Component
Electrically evoked twitch response of the mouse vas deferens
Electrically evoked twitch response of the mouse vas deferens. Species, exposure and limitations are retained in each linked claim.
1 recorded relationships. Experimental role, claim status and evidence remain attached to each record.
How nutrients influence it
Every nutrient with a recorded effect on this component, credited to the nutrient that acted rather than the chapter that recorded it. Open a nutrient to see the findings and the conditions they were measured under.
Other things that act on it
Enzymes, hormones, genes, and other components with a recorded effect. These are not nutrients, so they do not count toward the arrows above. Each finding names the chapter that recorded it.
How nutrients reach it in more than one step
Chains of two or more recorded steps that end here, grouped by the nutrient they start from. Each step is a separate finding, so a chain is a route a mechanism could take, not proof that it does.
Tracing routes…
What it does
Every recorded relationship this component is part of, grouped by its role. Plain wording comes first; the technical statement follows.
Where it participates (unsigned role)
Arachidonylethanolamide, an arachidonic acid derivative isolated from porcine brain, competitively inhibited binding of a radiolabelled cannabinoid probe to synaptosomal membranes and produced concentration-dependent inhibition of the electrically evoked twitch of the mouse vas deferens, a characteristic effect of psychotropic cannabinoids.
Experimental context and source evidence
- evidence_span
- {"source_cache": "artifacts/thc-research/1470919.abstract.txt", "locator": "Indexed abstract; zero-based, end-exclusive Unicode character offsets", "file_sha256": "45d534b5ac88c3edf040431942aea2f8421399c88e3931e8bc28b4b5e438f2f2", "start_char": 0, "end_char": 757, "text_sha256": "45d534b5ac88c3edf040431942aea2f8421399c88e3931e8bc28b4b5e438f2f2"}
- experimental_model
- Isolation from porcine brain with mass spectrometry, NMR and synthetic confirmation
- exposure
- Screen for endogenous ligands of the cannabinoid receptor
- limitations
- The isolation of the first endogenous ligand. The bioassay is a peripheral tissue twitch, not a central behavioural effect.
- nutrient_topic
- THC research collection; topical membership is not evidence of a direct clinical effect, and THC is recorded separately from the endocannabinoids it imitates. · Delta-9-tetrahydrocannabinol / THC
- organism
- Pig brain, with mouse bioassay
- plain_language
- The brain makes its own version of the drug, and it is built from a fatty acid.
- primary_references
- [thc-p1470919] Isolation and structure of a brain constituent that binds to the cannabinoid receptor. (1992). https://pubmed.ncbi.nlm.nih.gov/1470919/ DOI: 10.1126/science.1470919
- tissue_or_cell_type
- Brain and vas deferens
THC: the cannabinoid receptors, the endocannabinoid system it occupies, what the drug does, and the dietary fat it is built from (2026-09-21) · lines 244–255
AI-assisted literature curation; primary study URLs and scope retained in the document and extraction. Not publisher full text. · supports · Isolation from porcine brain with mass spectrometry, NMR and synthetic confirmation · source_derived_draft · unverified_draft
### thc-anandamide-isolated Arachidonylethanolamide, an arachidonic acid derivative isolated from porcine brain, competitively inhibited binding of a radiolabelled cannabinoid probe to synaptosomal membranes and produced concentration-dependent inhibition of the electrically evoked twitch of the mouse vas deferens, a characteristic effect of psychotropic cannabinoids. Condition category: normal nutrient_topic: THC research collection; topical membership is not evidence of a direct clinical effect, and THC is recorded separately from the endocannabinoids it imitates. plain_language: The brain makes its own version of the drug, and it is built from a fatty acid. organism: Pig brain, with mouse bioassay tissue_or_cell_type: Brain and vas deferens experimental_model: Isolation from porcine brain with mass spectrometry, NMR and synthetic confirmation limitations: The isolation of the first endogenous ligand. The bioassay is a peripheral tissue twitch, not a central behavioural effect. exposure: Screen for endogenous ligands of the cannabinoid receptor evidence_span: {"source_cache": "artifacts/thc-research/1470919.abstract.txt", "locator": "Indexed abstract; zero-based, end-exclusive Unicode character offsets", "file_sha256": "45d534b5ac88c3edf040431942aea2f8421399c88e3931e8bc28b4b5e438f2f2", "start_char": 0, "end_char": 757, "text_sha256": "45d534b5ac88c3edf040431942aea2f8421399c88e3931e8bc28b4b5e438f2f2"} [thc-p1470919] Isolation and structure of a brain constituent that binds to the cannabinoid receptor. (1992). https://pubmed.ncbi.nlm.nih.gov/1470919/ DOI: 10.1126/science.1470919
Complete structured claim and evidence
The events it takes part in
A mechanism often involves more than two components. These are the full events, with every participant and its role.
Situations it appears in
Low-supply and faulty-machinery situations recorded in the chapters where this component plays a part.
In the sources
Preserved passages that mention this component, quoted exactly. Open one to read it in context.
Open hypotheses
Proposed ideas that involve this component. They are labeled as hypotheses and do not change any recorded statement.
This is a research prototype built from draft material. It is not medical advice, and its statements still await verification against the original studies.