Component
Thiamine phosphate ester hydrolysis
Enzymatic cleavage of phosphate groups from phosphorylated thiamine forms.
1 recorded relationships. Experimental role, claim status and evidence remain attached to each record.
How nutrients influence it
Every nutrient with a recorded effect on this component, credited to the nutrient that acted rather than the chapter that recorded it. Open a nutrient to see the findings and the conditions they were measured under.
Other things that act on it
Enzymes, hormones, genes, and other components with a recorded effect. These are not nutrients, so they do not count toward the arrows above. Each finding names the chapter that recorded it.
How nutrients reach it in more than one step
Chains of two or more recorded steps that end here, grouped by the nutrient they start from. Each step is a separate finding, so a chain is a route a mechanism could take, not proof that it does.
Tracing routes…
What it does
Every recorded relationship this component is part of, grouped by its role. Plain wording comes first; the technical statement follows.
What acts on it
Calf intestinal alkaline phosphatase hydrolyzed ThDP and ThMP; ThDP had 53-fold higher Vmax/Km under the tested conditions.
Experimental context and source evidence
- evidence-scope
- Purified intestinal enzyme
- evidence_locator
- Abstract
- evidence_spans
- [{"source_document": "artifacts/thiamine_transport_sources/vovk-2002-phosphatase-source-record.json", "source_field": "resultList.result[0].abstractText", "start_char": 0, "end_char": 828}]
- experimental_model
- Calf intestinal alkaline phosphatase; pH 8.5, 30 C; substrate kinetics.
- limitations
- Purified bovine enzyme; does not quantify human meal absorption.
- nutrient_topic
- Thiamine research collection; topical membership is not evidence of a direct dietary effect. · Thiamine (vitamin B1)
- organism
- Bos taurus
- plain_language
- An intestinal enzyme can remove B1 phosphate groups; the two forms react at different rates.
- primary_references
- [vovk-2002-phosphatase] [Relative reactivity of thiamine monophosphate and thiamine diphosphate upon interaction with alkaline phosphatase] (2002). https://pubmed.ncbi.nlm.nih.gov/12199107/
- tissue_or_cell_type
- Purified intestinal enzyme
Thiamine: mechanisms, deficiency and nutrient interactions (2026-09-17) · lines 106–118
AI-assisted literature curation; primary study URLs and scope retained in the document and extraction. Not publisher full text. · supports · Calf intestinal alkaline phosphatase; pH 8.5, 30 C; substrate kinetics. · source_derived_draft · unverified_draft
### b1-phosphate-ester-hydrolysis Calf intestinal alkaline phosphatase hydrolyzed ThDP and ThMP; ThDP had 53-fold higher Vmax/Km under the tested conditions. Condition category: normal nutrient_topic: Thiamine research collection; topical membership is not evidence of a direct dietary effect. plain_language: An intestinal enzyme can remove B1 phosphate groups; the two forms react at different rates. organism: Bos taurus tissue_or_cell_type: Purified intestinal enzyme experimental_model: Calf intestinal alkaline phosphatase; pH 8.5, 30 C; substrate kinetics. limitations: Purified bovine enzyme; does not quantify human meal absorption. evidence_spans: [{"source_document": "artifacts/thiamine_transport_sources/vovk-2002-phosphatase-source-record.json", "source_field": "resultList.result[0].abstractText", "start_char": 0, "end_char": 828}] evidence_locator: Abstract evidence-scope: Purified intestinal enzyme [vovk-2002-phosphatase] [Relative reactivity of thiamine monophosphate and thiamine diphosphate upon interaction with alkaline phosphatase] (2002). https://pubmed.ncbi.nlm.nih.gov/12199107/
Complete structured claim and evidence
The events it takes part in
A mechanism often involves more than two components. These are the full events, with every participant and its role.
Situations it appears in
Low-supply and faulty-machinery situations recorded in the chapters where this component plays a part.
In the sources
Preserved passages that mention this component, quoted exactly. Open one to read it in context.
Open hypotheses
Proposed ideas that involve this component. They are labeled as hypotheses and do not change any recorded statement.
This is a research prototype built from draft material. It is not medical advice, and its statements still await verification against the original studies.