{"id":"8fa28d1c-2164-560f-82d4-3924d645ecef","stable_key":"f8641d02-8413-5bd8-92e9-62ad49286e81:asa-reye-needs-three-factors","predicate":"causes","statement":"In young male ferrets made hyperammonaemic and comatose by brief feeding of an arginine-deficient diet, synergism of the three factors hyperammonaemia, influenza infection and aspirin treatment was observed in causing Reye-syndrome-like alterations in serum ammonia, transaminase, ornithine carbamoyltransferase, bilirubin and salicylate levels and in liver lipids, proteins and urea-cycle enzymes; the relationship of aspirin treatment to influenza and ammonia toxicity cannot be examined directly in patients because aspirin is usually started by family members in the prodrome before the syndrome is diagnosed.","claim_class":"observational","status":"source_derived_draft","evidence_grade":"ungraded","direction":"positive","is_public":true,"mechanism_event_id":"cf613083-f7fe-5022-afe7-8b10fee116fc","mechanism_event_label":"In this model aspirin only does damage alongside a viral infection and a failing urea cycle; 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Synergism is reported across biochemical parameters rather than as a disease endpoint.\nexposure: Influenza infection and aspirin treatment, alone and together, in control and hyperammonaemic animals\nevidence_span: {\"source_cache\": \"artifacts/aspirin-research/6961432.abstract.txt\", \"locator\": \"Indexed abstract; zero-based, end-exclusive Unicode character offsets\", \"file_sha256\": \"53631b4bef8684ad8023f1dcc822f8191323e61fd073a93ce4c4872916cb5beb\", \"start_char\": 0, \"end_char\": 1430, \"text_sha256\": \"53631b4bef8684ad8023f1dcc822f8191323e61fd073a93ce4c4872916cb5beb\"}\n[asa-p6961432] Interactions of aspirin and other potential etiologic factors in an animal model of Reye syndrome. 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