Component
Hepatic urea-cycle enzyme levels
Hepatic urea-cycle enzyme levels. Species, exposure and limitations are retained in each linked claim.
1 recorded relationships. Experimental role, claim status and evidence remain attached to each record.
How nutrients influence it
Every nutrient with a recorded effect on this component, credited to the nutrient that acted rather than the chapter that recorded it. Open a nutrient to see the findings and the conditions they were measured under.
Other things that act on it
Enzymes, hormones, genes, and other components with a recorded effect. These are not nutrients, so they do not count toward the arrows above. Each finding names the chapter that recorded it.
How nutrients reach it in more than one step
Chains of two or more recorded steps that end here, grouped by the nutrient they start from. Each step is a separate finding, so a chain is a route a mechanism could take, not proof that it does.
Tracing routes…
What it does
Every recorded relationship this component is part of, grouped by its role. Plain wording comes first; the technical statement follows.
Where it participates (unsigned role)
In young male ferrets made hyperammonaemic and comatose by brief feeding of an arginine-deficient diet, synergism of the three factors hyperammonaemia, influenza infection and aspirin treatment was observed in causing Reye-syndrome-like alterations in serum ammonia, transaminase, ornithine carbamoyltransferase, bilirubin and salicylate levels and in liver lipids, proteins and urea-cycle enzymes; the relationship of aspirin treatment to influenza and ammonia toxicity cannot be examined directly in patients because aspirin is usually started by family members in the prodrome before the syndrome is diagnosed.
Experimental context and source evidence
- availability_state
- biomarker_context Imported condition classification; unverified.
- evidence_span
- {"source_cache": "artifacts/aspirin-research/6961432.abstract.txt", "locator": "Indexed abstract; zero-based, end-exclusive Unicode character offsets", "file_sha256": "53631b4bef8684ad8023f1dcc822f8191323e61fd073a93ce4c4872916cb5beb", "start_char": 0, "end_char": 1430, "text_sha256": "53631b4bef8684ad8023f1dcc822f8191323e61fd073a93ce4c4872916cb5beb"}
- experimental_model
- Factorial study in young male ferrets made hyperammonaemic by brief arginine-deficient feeding
- exposure
- Influenza infection and aspirin treatment, alone and together, in control and hyperammonaemic animals
- limitations
- An animal model of a syndrome whose human definition is clinical, testing three factors that cannot be separated in patients because dosing precedes diagnosis. Synergism is reported across biochemical parameters rather than as a disease endpoint.
- nutrient_topic
- Aspirin research collection; topical membership is not evidence of a direct clinical effect, and aspirin is recorded separately from salicylate, the metabolite it becomes. · Aspirin / acetylsalicylic acid
- organism
- Ferret
- plain_language
- In this model aspirin only does damage alongside a viral infection and a failing urea cycle; no one factor is enough.
- primary_references
- [asa-p6961432] Interactions of aspirin and other potential etiologic factors in an animal model of Reye syndrome. (1982). https://pubmed.ncbi.nlm.nih.gov/6961432/ DOI: 10.1073/pnas.79.23.7557
- tissue_or_cell_type
- Liver and blood
- trigger_kind
- biomarker_context Imported condition classification; unverified.
AI-assisted literature curation; primary study URLs and scope retained in the document and extraction. Not publisher full text. · supports · Factorial study in young male ferrets made hyperammonaemic by brief arginine-deficient feeding · source_derived_draft · unverified_draft
### asa-reye-needs-three-factors In young male ferrets made hyperammonaemic and comatose by brief feeding of an arginine-deficient diet, synergism of the three factors hyperammonaemia, influenza infection and aspirin treatment was observed in causing Reye-syndrome-like alterations in serum ammonia, transaminase, ornithine carbamoyltransferase, bilirubin and salicylate levels and in liver lipids, proteins and urea-cycle enzymes; the relationship of aspirin treatment to influenza and ammonia toxicity cannot be examined directly in patients because aspirin is usually started by family members in the prodrome before the syndrome is diagnosed. Condition category: biomarker_context nutrient_topic: Aspirin research collection; topical membership is not evidence of a direct clinical effect, and aspirin is recorded separately from salicylate, the metabolite it becomes. plain_language: In this model aspirin only does damage alongside a viral infection and a failing urea cycle; no one factor is enough. organism: Ferret tissue_or_cell_type: Liver and blood experimental_model: Factorial study in young male ferrets made hyperammonaemic by brief arginine-deficient feeding limitations: An animal model of a syndrome whose human definition is clinical, testing three factors that cannot be separated in patients because dosing precedes diagnosis. Synergism is reported across biochemical parameters rather than as a disease endpoint. exposure: Influenza infection and aspirin treatment, alone and together, in control and hyperammonaemic animals evidence_span: {"source_cache": "artifacts/aspirin-research/6961432.abstract.txt", "locator": "Indexed abstract; zero-based, end-exclusive Unicode character offsets", "file_sha256": "53631b4bef8684ad8023f1dcc822f8191323e61fd073a93ce4c4872916cb5beb", "start_char": 0, "end_char": 1430, "text_sha256": "53631b4bef8684ad8023f1dcc822f8191323e61fd073a93ce4c4872916cb5beb"} [asa-p6961432] Interactions of aspirin and other potential etiologic factors in an animal model of Reye syndrome. (1982). https://pubmed.ncbi.nlm.nih.gov/6961432/ DOI: 10.1073/pnas.79.23.7557
Complete structured claim and evidence
The events it takes part in
A mechanism often involves more than two components. These are the full events, with every participant and its role.
Situations it appears in
Low-supply and faulty-machinery situations recorded in the chapters where this component plays a part.
In the sources
Preserved passages that mention this component, quoted exactly. Open one to read it in context.
Open hypotheses
Proposed ideas that involve this component. They are labeled as hypotheses and do not change any recorded statement.
This is a research prototype built from draft material. It is not medical advice, and its statements still await verification against the original studies.