Component
Whole-body protein synthesis estimate
Whole-body protein synthesis estimate. Species, exposure and limitations are retained in each linked claim.
1 recorded relationships. Experimental role, claim status and evidence remain attached to each record.
How nutrients influence it
Every nutrient with a recorded effect on this component, credited to the nutrient that acted rather than the chapter that recorded it. Open a nutrient to see the findings and the conditions they were measured under.
Other things that act on it
Enzymes, hormones, genes, and other components with a recorded effect. These are not nutrients, so they do not count toward the arrows above. Each finding names the chapter that recorded it.
How nutrients reach it in more than one step
Chains of two or more recorded steps that end here, grouped by the nutrient they start from. Each step is a separate finding, so a chain is a route a mechanism could take, not proof that it does.
Tracing routes…
What it does
Every recorded relationship this component is part of, grouped by its role. Plain wording comes first; the technical statement follows.
What acts on it
Whole-body synthesis estimated by nonoxidative leucine disposal did not significantly change in the overall SBS group.
Experimental context and source evidence
- evidence_span
- {"source_cache": "artifacts/citrulline-research/30642738.abstract.txt", "locator": "Primary indexed abstract; zero-based, end-exclusive Unicode character offsets", "file_sha256": "0d8869660890cdf77bcc2056b8871bc7be2b4828791a4681c87657a8efe42737", "start_char": 0, "end_char": 2343, "text_sha256": "0d8869660890cdf77bcc2056b8871bc7be2b4828791a4681c87657a8efe42737"}
- experimental_model
- Double-blind crossover isotope study
- exposure
- 0.18 g/kg/day citrulline for seven days versus isonitrogenous placebo
- limitations
- Near-normal nutritional status long after surgery; exploratory low-baseline subgroups were too small for a treatment rule.
- nutrient_topic
- Citrulline research collection; topical membership is not evidence of a direct dietary effect. · L-Citrulline
- organism
- Human, nine adults with stable nonmalignant short-bowel syndrome
- plain_language
- Higher exposure did not establish an overall anabolic benefit.
- primary_references
- [citrulline-p30642738] Effect of oral citrulline supplementation on whole body protein metabolism in adult patients with short bowel syndrome: A pilot, randomized, double-blind, cross-over study. (2019). https://pubmed.ncbi.nlm.nih.gov/30642738/ DOI: 10.1016/j.clnu.2018.12.030
- tissue_or_cell_type
- Whole-body protein metabolism
Citrulline: arginine recycling, nitrogen disposal and nutrient connections (2026-09-17) · lines 1100–1111
AI-assisted literature curation; primary study URLs and scope retained in the document and extraction. Not publisher full text. · supports · Double-blind crossover isotope study · source_derived_draft · unverified_draft
### citrulline-sbs-protein-null Whole-body synthesis estimated by nonoxidative leucine disposal did not significantly change in the overall SBS group. Condition category: normal nutrient_topic: Citrulline research collection; topical membership is not evidence of a direct dietary effect. plain_language: Higher exposure did not establish an overall anabolic benefit. organism: Human, nine adults with stable nonmalignant short-bowel syndrome tissue_or_cell_type: Whole-body protein metabolism experimental_model: Double-blind crossover isotope study limitations: Near-normal nutritional status long after surgery; exploratory low-baseline subgroups were too small for a treatment rule. exposure: 0.18 g/kg/day citrulline for seven days versus isonitrogenous placebo evidence_span: {"source_cache": "artifacts/citrulline-research/30642738.abstract.txt", "locator": "Primary indexed abstract; zero-based, end-exclusive Unicode character offsets", "file_sha256": "0d8869660890cdf77bcc2056b8871bc7be2b4828791a4681c87657a8efe42737", "start_char": 0, "end_char": 2343, "text_sha256": "0d8869660890cdf77bcc2056b8871bc7be2b4828791a4681c87657a8efe42737"} [citrulline-p30642738] Effect of oral citrulline supplementation on whole body protein metabolism in adult patients with short bowel syndrome: A pilot, randomized, double-blind, cross-over study. (2019). https://pubmed.ncbi.nlm.nih.gov/30642738/ DOI: 10.1016/j.clnu.2018.12.030
Complete structured claim and evidence
The events it takes part in
A mechanism often involves more than two components. These are the full events, with every participant and its role.
Situations it appears in
Low-supply and faulty-machinery situations recorded in the chapters where this component plays a part.
In the sources
Preserved passages that mention this component, quoted exactly. Open one to read it in context.
Open hypotheses
Proposed ideas that involve this component. They are labeled as hypotheses and do not change any recorded statement.
This is a research prototype built from draft material. It is not medical advice, and its statements still await verification against the original studies.