Component
Total fracture incidence
Study-defined Total fracture incidence. Read each linked record for species, exposure and endpoint.
2 recorded relationships. Experimental role, claim status and evidence remain attached to each record.
How nutrients influence it
Every nutrient with a recorded effect on this component, credited to the nutrient that acted rather than the chapter that recorded it. Open a nutrient to see the findings and the conditions they were measured under.
Other things that act on it
Enzymes, hormones, genes, and other components with a recorded effect. These are not nutrients, so they do not count toward the arrows above. Each finding names the chapter that recorded it.
How nutrients reach it in more than one step
Chains of two or more recorded steps that end here, grouped by the nutrient they start from. Each step is a separate finding, so a chain is a route a mechanism could take, not proof that it does.
Tracing routes…
What it does
Every recorded relationship this component is part of, grouped by its role. Plain wording comes first; the technical statement follows.
What acts on it
There were 171 versus 135 fractures; fracture rate ratio 1.26 (95% CI1.00–1.59; P=0.047) for annual D3 versus placebo.
Experimental context and source evidence
- cross_nutrient
- false
- experimental_model
- 2256 community-dwelling women aged≥ 70; annual-bolus randomized placebo-controlled trial
- exposure
- 500, 000 IU oral D3 each autumn/winter for 3–5 years.
- limitations
- Annual very large bolus in older women; does not demonstrate that all D3 regimens raise risk.
- nutrient_topic
- Vitamin D2 and D3 research collection; topical membership is not evidence of a direct dietary effect. · Vitamin D2 and D3
- organism
- Homo sapiens
- plain_language
- Fractures were also more frequent under that specific regimen.
- primary_references
- [sanders2010] Annual high-dose oral vitamin D and falls and fractures in older women: a randomized controlled trial. (2010). https://pubmed.ncbi.nlm.nih.gov/20460620/ DOI: 10.1001/jama.2010.594
- tissue_or_cell_type
- Clinical skeletal outcomes
Vitamin D2 and D3: mechanisms, deficiency and nutrient interactions (2026-09-17) · lines 1587–1598
AI-assisted literature curation; primary study URLs and scope retained in the document and extraction. Not publisher full text. · supports · 2256 community-dwelling women aged≥ 70; annual-bolus randomized placebo-controlled trial · source_derived_draft · unverified_draft
### vd-sanders-fractures There were 171 versus 135 fractures; fracture rate ratio 1.26 (95% CI1.00–1.59; P=0.047) for annual D3 versus placebo. Condition category: normal nutrient_topic: Vitamin D2 and D3 research collection; topical membership is not evidence of a direct dietary effect. plain_language: Fractures were also more frequent under that specific regimen. organism: Homo sapiens tissue_or_cell_type: Clinical skeletal outcomes experimental_model: 2256 community-dwelling women aged≥ 70; annual-bolus randomized placebo-controlled trial limitations: Annual very large bolus in older women; does not demonstrate that all D3 regimens raise risk. exposure: 500, 000 IU oral D3 each autumn/winter for 3–5 years. cross_nutrient: false [sanders2010] Annual high-dose oral vitamin D and falls and fractures in older women: a randomized controlled trial. (2010). https://pubmed.ncbi.nlm.nih.gov/20460620/ DOI: 10.1001/jama.2010.594
Complete structured claim and evidenceD3 assignment did not significantly reduce total fractures (HR0.98; 95% CI0.89–1.08; P=0.70).
Experimental context and source evidence
- cross_nutrient
- false
- experimental_model
- VITAL ancillary fracture trial; 25, 871 adults; median 5.3 years
- exposure
- D3 2000 IU/day versus placebo; randomized factorial omega 3 allocation; median 5.3 years.
- limitations
- Generally healthy midlife/older adults not selected for deficiency. Does not test treatment of established deficiency rickets or osteomalacia.
- nutrient_topic
- Vitamin D2 and D3 research collection; topical membership is not evidence of a direct dietary effect. · Vitamin D2 and D3
- organism
- Homo sapiens
- plain_language
- Extra D3 did not reduce this fracture endpoint in the population studied.
- primary_references
- [leboff2022] Supplemental Vitamin D and Incident Fractures in Midlife and Older Adults. (2022). https://pubmed.ncbi.nlm.nih.gov/35939577/ DOI: 10.1056/nejmoa2202106
- tissue_or_cell_type
- Clinical skeletal outcomes
Vitamin D2 and D3: mechanisms, deficiency and nutrient interactions (2026-09-17) · lines 1496–1507
AI-assisted literature curation; primary study URLs and scope retained in the document and extraction. Not publisher full text. · supports · VITAL ancillary fracture trial; 25, 871 adults; median 5.3 years · source_derived_draft · unverified_draft
### vd-vital-fracture-total D3 assignment did not significantly reduce total fractures (HR0.98; 95% CI0.89–1.08; P=0.70). Condition category: normal nutrient_topic: Vitamin D2 and D3 research collection; topical membership is not evidence of a direct dietary effect. plain_language: Extra D3 did not reduce this fracture endpoint in the population studied. organism: Homo sapiens tissue_or_cell_type: Clinical skeletal outcomes experimental_model: VITAL ancillary fracture trial; 25, 871 adults; median 5.3 years limitations: Generally healthy midlife/older adults not selected for deficiency. Does not test treatment of established deficiency rickets or osteomalacia. exposure: D3 2000 IU/day versus placebo; randomized factorial omega 3 allocation; median 5.3 years. cross_nutrient: false [leboff2022] Supplemental Vitamin D and Incident Fractures in Midlife and Older Adults. (2022). https://pubmed.ncbi.nlm.nih.gov/35939577/ DOI: 10.1056/nejmoa2202106
Complete structured claim and evidence
The events it takes part in
A mechanism often involves more than two components. These are the full events, with every participant and its role.
Situations it appears in
Low-supply and faulty-machinery situations recorded in the chapters where this component plays a part.
In the sources
Preserved passages that mention this component, quoted exactly. Open one to read it in context.
Open hypotheses
Proposed ideas that involve this component. They are labeled as hypotheses and do not change any recorded statement.
This is a research prototype built from draft material. It is not medical advice, and its statements still await verification against the original studies.