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Synergy is reported on a statistical interaction scale, and the design is case-control.\nexposure: Alcohol consumption and smoking across functional genotypes\nevidence_span: {\"source_cache\": \"artifacts/alcohol-research/19698717.abstract.txt\", \"locator\": \"Indexed abstract; zero-based, end-exclusive Unicode character offsets\", \"file_sha256\": \"4262a0549d8e78b4e7719f62bfa61849f3cf6eb3403bf45fe28d32b7d7662c58\", \"start_char\": 0, \"end_char\": 1706, \"text_sha256\": \"4262a0549d8e78b4e7719f62bfa61849f3cf6eb3403bf45fe28d32b7d7662c58\"}\n[alcohol-p19698717] Functional variants in ADH1B and ALDH2 coupled with alcohol and smoking synergistically enhance esophageal cancer risk. 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