Component
Whole-blood thyrotropin concentration
Whole-blood thyrotropin concentration. Study-specific scope and measurement methods are recorded with each claim.
1 recorded relationships. Experimental role, claim status and evidence remain attached to each record.
How nutrients influence it
Every nutrient with a recorded effect on this component, credited to the nutrient that acted rather than the chapter that recorded it. Open a nutrient to see the findings and the conditions they were measured under.
Other things that act on it
Enzymes, hormones, genes, and other components with a recorded effect. These are not nutrients, so they do not count toward the arrows above. Each finding names the chapter that recorded it.
How nutrients reach it in more than one step
Chains of two or more recorded steps that end here, grouped by the nutrient they start from. Each step is a separate finding, so a chain is a route a mechanism could take, not proof that it does.
Tracing routes…
What it does
Every recorded relationship this component is part of, grouped by its role. Plain wording comes first; the technical statement follows.
Where it participates (unsigned role)
The iron and placebo groups showed no significant difference in serum thyroxine or whole-blood thyrotropin at baseline or during the intervention.
Experimental context and source evidence
- availability_state
- nutrient_deficiency Imported condition classification; unverified.
- cross_nutrient
- true
- evidence_location
- Primary indexed abstract.
- experimental_model
- Randomized double-blind placebo-controlled trial in 166 goitrous iron-deficient children aged 5–14 in Côte d’Ivoire
- exposure
- All consumed iodized salt providing 10–30 mg iodine/kg salt at household level; iron group received 60 mg elemental Fe/day, four days/week for 16 weeks; outcomes followed to 20 weeks.
- limitations
- This tests iron treatment on a background of iodine supply. It does not directly measure TPO activity or prove that iron deficiency always prevents iodine response. Specific iron-supplement salt not verified from abstract. The whole-blood thyrotropin assay is identified explicitly; it is not claimed to be the same specimen matrix as serum TSH.
- nutrient_topic
- Iodine research collection; topical membership is not evidence of a direct dietary effect. · Iodine
- organism
- Homo sapiens
- plain_language
- Improved thyroid size did not mean every hormone measurement changed.
- primary_references
- [iod-clin-hess2002] Treatment of iron deficiency in goitrous children improves the efficacy of iodized salt in Côte d'Ivoire. (2002). https://pubmed.ncbi.nlm.nih.gov/11916762/ DOI: 10.1093/ajcn/75.4.743
- tissue_or_cell_type
- Thyroid ultrasound and blood thyroid indices
- trigger_kind
- nutrient_deficiency Imported condition classification; unverified.
Iodine: thyroid hormone production, deficiency, excess and nutrient interactions (2026-09-17) · lines 1216–1228
AI-assisted literature curation; primary study URLs and scope retained in the document and extraction. Not publisher full text. · supports · Randomized double-blind placebo-controlled trial in 166 goitrous iron-deficient children aged 5–14 in Côte d’Ivoire · source_derived_draft · unverified_draft
### iod-clin-iron-salt-hormone-null The iron and placebo groups showed no significant difference in serum thyroxine or whole-blood thyrotropin at baseline or during the intervention. Condition category: nutrient_deficiency nutrient_topic: Iodine research collection; topical membership is not evidence of a direct dietary effect. plain_language: Improved thyroid size did not mean every hormone measurement changed. organism: Homo sapiens tissue_or_cell_type: Thyroid ultrasound and blood thyroid indices experimental_model: Randomized double-blind placebo-controlled trial in 166 goitrous iron-deficient children aged 5–14 in Côte d’Ivoire limitations: This tests iron treatment on a background of iodine supply. It does not directly measure TPO activity or prove that iron deficiency always prevents iodine response. Specific iron-supplement salt not verified from abstract. The whole-blood thyrotropin assay is identified explicitly; it is not claimed to be the same specimen matrix as serum TSH. exposure: All consumed iodized salt providing 10–30 mg iodine/kg salt at household level; iron group received 60 mg elemental Fe/day, four days/week for 16 weeks; outcomes followed to 20 weeks. cross_nutrient: true evidence_location: Primary indexed abstract. [iod-clin-hess2002] Treatment of iron deficiency in goitrous children improves the efficacy of iodized salt in Côte d'Ivoire. (2002). https://pubmed.ncbi.nlm.nih.gov/11916762/ DOI: 10.1093/ajcn/75.4.743
Complete structured claim and evidence
The events it takes part in
A mechanism often involves more than two components. These are the full events, with every participant and its role.
Situations it appears in
Low-supply and faulty-machinery situations recorded in the chapters where this component plays a part.
In the sources
Preserved passages that mention this component, quoted exactly. Open one to read it in context.
Open hypotheses
Proposed ideas that involve this component. They are labeled as hypotheses and do not change any recorded statement.
This is a research prototype built from draft material. It is not medical advice, and its statements still await verification against the original studies.