Cure rate and egg reduction rate in treated infection: molecular mechanisms & dependencies

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What it does

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What acts on it

In 958 children randomly allocated to seven treatment groups, the efficacy of single-dose 300 milligrams of polymorph A was not different from the placebo control at the 0.05 level in both hookworm and Trichuris infections, while the egg reduction and cure rates of 300 and 500 milligrams of polymorph C were similar to each other though inferior to the standard 100 milligrams twice daily for three days.
Mebendazole polymorph A → Cure rate and egg reduction rate in treated infection source_derived_draftungraded
Experimental context and source evidence
availability_state
biomarker_context Imported condition classification; unverified.
evidence_span
{"source_cache": "artifacts/mebendazole-research/7939946.abstract.txt", "locator": "Indexed abstract; zero-based, end-exclusive Unicode character offsets", "file_sha256": "972b8bb36b68b1f40fba5f7bdb38668e9d1c40cba27ddeb19db16a3bcf29053d", "start_char": 0, "end_char": 698, "text_sha256": "972b8bb36b68b1f40fba5f7bdb38668e9d1c40cba27ddeb19db16a3bcf29053d"}
experimental_model
Randomised seven-arm trial in 958 schoolchildren in Southern Thailand
exposure
Single doses of 300 milligrams polymorph A, 300 and 500 milligrams polymorph C, against placebo and against 100 milligrams polymorph C twice daily for three days
limitations
The only human record here that varies the crystal form, with a placebo arm. It is a single-dose comparison and does not follow reinfection.
nutrient_topic
Mebendazole research collection; topical membership is not evidence of a direct clinical effect, and mebendazole is recorded separately from albendazole, from the benzimidazole class and from its own crystal forms. · Mebendazole
organism
Human
plain_language
In children, a full dose of the wrong crystal form worked no better than a sugar pill.
primary_references
[mbz-p7939946] Efficacy of single-dose mebendazole, polymorphic forms A and C, in the treatment of hookworm and Trichuris infections. (1993). https://pubmed.ncbi.nlm.nih.gov/7939946/
tissue_or_cell_type
Hookworm and Trichuris infection
trigger_kind
biomarker_context Imported condition classification; unverified.
Mebendazole: the tubulin it binds, why that is selective, the crystal form that decides whether any of it works, and the off-target that became an oncology programme (2026-09-22) · lines 368–379
AI-assisted literature curation; primary study URLs and scope retained in the document and extraction. Not publisher full text. · supports · Randomised seven-arm trial in 958 schoolchildren in Southern Thailand · source_derived_draft · unverified_draft
### mbz-polymorph-a-equals-placebo In 958 children randomly allocated to seven treatment groups, the efficacy of single-dose 300 milligrams of polymorph A was not different from the placebo control at the 0.05 level in both hookworm and Trichuris infections, while the egg reduction and cure rates of 300 and 500 milligrams of polymorph C were similar to each other though inferior to the standard 100 milligrams twice daily for three days. Condition category: biomarker_context nutrient_topic: Mebendazole research collection; topical membership is not evidence of a direct clinical effect, and mebendazole is recorded separately from albendazole, from the benzimidazole class and from its own crystal forms. plain_language: In children, a full dose of the wrong crystal form worked no better than a sugar pill. organism: Human tissue_or_cell_type: Hookworm and Trichuris infection experimental_model: Randomised seven-arm trial in 958 schoolchildren in Southern Thailand limitations: The only human record here that varies the crystal form, with a placebo arm. It is a single-dose comparison and does not follow reinfection. exposure: Single doses of 300 milligrams polymorph A, 300 and 500 milligrams polymorph C, against placebo and against 100 milligrams polymorph C twice daily for three days evidence_span: {"source_cache": "artifacts/mebendazole-research/7939946.abstract.txt", "locator": "Indexed abstract; zero-based, end-exclusive Unicode character offsets", "file_sha256": "972b8bb36b68b1f40fba5f7bdb38668e9d1c40cba27ddeb19db16a3bcf29053d", "start_char": 0, "end_char": 698, "text_sha256": "972b8bb36b68b1f40fba5f7bdb38668e9d1c40cba27ddeb19db16a3bcf29053d"} [mbz-p7939946] Efficacy of single-dose mebendazole, polymorphic forms A and C, in the treatment of hookworm and Trichuris infections. (1993). https://pubmed.ncbi.nlm.nih.gov/7939946/
Complete structured claim and evidence
