Component
Methionine-cycle transmethylation flux
Independently recorded entity or measured process. Linked claims specify compartment, assay and experimental scope.
1 recorded relationships. Experimental role, claim status and evidence remain attached to each record.
How nutrients influence it
Every nutrient with a recorded effect on this component, credited to the nutrient that acted rather than the chapter that recorded it. Open a nutrient to see the findings and the conditions they were measured under.
Other things that act on it
Enzymes, hormones, genes, and other components with a recorded effect. These are not nutrients, so they do not count toward the arrows above. Each finding names the chapter that recorded it.
How nutrients reach it in more than one step
Chains of two or more recorded steps that end here, grouped by the nutrient they start from. Each step is a separate finding, so a chain is a route a mechanism could take, not proof that it does.
Tracing routes…
What it does
Every recorded relationship this component is part of, grouped by its role. Plain wording comes first; the technical statement follows.
What acts on it
Mean postprandial transmethylation did not significantly change after restriction, with substantial individual variation.
Experimental context and source evidence
- availability_state
- nutrient_deficiency Imported condition classification; unverified.
- cross_nutrient
- B6 intersects methionine/folate metabolism; this experiment does not establish B12 or folate depletion.
- experimental_model
- Nine healthy adults (five women, four men; ages 20–35), repeated postprandial isotope kinetics.
- exposure
- 28 days dietary B6 restriction; plasma PLP49±4 to 19±2 nmol/L.
- limitations
- Null group means do not establish identical responses or preserved DNA methylation in every tissue.
- nutrient_topic
- Vitamin B6 research collection; topical membership is not evidence of a direct dietary effect. · Vitamin B6
- organism
- Homo sapiens
- plain_language
- Lower B6 did not make this measured process uniformly fail.
- primary_references
- [b6-lamers2011] Moderate vitamin B-6 restriction does not alter postprandial methionine cycle rates of remethylation, transmethylation, and total transsulfuration but increases the fractional synthesis rate of cystathionine in healthy young men and women (2011). https://pubmed.ncbi.nlm.nih.gov/21430249/ DOI: 10.3945/jn.110.134197
- tissue_or_cell_type
- Human blood and whole-body measurements
- trigger_kind
- nutrient_deficiency Imported condition classification; unverified.
Vitamin B6: mechanisms, deficiency and nutrient interactions (2026-09-17) · lines 1359–1370
AI-assisted literature curation; primary study URLs and scope retained in the document and extraction. Not publisher full text. · supports · Nine healthy adults (five women, four men; ages 20–35), repeated postprandial isotope kinetics. · source_derived_draft · unverified_draft
### b6-fed-transmethylation-preserved Mean postprandial transmethylation did not significantly change after restriction, with substantial individual variation. Condition category: nutrient_deficiency nutrient_topic: Vitamin B6 research collection; topical membership is not evidence of a direct dietary effect. plain_language: Lower B6 did not make this measured process uniformly fail. organism: Homo sapiens tissue_or_cell_type: Human blood and whole-body measurements experimental_model: Nine healthy adults (five women, four men; ages 20–35), repeated postprandial isotope kinetics. limitations: Null group means do not establish identical responses or preserved DNA methylation in every tissue. exposure: 28 days dietary B6 restriction; plasma PLP49±4 to 19±2 nmol/L. cross_nutrient: B6 intersects methionine/folate metabolism; this experiment does not establish B12 or folate depletion. [b6-lamers2011] Moderate vitamin B-6 restriction does not alter postprandial methionine cycle rates of remethylation, transmethylation, and total transsulfuration but increases the fractional synthesis rate of cystathionine in healthy young men and women (2011). https://pubmed.ncbi.nlm.nih.gov/21430249/ DOI: 10.3945/jn.110.134197
Complete structured claim and evidence
The events it takes part in
A mechanism often involves more than two components. These are the full events, with every participant and its role.
Situations it appears in
Low-supply and faulty-machinery situations recorded in the chapters where this component plays a part.
In the sources
Preserved passages that mention this component, quoted exactly. Open one to read it in context.
Open hypotheses
Proposed ideas that involve this component. They are labeled as hypotheses and do not change any recorded statement.
This is a research prototype built from draft material. It is not medical advice, and its statements still await verification against the original studies.