Component
Tin-mesoporphyrin IX, a heme oxygenase-1 inhibitor
Tin-mesoporphyrin IX, a heme oxygenase-1 inhibitor. Species, exposure and limitations are retained in each linked claim.
1 recorded relationships. Experimental role, claim status and evidence remain attached to each record.
How nutrients influence it
Every nutrient with a recorded effect on this component, credited to the nutrient that acted rather than the chapter that recorded it. Open a nutrient to see the findings and the conditions they were measured under.
Other things that act on it
Enzymes, hormones, genes, and other components with a recorded effect. These are not nutrients, so they do not count toward the arrows above. Each finding names the chapter that recorded it.
How nutrients reach it in more than one step
Chains of two or more recorded steps that end here, grouped by the nutrient they start from. Each step is a separate finding, so a chain is a route a mechanism could take, not proof that it does.
Tracing routes…
What it does
Every recorded relationship this component is part of, grouped by its role. Plain wording comes first; the technical statement follows.
What it acts on
Treatment with the specific heme oxygenase-1 inhibitor tin-mesoporphyrin IX led to complete abrogation of the hyperbaric-oxygen-induced adaptive protection in human lymphocytes, and the time course of induction paralleled the development of protection.
Experimental context and source evidence
- availability_state
- machinery_impairment Imported condition classification; unverified.
- evidence_span
- {"source_cache": "artifacts/hbot-research/11751428.abstract.txt", "locator": "Indexed abstract; zero-based, end-exclusive Unicode character offsets", "file_sha256": "d8fb2631feb55cff2514149c0935ad25230bbdc520cc82dddaec2baa4ada40f3", "start_char": 0, "end_char": 1641, "text_sha256": "d8fb2631feb55cff2514149c0935ad25230bbdc520cc82dddaec2baa4ada40f3"}
- experimental_model
- Isolated human lymphocytes exposed in vitro with a specific heme oxygenase-1 inhibitor
- exposure
- Hyperbaric oxygen in vitro, 2 hours at 3 bar; tin-mesoporphyrin IX
- limitations
- An inhibitor experiment that establishes requirement in this cell system. The authors state the exact mechanism by which the enzyme protects remains to be elucidated.
- nutrient_topic
- Hyperbaric oxygen research collection; topical membership is not evidence of a direct clinical effect, and a therapeutic exposure is not a dietary intake. · Hyperbaric oxygen therapy
- organism
- Human lymphocytes and V79 cells
- plain_language
- Block that one enzyme and the protection disappears.
- primary_references
- [hbot-p11751428] Involvement of heme oxygenase-1 (HO-1) in the adaptive protection of human lymphocytes after hyperbaric oxygen (HBO) treatment. (2001). https://pubmed.ncbi.nlm.nih.gov/11751428/ DOI: 10.1093/carcin/22.12.1979
- tissue_or_cell_type
- Isolated lymphocytes
- trigger_kind
- machinery_impairment Imported condition classification; unverified.
Hyperbaric oxygen: the exposure, its reactive species, the signals they carry, and the nutrient-dependent enzymes that handle them (2026-09-19) · lines 335–346
AI-assisted literature curation; primary study URLs and scope retained in the document and extraction. Not publisher full text. · supports · Isolated human lymphocytes exposed in vitro with a specific heme oxygenase-1 inhibitor · source_derived_draft · unverified_draft
### hbot-ho1-required Treatment with the specific heme oxygenase-1 inhibitor tin-mesoporphyrin IX led to complete abrogation of the hyperbaric-oxygen-induced adaptive protection in human lymphocytes, and the time course of induction paralleled the development of protection. Condition category: machinery_impairment nutrient_topic: Hyperbaric oxygen research collection; topical membership is not evidence of a direct clinical effect, and a therapeutic exposure is not a dietary intake. plain_language: Block that one enzyme and the protection disappears. organism: Human lymphocytes and V79 cells tissue_or_cell_type: Isolated lymphocytes experimental_model: Isolated human lymphocytes exposed in vitro with a specific heme oxygenase-1 inhibitor limitations: An inhibitor experiment that establishes requirement in this cell system. The authors state the exact mechanism by which the enzyme protects remains to be elucidated. exposure: Hyperbaric oxygen in vitro, 2 hours at 3 bar; tin-mesoporphyrin IX evidence_span: {"source_cache": "artifacts/hbot-research/11751428.abstract.txt", "locator": "Indexed abstract; zero-based, end-exclusive Unicode character offsets", "file_sha256": "d8fb2631feb55cff2514149c0935ad25230bbdc520cc82dddaec2baa4ada40f3", "start_char": 0, "end_char": 1641, "text_sha256": "d8fb2631feb55cff2514149c0935ad25230bbdc520cc82dddaec2baa4ada40f3"} [hbot-p11751428] Involvement of heme oxygenase-1 (HO-1) in the adaptive protection of human lymphocytes after hyperbaric oxygen (HBO) treatment. (2001). https://pubmed.ncbi.nlm.nih.gov/11751428/ DOI: 10.1093/carcin/22.12.1979
Complete structured claim and evidence
The events it takes part in
A mechanism often involves more than two components. These are the full events, with every participant and its role.
Situations it appears in
Low-supply and faulty-machinery situations recorded in the chapters where this component plays a part.
In the sources
Preserved passages that mention this component, quoted exactly. Open one to read it in context.
Open hypotheses
Proposed ideas that involve this component. They are labeled as hypotheses and do not change any recorded statement.
This is a research prototype built from draft material. It is not medical advice, and its statements still await verification against the original studies.