{"id":"8e8cf8e9-4aed-55fa-884e-88e9255d1002","stable_key":"aaa7baba-8689-56ab-ba1e-b71542bcb8e9:iod-clin-iron-salt-hormone-null","predicate":"repletion-does-not-significantly-change","statement":"The iron and placebo groups showed no significant difference in serum thyroxine or whole-blood thyrotropin at baseline or during the intervention.","claim_class":"observational","status":"source_derived_draft","evidence_grade":"ungraded","direction":"neutral","is_public":true,"mechanism_event_id":"317a4d8d-f590-565d-ac80-507321eb31b0","mechanism_event_label":"Improved thyroid size did not mean every hormone measurement changed.","subject":{"id":"89bcaf42-b4ab-5760-8c2e-44eace10cee0","slug":"iron","display_name":"Iron","entity_type_key":"nutrient_element"},"object":{"id":"90c33fc7-1fee-5949-a863-a7848a22123f","slug":"serum-total-t4-concentration","display_name":"Serum total thyroxine concentration","entity_type_key":"cellular_process"},"evidence_count":1,"mechanism_event":{"id":"317a4d8d-f590-565d-ac80-507321eb31b0","stable_key":"aaa7baba-8689-56ab-ba1e-b71542bcb8e9:iod-clin-iron-salt-hormone-null-event","event_type":"observed_intervention","label":"Improved thyroid size did not mean every hormone measurement changed.","description":"The iron and placebo groups showed no significant difference in serum thyroxine or whole-blood thyrotropin at baseline or during the intervention.","status":"provisional","compartment":null,"participants":[{"entity":{"id":"0e0ac6d1-3336-506a-9f69-5838ca1500ed","slug":"iodine","display_name":"Iodine","entity_type_key":"nutrient_element"},"role":"background iodine","stoichiometry":null,"state_label":"","sequence_order":0,"notes":""},{"entity":{"id":"e29544af-a81a-5315-9c41-3120d3688937","slug":"whole-blood-thyrotropin-concentration","display_name":"Whole-blood thyrotropin concentration","entity_type_key":"cellular_process"},"role":"whole-blood assay endpoint","stoichiometry":null,"state_label":"","sequence_order":1,"notes":""},{"entity":{"id":"89bcaf42-b4ab-5760-8c2e-44eace10cee0","slug":"iron","display_name":"Iron","entity_type_key":"nutrient_element"},"role":"subject","stoichiometry":null,"state_label":"","sequence_order":2,"notes":""},{"entity":{"id":"90c33fc7-1fee-5949-a863-a7848a22123f","slug":"serum-total-t4-concentration","display_name":"Serum total thyroxine concentration","entity_type_key":"cellular_process"},"role":"target","stoichiometry":null,"state_label":"","sequence_order":3,"notes":""}]},"contexts":[{"dimension":"availability_state","value_text":"nutrient_deficiency","comparator":null,"unit":null,"notes":"Imported condition classification; unverified.","entity":null},{"dimension":"cross_nutrient","value_text":"true","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"evidence_location","value_text":"Primary indexed abstract.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"experimental_model","value_text":"Randomized double-blind placebo-controlled trial in 166 goitrous iron-deficient children aged 5–14 in Côte d’Ivoire","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"exposure","value_text":"All consumed iodized salt providing 10–30 mg iodine/kg salt at household level; iron group received 60 mg elemental Fe/day, four days/week for 16 weeks; outcomes followed to 20 weeks.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"limitations","value_text":"This tests iron treatment on a background of iodine supply. It does not directly measure TPO activity or prove that iron deficiency always prevents iodine response. Specific iron-supplement salt not verified from abstract. The whole-blood thyrotropin assay is identified explicitly; it is not claimed to be the same specimen matrix as serum TSH.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"nutrient_topic","value_text":"Iodine research collection; topical membership is not evidence of a direct dietary effect.","comparator":null,"unit":null,"notes":"","entity":{"slug":"iodine","display_name":"Iodine","entity_type_key":"nutrient_element"}},{"dimension":"organism","value_text":"Homo sapiens","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"plain_language","value_text":"Improved thyroid size did not mean every hormone measurement changed.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"primary_references","value_text":"[iod-clin-hess2002] Treatment of iron deficiency in goitrous children improves the efficacy of iodized salt in Côte d'Ivoire. (2002). https://pubmed.ncbi.nlm.nih.gov/11916762/ DOI: 10.1093/ajcn/75.4.743","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"tissue_or_cell_type","value_text":"Thyroid ultrasound and blood thyroid indices","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"trigger_kind","value_text":"nutrient_deficiency","comparator":null,"unit":null,"notes":"Imported condition classification; unverified.","entity":null}],"evidence":[{"id":"f7ff33f0-112e-571a-b453-2f62a6a7240d","evidence_kind":"source_excerpt","locator":"Lines 1216-1228","start_line":1216,"end_line":1228,"excerpt":"### iod-clin-iron-salt-hormone-null\nThe iron and placebo groups showed no significant difference in serum thyroxine or whole-blood thyrotropin at baseline or during the intervention.\nCondition category: nutrient_deficiency\nnutrient_topic: Iodine research collection; topical membership is not evidence of a direct dietary effect.\nplain_language: Improved thyroid size did not mean every hormone measurement changed.\norganism: Homo sapiens\ntissue_or_cell_type: Thyroid ultrasound and blood thyroid indices\nexperimental_model: Randomized double-blind placebo-controlled trial in 166 goitrous iron-deficient children aged 5–14 in Côte d’Ivoire\nlimitations: This tests iron treatment on a background of iodine supply. It does not directly measure TPO activity or prove that iron deficiency always prevents iodine response. Specific iron-supplement salt not verified from abstract. The whole-blood thyrotropin assay is identified explicitly; it is not claimed to be the same specimen matrix as serum TSH.\nexposure: All consumed iodized salt providing 10–30 mg iodine/kg salt at household level; iron group received 60 mg elemental Fe/day, four days/week for 16 weeks; outcomes followed to 20 weeks.\ncross_nutrient: true\nevidence_location: Primary indexed abstract.\n[iod-clin-hess2002] Treatment of iron deficiency in goitrous children improves the efficacy of iodized salt in Côte d'Ivoire. 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