Component
TRPM6 S141L
Disease-associated serine-141-to-leucine TRPM6 variant.
1 recorded relationships. Experimental role, claim status and evidence remain attached to each record.
How nutrients influence it
Every nutrient with a recorded effect on this component, credited to the nutrient that acted rather than the chapter that recorded it. Open a nutrient to see the findings and the conditions they were measured under.
Other things that act on it
Enzymes, hormones, genes, and other components with a recorded effect. These are not nutrients, so they do not count toward the arrows above. Each finding names the chapter that recorded it.
How nutrients reach it in more than one step
Chains of two or more recorded steps that end here, grouped by the nutrient they start from. Each step is a separate finding, so a chain is a route a mechanism could take, not proof that it does.
Tracing routes…
What it does
Every recorded relationship this component is part of, grouped by its role. Plain wording comes first; the technical statement follows.
What it acts on
TRPM6 S141L disrupted oligomeric assembly and functional TRPM6/TRPM7 complex formation.
Experimental context and source evidence
- availability_state
- machinery_impairment Imported condition classification; unverified.
- evidence-system
- Mutant coexpression and channel assembly assays
- experimental_model
- Mutant coexpression and channel assembly assays
- limitations
- A particular variant mechanism; not all TRPM6 variants act by defective trafficking.
- nutrient_topic
- Magnesium research collection; topical membership is not evidence of a direct dietary effect. · Magnesium
- organism
- Human proteins
- plain_language
- This disease-associated substitution damages assembly of the magnesium-entry machinery.
- primary_references
- [chubanov-2004-trpm6-trpm7] Disruption of TRPM6/TRPM7 complex formation by a mutation in the TRPM6 gene causes hypomagnesemia with secondary hypocalcemia. (2004). https://pubmed.ncbi.nlm.nih.gov/14976260/ DOI: 10.1073/pnas.0305252101
- tissue
- HEK293 and Xenopus expression systems
- tissue_or_cell_type
- HEK293 and Xenopus expression systems
- trigger_kind
- machinery_impairment Imported condition classification; unverified.
Magnesium: cross-nutrient mechanisms and deficiency (2026-09-17) · lines 896–907
AI-assisted literature curation; primary study URLs and scope retained in the document and extraction. Not publisher full text. · supports · Mutant coexpression and channel assembly assays · source_derived_draft · unverified_draft
### trpm6-s141l-assembly-defect TRPM6 S141L disrupted oligomeric assembly and functional TRPM6/TRPM7 complex formation. Condition category: machinery_impairment nutrient_topic: Magnesium research collection; topical membership is not evidence of a direct dietary effect. plain_language: This disease-associated substitution damages assembly of the magnesium-entry machinery. organism: Human proteins tissue_or_cell_type: HEK293 and Xenopus expression systems experimental_model: Mutant coexpression and channel assembly assays limitations: A particular variant mechanism; not all TRPM6 variants act by defective trafficking. evidence-system: Mutant coexpression and channel assembly assays tissue: HEK293 and Xenopus expression systems [chubanov-2004-trpm6-trpm7] Disruption of TRPM6/TRPM7 complex formation by a mutation in the TRPM6 gene causes hypomagnesemia with secondary hypocalcemia. (2004). https://pubmed.ncbi.nlm.nih.gov/14976260/ DOI: 10.1073/pnas.0305252101
Complete structured claim and evidence
The events it takes part in
A mechanism often involves more than two components. These are the full events, with every participant and its role.
Situations it appears in
Low-supply and faulty-machinery situations recorded in the chapters where this component plays a part.
In the sources
Preserved passages that mention this component, quoted exactly. Open one to read it in context.
Open hypotheses
Proposed ideas that involve this component. They are labeled as hypotheses and do not change any recorded statement.
This is a research prototype built from draft material. It is not medical advice, and its statements still await verification against the original studies.