Component
TRPV1 calcium-dependent desensitization
Species, preparation, dose and limitations are retained on linked claims.
1 recorded relationships. Experimental role, claim status and evidence remain attached to each record.
How nutrients influence it
Every nutrient with a recorded effect on this component, credited to the nutrient that acted rather than the chapter that recorded it. Open a nutrient to see the findings and the conditions they were measured under.
Other things that act on it
Enzymes, hormones, genes, and other components with a recorded effect. These are not nutrients, so they do not count toward the arrows above. Each finding names the chapter that recorded it.
How nutrients reach it in more than one step
Chains of two or more recorded steps that end here, grouped by the nutrient they start from. Each step is a separate finding, so a chain is a route a mechanism could take, not proof that it does.
Tracing routes…
What it does
Every recorded relationship this component is part of, grouped by its role. Plain wording comes first; the technical statement follows.
What acts on it
Repeated capsaicin activation caused calcium-dependent TRPV1 desensitization regulated in part by calcineurin and PKA at Thr370.
Experimental context and source evidence
- dose
- Repeated capsaicin; calcineurin inhibitor, forskolin and point mutants
- duration
- Acute repeated activation
- evidence_access
- Primary PubMed abstract and indexed metadata reviewed. Full-text method details not stated here remain unresolved.
- evidence_scope
- literature_reviewed; model-specific source-derived curation
- experimental_model
- TRPV1-transfected HEK293T or HeLa cells
- limitations
- Kinase and phosphatase manipulations identify regulatory machinery in engineered cells, not a dietary calcium threshold.
- nutrient_topic
- Capsaicin chapter; interacting nutrients, drugs, peptides and proteins retain their experimental settings. · Capsaicin
- organism
- TRPV1-transfected HEK293T or HeLa cells
- plain_language
- Repeated capsaicin activation caused calcium-dependent TRPV1 desensitization regulated in part by calcineurin and PKA at Thr370.
- primary_references
- Regulation of Ca2+-dependent desensitization in the vanilloid receptor TRPV1 by calcineurin and cAMP-dependent protein kinase. (2005). https://pubmed.ncbi.nlm.nih.gov/15691846/ DOI: 10.1074/jbc.M410917200
- route
- In vitro
- tissue
- Whole-cell capsaicin currents
Capsaicin: mechanism of action and interactions (2026-09-20) · lines 33–42
Original AI-assisted source-specific curation with primary-study citations, model, exposure, route, duration, negative findings and limitations preserved. Not publisher full text. · supports · TRPV1-transfected HEK293T or HeLa cells · source_derived_draft · unverified_draft
## capsaicin-calcineurin-desensitization Repeated capsaicin activation caused calcium-dependent TRPV1 desensitization regulated in part by calcineurin and PKA at Thr370. Model/species: TRPV1-transfected HEK293T or HeLa cells Tissue/system: Whole-cell capsaicin currents Exposure: Repeated capsaicin; calcineurin inhibitor, forskolin and point mutants Route: In vitro Duration: Acute repeated activation Limits: Kinase and phosphatase manipulations identify regulatory machinery in engineered cells, not a dietary calcium threshold. Primary reference: Regulation of Ca2+-dependent desensitization in the vanilloid receptor TRPV1 by calcineurin and cAMP-dependent protein kinase. (2005). https://pubmed.ncbi.nlm.nih.gov/15691846/ DOI: 10.1074/jbc.M410917200 Access: Primary PubMed abstract and indexed metadata reviewed. Full-text method details not stated here remain unresolved.
Complete structured claim and evidence
The events it takes part in
A mechanism often involves more than two components. These are the full events, with every participant and its role.
Situations it appears in
Low-supply and faulty-machinery situations recorded in the chapters where this component plays a part.
In the sources
Preserved passages that mention this component, quoted exactly. Open one to read it in context.
Open hypotheses
Proposed ideas that involve this component. They are labeled as hypotheses and do not change any recorded statement.
This is a research prototype built from draft material. It is not medical advice, and its statements still await verification against the original studies.