Component
Transferrin saturation
Independent substance, clinical endpoint or measured readout; study context is retained with each finding.
2 recorded relationships. Experimental role, claim status and evidence remain attached to each record.
How nutrients influence it
Every nutrient with a recorded effect on this component, credited to the nutrient that acted rather than the chapter that recorded it. Open a nutrient to see the findings and the conditions they were measured under.
Other things that act on it
Enzymes, hormones, genes, and other components with a recorded effect. These are not nutrients, so they do not count toward the arrows above. Each finding names the chapter that recorded it.
How nutrients reach it in more than one step
Chains of two or more recorded steps that end here, grouped by the nutrient they start from. Each step is a separate finding, so a chain is a route a mechanism could take, not proof that it does.
Tracing routes…
What it does
Every recorded relationship this component is part of, grouped by its role. Plain wording comes first; the technical statement follows.
What acts on it
Chromium picolinate did not alter the training-associated changes in total iron-binding capacity or transferrin saturation.
Experimental context and source evidence
- evidence_span
- {"source_cache": "artifacts/chromium-research/9322572.abstract.txt", "locator": "Exact primary indexed abstract; zero-based, end-exclusive Unicode character offsets", "file_sha256": "767fd4144862b2bbc3bf416541442924fc69da030435898b1e6843dba8e35dc8", "start_char": 0, "end_char": 1869, "text_sha256": "767fd4144862b2bbc3bf416541442924fc69da030435898b1e6843dba8e35dc8"}
- experimental_model
- Randomized double-blind supplementation with resistance training; 18 men
- exposure
- 924 µg chromium/day as picolinate versus placebo for 12 weeks; nine men/group
- limitations
- Small selected population and short follow-up. A negative result does not exclude every interaction in iron-deficient people or other exposures.
- nutrient_topic
- Chromium research collection; topical membership is not evidence of a direct dietary effect. · Chromium
- organism
- Human men aged 56–69
- plain_language
- Sharing carrier chemistry did not translate into a detectable adverse iron-transport effect in this trial.
- primary_references
- [chromium-p9322572] Chromium picolinate supplementation and resistive training by older men: effects on iron-status and hematologic indexes. (1997). https://pubmed.ncbi.nlm.nih.gov/9322572/ DOI: 10.1093/ajcn/66.4.944
- tissue_or_cell_type
- Iron-status and hematologic indices
Chromium: transport, insulin signaling, nutrient interactions and essentiality debate (2026-09-17) · lines 549–560
AI-assisted literature curation; primary study URLs and scope retained in the document and extraction. Not publisher full text. · supports · Randomized double-blind supplementation with resistance training; 18 men · source_derived_draft · unverified_draft
### chromium-human-transferrin-saturation-null Chromium picolinate did not alter the training-associated changes in total iron-binding capacity or transferrin saturation. Condition category: normal nutrient_topic: Chromium research collection; topical membership is not evidence of a direct dietary effect. plain_language: Sharing carrier chemistry did not translate into a detectable adverse iron-transport effect in this trial. organism: Human men aged 56–69 tissue_or_cell_type: Iron-status and hematologic indices experimental_model: Randomized double-blind supplementation with resistance training; 18 men limitations: Small selected population and short follow-up. A negative result does not exclude every interaction in iron-deficient people or other exposures. exposure: 924 µg chromium/day as picolinate versus placebo for 12 weeks; nine men/group evidence_span: {"source_cache": "artifacts/chromium-research/9322572.abstract.txt", "locator": "Exact primary indexed abstract; zero-based, end-exclusive Unicode character offsets", "file_sha256": "767fd4144862b2bbc3bf416541442924fc69da030435898b1e6843dba8e35dc8", "start_char": 0, "end_char": 1869, "text_sha256": "767fd4144862b2bbc3bf416541442924fc69da030435898b1e6843dba8e35dc8"} [chromium-p9322572] Chromium picolinate supplementation and resistive training by older men: effects on iron-status and hematologic indexes. (1997). https://pubmed.ncbi.nlm.nih.gov/9322572/ DOI: 10.1093/ajcn/66.4.944
Complete structured claim and evidence
Where it participates (unsigned role)
After cobalamin therapy, mean serum iron fell from 126.4 to 59.1 micrograms/dL, ferritin from 192.5 to 44.9 ng/mL and transferrin saturation from 47.2% to 17.5%.
Experimental context and source evidence
- availability_state
- nutrient_deficiency Imported condition classification; unverified.
- cross_nutrient
- B12-associated ineffective blood-cell production can complicate iron-status interpretation.
- experimental_model
- Before/after series of 75 patients diagnosed with cobalamin deficiency.
- exposure
- Blood counts and iron-status measurements before and after cobalamin therapy; regimen is not extracted from the abstract.
- limitations
- Before/after observations cannot isolate iron utilization from all other changes.
- nutrient_topic
- Vitamin B12 research collection; topical membership is not evidence of a direct dietary effect. · Vitamin B12 (cobalamins)
- organism
- Homo sapiens
- plain_language
- Restoring B12 changed how the blood iron results looked.
- primary_references
- [b12-solmaz2015] Cobalamin deficiency can mask depleted body iron reserves (2015). https://pubmed.ncbi.nlm.nih.gov/25825568/ DOI: 10.1007/s12288-014-0417-x
- tissue_or_cell_type
- Human blood or whole-person endpoints
- trigger_kind
- nutrient_deficiency Imported condition classification; unverified.
Vitamin B12: mechanisms, deficiency and nutrient interactions (2026-09-17) · lines 1585–1596
AI-assisted literature curation; primary study URLs and scope retained in the document and extraction. Not publisher full text. · supports · Before/after series of 75 patients diagnosed with cobalamin deficiency. · source_derived_draft · unverified_draft
### b12-repletion-iron-readouts After cobalamin therapy, mean serum iron fell from 126.4 to 59.1 micrograms/dL, ferritin from 192.5 to 44.9 ng/mL and transferrin saturation from 47.2% to 17.5%. Condition category: nutrient_deficiency nutrient_topic: Vitamin B12 research collection; topical membership is not evidence of a direct dietary effect. plain_language: Restoring B12 changed how the blood iron results looked. organism: Homo sapiens tissue_or_cell_type: Human blood or whole-person endpoints experimental_model: Before/after series of 75 patients diagnosed with cobalamin deficiency. limitations: Before/after observations cannot isolate iron utilization from all other changes. exposure: Blood counts and iron-status measurements before and after cobalamin therapy; regimen is not extracted from the abstract. cross_nutrient: B12-associated ineffective blood-cell production can complicate iron-status interpretation. [b12-solmaz2015] Cobalamin deficiency can mask depleted body iron reserves (2015). https://pubmed.ncbi.nlm.nih.gov/25825568/ DOI: 10.1007/s12288-014-0417-x
Complete structured claim and evidence
The events it takes part in
A mechanism often involves more than two components. These are the full events, with every participant and its role.
Situations it appears in
Low-supply and faulty-machinery situations recorded in the chapters where this component plays a part.
In the sources
Preserved passages that mention this component, quoted exactly. Open one to read it in context.
Open hypotheses
Proposed ideas that involve this component. They are labeled as hypotheses and do not change any recorded statement.
This is a research prototype built from draft material. It is not medical advice, and its statements still await verification against the original studies.