Component
Human matriptase-2 / TMPRSS6
Human matriptase-2 / TMPRSS6. Species, exposure and limitations are retained in each linked claim.
1 recorded relationships. Experimental role, claim status and evidence remain attached to each record.
How nutrients influence it
Every nutrient with a recorded effect on this component, credited to the nutrient that acted rather than the chapter that recorded it. Open a nutrient to see the findings and the conditions they were measured under.
Other things that act on it
Enzymes, hormones, genes, and other components with a recorded effect. These are not nutrients, so they do not count toward the arrows above. Each finding names the chapter that recorded it.
How nutrients reach it in more than one step
Chains of two or more recorded steps that end here, grouped by the nutrient they start from. Each step is a separate finding, so a chain is a route a mechanism could take, not proof that it does.
Tracing routes…
What it does
Every recorded relationship this component is part of, grouped by its role. Plain wording comes first; the technical statement follows.
What it acts on
Germline TMPRSS6 mutations caused iron-deficiency anemia refractory to oral iron therapy in the studied families.
Experimental context and source evidence
- availability_state
- machinery_impairment Imported condition classification; unverified.
- evidence_span
- {"source_cache": "artifacts/iron-research/18408718.abstract.txt", "locator": "Exact primary indexed abstract; zero-based, end-exclusive Unicode character offsets", "file_sha256": "26d5ec56d21c4675127615cc14ef1b167eef0d8c5e2fe7d69a5b316f4e06011e", "start_char": 0, "end_char": 468, "text_sha256": "26d5ec56d21c4675127615cc14ef1b167eef0d8c5e2fe7d69a5b316f4e06011e"}
- experimental_model
- Family genetic investigation
- exposure
- Germline TMPRSS6 variants
- limitations
- Rare inherited disorder; not an explanation for every failure of oral iron.
- nutrient_topic
- Iron research collection; topical membership is not evidence of a direct dietary effect. · Iron
- organism
- Humans with refractory iron-deficiency anemia
- plain_language
- The problem can be the body’s control of iron availability, rather than simply too little iron supplied.
- primary_references
- [iron-p18408718] Mutations in TMPRSS6 cause iron-refractory iron deficiency anemia (IRIDA). (2008). https://pubmed.ncbi.nlm.nih.gov/18408718/ DOI: 10.1038/ng.130
- tissue_or_cell_type
- Systemic iron regulation
- trigger_kind
- machinery_impairment Imported condition classification; unverified.
Iron: absorption, trafficking, iron-dependent enzymes and nutrient interactions (2026-09-17) · lines 1018–1029
AI-assisted literature curation; primary study URLs and scope retained in the document and extraction. Not publisher full text. · supports · Family genetic investigation · source_derived_draft · unverified_draft
### iron-tmprss6-irida Germline TMPRSS6 mutations caused iron-deficiency anemia refractory to oral iron therapy in the studied families. Condition category: machinery_impairment nutrient_topic: Iron research collection; topical membership is not evidence of a direct dietary effect. plain_language: The problem can be the body’s control of iron availability, rather than simply too little iron supplied. organism: Humans with refractory iron-deficiency anemia tissue_or_cell_type: Systemic iron regulation experimental_model: Family genetic investigation limitations: Rare inherited disorder; not an explanation for every failure of oral iron. exposure: Germline TMPRSS6 variants evidence_span: {"source_cache": "artifacts/iron-research/18408718.abstract.txt", "locator": "Exact primary indexed abstract; zero-based, end-exclusive Unicode character offsets", "file_sha256": "26d5ec56d21c4675127615cc14ef1b167eef0d8c5e2fe7d69a5b316f4e06011e", "start_char": 0, "end_char": 468, "text_sha256": "26d5ec56d21c4675127615cc14ef1b167eef0d8c5e2fe7d69a5b316f4e06011e"} [iron-p18408718] Mutations in TMPRSS6 cause iron-refractory iron deficiency anemia (IRIDA). (2008). https://pubmed.ncbi.nlm.nih.gov/18408718/ DOI: 10.1038/ng.130
Complete structured claim and evidence
The events it takes part in
A mechanism often involves more than two components. These are the full events, with every participant and its role.
Situations it appears in
Low-supply and faulty-machinery situations recorded in the chapters where this component plays a part.
In the sources
Preserved passages that mention this component, quoted exactly. Open one to read it in context.
Open hypotheses
Proposed ideas that involve this component. They are labeled as hypotheses and do not change any recorded statement.
This is a research prototype built from draft material. It is not medical advice, and its statements still await verification against the original studies.