Component
Vascular superoxide production, model specified
Vascular superoxide production, model specified. Species, exposure and limitations are retained in each linked claim.
1 recorded relationships. Experimental role, claim status and evidence remain attached to each record.
How nutrients influence it
Every nutrient with a recorded effect on this component, credited to the nutrient that acted rather than the chapter that recorded it. Open a nutrient to see the findings and the conditions they were measured under.
Other things that act on it
Enzymes, hormones, genes, and other components with a recorded effect. These are not nutrients, so they do not count toward the arrows above. Each finding names the chapter that recorded it.
How nutrients reach it in more than one step
Chains of two or more recorded steps that end here, grouped by the nutrient they start from. Each step is a separate finding, so a chain is a route a mechanism could take, not proof that it does.
Tracing routes…
What it does
Every recorded relationship this component is part of, grouped by its role. Plain wording comes first; the technical statement follows.
What acts on it
5-MTHF reduced vascular superoxide; the effect was not explained by direct superoxide scavenging or changed plasma homocysteine.
Experimental context and source evidence
- evidence_span
- {"source_cache": "artifacts/citrulline-research/16940192.abstract.txt", "locator": "Primary indexed abstract; zero-based, end-exclusive Unicode character offsets", "file_sha256": "42c07dd0bbacfc1ff44f78d6ce69810a58946e53c76bf5d3bf8385db5278ba8b", "start_char": 0, "end_char": 1942, "text_sha256": "42c07dd0bbacfc1ff44f78d6ce69810a58946e53c76bf5d3bf8385db5278ba8b"}
- experimental_model
- Ex-vivo vessel exposure and randomized pre-harvest infusion
- exposure
- 5-MTHF ex vivo 1-100 micromolar; intravenous 5-MTHF or placebo in a separate subset
- limitations
- Uses 5-MTHF and acute vessel endpoints; cannot be generalized to all folic-acid doses or combination supplements.
- nutrient_topic
- Citrulline research collection; topical membership is not evidence of a direct dietary effect. · L-Citrulline
- organism
- Human, vessels from 117 CABG patients
- plain_language
- The experiment distinguished this effect from simply lowering homocysteine.
- primary_references
- [citrulline-p16940192] 5-methyltetrahydrofolate rapidly improves endothelial function and decreases superoxide production in human vessels: effects on vascular tetrahydrobiopterin availability and endothelial nitric oxide synthase coupling. (2006). https://pubmed.ncbi.nlm.nih.gov/16940192/ DOI: 10.1161/circulationaha.106.612325
- tissue_or_cell_type
- Saphenous veins and internal mammary arteries
Citrulline: arginine recycling, nitrogen disposal and nutrient connections (2026-09-17) · lines 762–773
AI-assisted literature curation; primary study URLs and scope retained in the document and extraction. Not publisher full text. · supports · Ex-vivo vessel exposure and randomized pre-harvest infusion · source_derived_draft · unverified_draft
### citrulline-folate-superoxide 5-MTHF reduced vascular superoxide; the effect was not explained by direct superoxide scavenging or changed plasma homocysteine. Condition category: normal nutrient_topic: Citrulline research collection; topical membership is not evidence of a direct dietary effect. plain_language: The experiment distinguished this effect from simply lowering homocysteine. organism: Human, vessels from 117 CABG patients tissue_or_cell_type: Saphenous veins and internal mammary arteries experimental_model: Ex-vivo vessel exposure and randomized pre-harvest infusion limitations: Uses 5-MTHF and acute vessel endpoints; cannot be generalized to all folic-acid doses or combination supplements. exposure: 5-MTHF ex vivo 1-100 micromolar; intravenous 5-MTHF or placebo in a separate subset evidence_span: {"source_cache": "artifacts/citrulline-research/16940192.abstract.txt", "locator": "Primary indexed abstract; zero-based, end-exclusive Unicode character offsets", "file_sha256": "42c07dd0bbacfc1ff44f78d6ce69810a58946e53c76bf5d3bf8385db5278ba8b", "start_char": 0, "end_char": 1942, "text_sha256": "42c07dd0bbacfc1ff44f78d6ce69810a58946e53c76bf5d3bf8385db5278ba8b"} [citrulline-p16940192] 5-methyltetrahydrofolate rapidly improves endothelial function and decreases superoxide production in human vessels: effects on vascular tetrahydrobiopterin availability and endothelial nitric oxide synthase coupling. (2006). https://pubmed.ncbi.nlm.nih.gov/16940192/ DOI: 10.1161/circulationaha.106.612325
Complete structured claim and evidence
The events it takes part in
A mechanism often involves more than two components. These are the full events, with every participant and its role.
Situations it appears in
Low-supply and faulty-machinery situations recorded in the chapters where this component plays a part.
In the sources
Preserved passages that mention this component, quoted exactly. Open one to read it in context.
Open hypotheses
Proposed ideas that involve this component. They are labeled as hypotheses and do not change any recorded statement.
This is a research prototype built from draft material. It is not medical advice, and its statements still await verification against the original studies.