Component
Tobacco smoking
Tobacco smoking. Species, exposure and limitations are retained in each linked claim.
1 recorded relationships. Experimental role, claim status and evidence remain attached to each record.
How nutrients influence it
Every nutrient with a recorded effect on this component, credited to the nutrient that acted rather than the chapter that recorded it. Open a nutrient to see the findings and the conditions they were measured under.
Other things that act on it
Enzymes, hormones, genes, and other components with a recorded effect. These are not nutrients, so they do not count toward the arrows above. Each finding names the chapter that recorded it.
How nutrients reach it in more than one step
Chains of two or more recorded steps that end here, grouped by the nutrient they start from. Each step is a separate finding, so a chain is a route a mechanism could take, not proof that it does.
Tracing routes…
What it does
Every recorded relationship this component is part of, grouped by its role. Plain wording comes first; the technical statement follows.
Where it participates (unsigned role)
Functional variants in ADH1B and ALDH2 coupled with alcohol and smoking synergistically enhanced oesophageal cancer risk.
Experimental context and source evidence
- availability_state
- machinery_impairment Imported condition classification; unverified.
- evidence_span
- {"source_cache": "artifacts/alcohol-research/19698717.abstract.txt", "locator": "Indexed abstract; zero-based, end-exclusive Unicode character offsets", "file_sha256": "4262a0549d8e78b4e7719f62bfa61849f3cf6eb3403bf45fe28d32b7d7662c58", "start_char": 0, "end_char": 1706, "text_sha256": "4262a0549d8e78b4e7719f62bfa61849f3cf6eb3403bf45fe28d32b7d7662c58"}
- experimental_model
- Case-control study of oesophageal cancer with ADH1B and ALDH2 genotypes and smoking
- exposure
- Alcohol consumption and smoking across functional genotypes
- limitations
- A gene-environment interaction study. Synergy is reported on a statistical interaction scale, and the design is case-control.
- nutrient_topic
- Alcohol research collection; topical membership is not evidence of a direct clinical effect, and ethanol is recorded separately from the acetaldehyde it becomes. · Ethanol
- organism
- Human
- plain_language
- The variant that makes drinking unpleasant also makes each drink more carcinogenic.
- primary_references
- [alcohol-p19698717] Functional variants in ADH1B and ALDH2 coupled with alcohol and smoking synergistically enhance esophageal cancer risk. (2009). https://pubmed.ncbi.nlm.nih.gov/19698717/ DOI: 10.1053/j.gastro.2009.07.070
- tissue_or_cell_type
- Oesophagus
- trigger_kind
- machinery_impairment Imported condition classification; unverified.
Alcohol: ethanol clearance, acetaldehyde, the channels it binds, organ injury and nutrient collisions (2026-09-21) · lines 540–551
AI-assisted literature curation; primary study URLs and scope retained in the document and extraction. Not publisher full text. · supports · Case-control study of oesophageal cancer with ADH1B and ALDH2 genotypes and smoking · source_derived_draft · unverified_draft
### alcohol-genotype-cancer-synergy Functional variants in ADH1B and ALDH2 coupled with alcohol and smoking synergistically enhanced oesophageal cancer risk. Condition category: machinery_impairment nutrient_topic: Alcohol research collection; topical membership is not evidence of a direct clinical effect, and ethanol is recorded separately from the acetaldehyde it becomes. plain_language: The variant that makes drinking unpleasant also makes each drink more carcinogenic. organism: Human tissue_or_cell_type: Oesophagus experimental_model: Case-control study of oesophageal cancer with ADH1B and ALDH2 genotypes and smoking limitations: A gene-environment interaction study. Synergy is reported on a statistical interaction scale, and the design is case-control. exposure: Alcohol consumption and smoking across functional genotypes evidence_span: {"source_cache": "artifacts/alcohol-research/19698717.abstract.txt", "locator": "Indexed abstract; zero-based, end-exclusive Unicode character offsets", "file_sha256": "4262a0549d8e78b4e7719f62bfa61849f3cf6eb3403bf45fe28d32b7d7662c58", "start_char": 0, "end_char": 1706, "text_sha256": "4262a0549d8e78b4e7719f62bfa61849f3cf6eb3403bf45fe28d32b7d7662c58"} [alcohol-p19698717] Functional variants in ADH1B and ALDH2 coupled with alcohol and smoking synergistically enhance esophageal cancer risk. (2009). https://pubmed.ncbi.nlm.nih.gov/19698717/ DOI: 10.1053/j.gastro.2009.07.070
Complete structured claim and evidence
The events it takes part in
A mechanism often involves more than two components. These are the full events, with every participant and its role.
Situations it appears in
Low-supply and faulty-machinery situations recorded in the chapters where this component plays a part.
In the sources
Preserved passages that mention this component, quoted exactly. Open one to read it in context.
Open hypotheses
Proposed ideas that involve this component. They are labeled as hypotheses and do not change any recorded statement.
This is a research prototype built from draft material. It is not medical advice, and its statements still await verification against the original studies.