Testing the biological activity of the three polymorphic forms of mebendazole called A, B and C by median lethal dose in mice after oral and intraperitoneal administration and by anthelmintic effect against the enteral and parenteral phases of Trichinella spiralis, the polymorphic form A was the least toxic and the least effective, and use of polymorph C was judged advisable for oral treatment given its lower toxicity than form B and similar anthelmintic effect.
Mebendazole polymorph A → Cure rate and egg reduction rate in treated infection source_derived_draftungraded
Experimental context and source evidence
evidence_span
{"source_cache": "artifacts/mebendazole-research/3608627.abstract.txt", "locator": "Indexed abstract; zero-based, end-exclusive Unicode character offsets", "file_sha256": "cf4b94d7b266abf376ded706272be7f440f6f46b82db5ee9c36d2c34af6e8825", "start_char": 0, "end_char": 608, "text_sha256": "cf4b94d7b266abf376ded706272be7f440f6f46b82db5ee9c36d2c34af6e8825"}
experimental_model
Median lethal dose and anthelmintic efficacy of three mebendazole polymorphs in mice
exposure
Polymorphs A, B and C given orally and intraperitoneally, against enteral and parenteral phases of infection
limitations
Tests toxicity and efficacy of the three solid forms in the same animals. Numerical values for the median lethal doses are not given in the abstract and are not assumed here.
nutrient_topic
Mebendazole research collection; topical membership is not evidence of a direct clinical effect, and mebendazole is recorded separately from albendazole, from the benzimidazole class and from its own crystal forms. · Mebendazole
organism
Mouse
plain_language
One crystal form of the same molecule barely poisons the mouse and barely touches the worm.
primary_references
[mbz-p3608627] Experimental chemotherapy and toxicity in mice of three mebendazole polymorphic forms. (1987). https://pubmed.ncbi.nlm.nih.gov/3608627/ DOI: 10.1159/000238506
tissue_or_cell_type
Whole body and Trichinella spiralis infection
Mebendazole: the tubulin it binds, why that is selective, the crystal form that decides whether any of it works, and the off-target that became an oncology programme (2026-09-22) · lines 355–366
AI-assisted literature curation; primary study URLs and scope retained in the document and extraction. Not publisher full text. · supports · Median lethal dose and anthelmintic efficacy of three mebendazole polymorphs in mice · source_derived_draft · unverified_draft
### mbz-polymorph-a-is-inert Testing the biological activity of the three polymorphic forms of mebendazole called A, B and C by median lethal dose in mice after oral and intraperitoneal administration and by anthelmintic effect against the enteral and parenteral phases of Trichinella spiralis, the polymorphic form A was the least toxic and the least effective, and use of polymorph C was judged advisable for oral treatment given its lower toxicity than form B and similar anthelmintic effect. Condition category: normal nutrient_topic: Mebendazole research collection; topical membership is not evidence of a direct clinical effect, and mebendazole is recorded separately from albendazole, from the benzimidazole class and from its own crystal forms. plain_language: One crystal form of the same molecule barely poisons the mouse and barely touches the worm. organism: Mouse tissue_or_cell_type: Whole body and Trichinella spiralis infection experimental_model: Median lethal dose and anthelmintic efficacy of three mebendazole polymorphs in mice limitations: Tests toxicity and efficacy of the three solid forms in the same animals. Numerical values for the median lethal doses are not given in the abstract and are not assumed here. exposure: Polymorphs A, B and C given orally and intraperitoneally, against enteral and parenteral phases of infection evidence_span: {"source_cache": "artifacts/mebendazole-research/3608627.abstract.txt", "locator": "Indexed abstract; zero-based, end-exclusive Unicode character offsets", "file_sha256": "cf4b94d7b266abf376ded706272be7f440f6f46b82db5ee9c36d2c34af6e8825", "start_char": 0, "end_char": 608, "text_sha256": "cf4b94d7b266abf376ded706272be7f440f6f46b82db5ee9c36d2c34af6e8825"} [mbz-p3608627] Experimental chemotherapy and toxicity in mice of three mebendazole polymorphic forms. (1987). https://pubmed.ncbi.nlm.nih.gov/3608627/ DOI: 10.1159/000238506
Complete structured claim and evidence

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Cure rate and egg reduction rate in treated infection