Component
VCP/p97
Independent protein record for Valosin-containing protein.
2 recorded relationships. Experimental role, claim status and evidence remain attached to each record.
How nutrients influence it
Every nutrient with a recorded effect on this component, credited to the nutrient that acted rather than the chapter that recorded it. Open a nutrient to see the findings and the conditions they were measured under.
Other things that act on it
Enzymes, hormones, genes, and other components with a recorded effect. These are not nutrients, so they do not count toward the arrows above. Each finding names the chapter that recorded it.
How nutrients reach it in more than one step
Chains of two or more recorded steps that end here, grouped by the nutrient they start from. Each step is a separate finding, so a chain is a route a mechanism could take, not proof that it does.
Tracing routes…
What it does
Every recorded relationship this component is part of, grouped by its role. Plain wording comes first; the technical statement follows.
What acts on it
SELENOS interacts with p97/VCP; mutation of Pro178 or Pro183 disrupted this association in the tested cell experiments.
Experimental context and source evidence
- experimental_model
- Cultured-cell SELENOS mutation, protein-interaction and degradation assays.
- limitations
- This experiment-specific relationship does not establish a human dietary-deficiency threshold or supplementation benefit.
- organism
- Cultured mammalian cells
Selenium: literature corrections and mechanism additions · lines 1075–1084
Metabolic Ledger literature curation, 17 September 2026; primary papers linked individually · supports · Cultured-cell SELENOS mutation, protein-interaction and degradation assays. · secondary_verified · secondary_verified
## selenos-binds-p97 SELENOS helps connect ER quality control to the p97 protein-handling machinery. SELENOS interacts with p97/VCP; mutation of Pro178 or Pro183 disrupted this association in the tested cell experiments. Experimental model: Cultured-cell SELENOS mutation, protein-interaction and degradation assays. Organism: Cultured mammalian cells Limitations: This experiment-specific relationship does not establish a human dietary-deficiency threshold or supplementation benefit. Primary reference: [Pro178 and Pro183 of Selenoprotein S Are Essential Residues for Interaction with p97 during ER-associated Degradation](https://pmc.ncbi.nlm.nih.gov/articles/PMC4022850/)
Complete structured claim and evidence
Where it participates (unsigned role)
SELENOS-p97 interaction contributes to degradation of the ERAD substrate tested in the mutational study.
Experimental context and source evidence
- experimental_model
- Cultured-cell SELENOS mutation, protein-interaction and degradation assays.
- limitations
- Do not generalize one substrate assay to every ERAD substrate or assume dietary deficiency reproduces a binding-site mutation.
- organism
- Cultured mammalian cells
Selenium: literature corrections and mechanism additions · lines 1086–1095
Metabolic Ledger literature curation, 17 September 2026; primary papers linked individually · supports · Cultured-cell SELENOS mutation, protein-interaction and degradation assays. · secondary_verified · secondary_verified
## selenos-supports-erad The SELENOS-p97 connection helps dispose of a tested faulty protein. SELENOS-p97 interaction contributes to degradation of the ERAD substrate tested in the mutational study. Experimental model: Cultured-cell SELENOS mutation, protein-interaction and degradation assays. Organism: Cultured mammalian cells Limitations: Do not generalize one substrate assay to every ERAD substrate or assume dietary deficiency reproduces a binding-site mutation. Primary reference: [Pro178 and Pro183 of Selenoprotein S Are Essential Residues for Interaction with p97 during ER-associated Degradation](https://pmc.ncbi.nlm.nih.gov/articles/PMC4022850/)
Complete structured claim and evidence
The events it takes part in
A mechanism often involves more than two components. These are the full events, with every participant and its role.
Situations it appears in
Low-supply and faulty-machinery situations recorded in the chapters where this component plays a part.
In the sources
Preserved passages that mention this component, quoted exactly. Open one to read it in context.
Open hypotheses
Proposed ideas that involve this component. They are labeled as hypotheses and do not change any recorded statement.
This is a research prototype built from draft material. It is not medical advice, and its statements still await verification against the original studies.