes. This supports involvement of metal acquisition or metalloprotein function but does not discriminate those alternatives. It is not direct proof that allicin binds each protein, chelates all intracellular copper, or causes human mineral deficiency. Exact supplementation concentrations and all strain-specific contrasts remain unextracted from the accessible abstract. [Prescott and Panaretou 2017](https://pubmed.ncbi.nlm.nih.gov/28421744/)
Complete structured claim and evidence
The events it takes part in
A mechanism often involves more than two components. These are the full events, with every participant and its role.
Situations it appears in
Low-supply and faulty-machinery situations recorded in the chapters where this component plays a part.
In the sources
Preserved passages that mention this component, quoted exactly. Open one to read it in context.
Open hypotheses
Proposed ideas that involve this component. They are labeled as hypotheses and do not change any recorded statement.
This is a research prototype built from draft material. It is not medical advice, and its statements still await verification against the original studies.