Component
Human YAP1
Context-specific entity; species, compartment and exposure are stated on each claim.
1 recorded relationships. Experimental role, claim status and evidence remain attached to each record.
How nutrients influence it
Every nutrient with a recorded effect on this component, credited to the nutrient that acted rather than the chapter that recorded it. Open a nutrient to see the findings and the conditions they were measured under.
Other things that act on it
Enzymes, hormones, genes, and other components with a recorded effect. These are not nutrients, so they do not count toward the arrows above. Each finding names the chapter that recorded it.
How nutrients reach it in more than one step
Chains of two or more recorded steps that end here, grouped by the nutrient they start from. Each step is a separate finding, so a chain is a route a mechanism could take, not proof that it does.
Tracing routes…
What it does
Every recorded relationship this component is part of, grouped by its role. Plain wording comes first; the technical statement follows.
Where it participates (unsigned role)
Human AARS1 used lactate and ATP for protein lactylation; the study identified YAP K90 and TEAD1 K108 modification and activation in gastric cancer models.
Experimental context and source evidence
- evidence_access
- Primary full text
- experimental_model
- Recombinant enzyme and human gastric cancer cell experiments.
- limitations
- This is an enzyme connection, not proof that adding L-alanine promotes or inhibits lactylation. Beta-alanine inhibitor findings must not be transferred to L-alanine.
- nutrient_topic
- L-Alanine collection; species, compartment, exposure, co-substrates and manipulation remain explicit. · L-Alanine
- plain_language
- The alanine-handling enzyme also has a separate lactate-driven signaling activity.
- primary_references
- The alanyl-tRNA synthetase AARS1 moonlights as a lactyltransferase to promote YAP signaling in gastric cancer. · 2024 · https://pubmed.ncbi.nlm.nih.gov/38512451/ · DOI 10.1172/JCI174587
L-Alanine: carbon, nitrogen, protein synthesis and cross-nutrient mechanisms (2026-09-19) · lines 72–78
AI-assisted research curation; primary references, access levels and experimental limitations individually identified. Not publisher full text. · supports · Recombinant enzyme and human gastric cancer cell experiments. · source_derived_draft · unverified_draft
## alanine-aars-lactylation The alanine-handling enzyme also has a separate lactate-driven signaling activity. Human AARS1 used lactate and ATP for protein lactylation; the study identified YAP K90 and TEAD1 K108 modification and activation in gastric cancer models. Model: Recombinant enzyme and human gastric cancer cell experiments. Limitations: This is an enzyme connection, not proof that adding L-alanine promotes or inhibits lactylation. Beta-alanine inhibitor findings must not be transferred to L-alanine. Evidence access: Primary full text The alanyl-tRNA synthetase AARS1 moonlights as a lactyltransferase to promote YAP signaling in gastric cancer. · 2024 · https://pubmed.ncbi.nlm.nih.gov/38512451/ · DOI 10.1172/JCI174587
Complete structured claim and evidence
The events it takes part in
A mechanism often involves more than two components. These are the full events, with every participant and its role.
Situations it appears in
Low-supply and faulty-machinery situations recorded in the chapters where this component plays a part.
In the sources
Preserved passages that mention this component, quoted exactly. Open one to read it in context.
Open hypotheses
Proposed ideas that involve this component. They are labeled as hypotheses and do not change any recorded statement.
This is a research prototype built from draft material. It is not medical advice, and its statements still await verification against the original studies.