L-Theanine plus L-arginine, study-specific combination: molecular mechanisms & dependencies

How nutrients influence it

Every nutrient with a recorded effect on this component, credited to the nutrient that acted rather than the chapter that recorded it. Open a nutrient to see the findings and the conditions they were measured under.

Human evidence only

How nutrients reach it in more than one step

Chains of two or more recorded steps that end here, grouped by the nutrient they start from. Each step is a separate finding, so a chain is a route a mechanism could take, not proof that it does.

Tracing routes…

What it does

Every recorded relationship this component is part of, grouped by its role. Plain wording comes first; the technical statement follows.

Recorded relationships

What it acts on

Adding 50 mg arginine did not significantly improve the stress marker compared with 200 mg theanine alone.
L-Theanine plus L-arginine, study-specific combination → Salivary alpha-amylase stress response source_derived_draftungraded
Experimental context and source evidence
evidence_span
{"source_cache": "artifacts/theanine-research/36596553.abstract.txt", "locator": "Primary indexed abstract; zero-based, end-exclusive Unicode character offsets", "file_sha256": "d932aa2f599868e52419cee62048a12b929d575cbb78c95645195083668ea245", "start_char": 0, "end_char": 1550, "text_sha256": "d932aa2f599868e52419cee62048a12b929d575cbb78c95645195083668ea245"}
experimental_model
Randomized three-arm placebo-controlled stress trial
exposure
200 mg theanine; 200 mg theanine plus 50 mg arginine; placebo
limitations
Short stress challenge. Both active arms differed from placebo, but combination versus theanine alone did not (p=0.74); no established synergy.
nutrient_topic
L-Theanine research collection; topical membership is not evidence of a direct dietary effect. · L-Theanine
organism
120 healthy young adults
plain_language
A numerical difference between active groups did not establish an added benefit.
primary_references
[theanine-p36596553] Effect of Combined Ingestion of L-Theanine and L-Arginine for Short-Term Psychological Stress in Young Adults: A Randomized Placebo-Controlled Study. (2022). https://pubmed.ncbi.nlm.nih.gov/36596553/ DOI: 10.3177/jnsv.68.540
tissue_or_cell_type
Salivary alpha-amylase after mental stress
L-Theanine: metabolism, neural signaling, nutrient connections and human outcomes (2026-09-17) · lines 926–937
AI-assisted literature curation; primary study URLs and scope retained in the document and extraction. Not publisher full text. · supports · Randomized three-arm placebo-controlled stress trial · source_derived_draft · unverified_draft
### theanine-arginine-no-added-benefit Adding 50 mg arginine did not significantly improve the stress marker compared with 200 mg theanine alone. Condition category: normal nutrient_topic: L-Theanine research collection; topical membership is not evidence of a direct dietary effect. plain_language: A numerical difference between active groups did not establish an added benefit. organism: 120 healthy young adults tissue_or_cell_type: Salivary alpha-amylase after mental stress experimental_model: Randomized three-arm placebo-controlled stress trial limitations: Short stress challenge. Both active arms differed from placebo, but combination versus theanine alone did not (p=0.74); no established synergy. exposure: 200 mg theanine; 200 mg theanine plus 50 mg arginine; placebo evidence_span: {"source_cache": "artifacts/theanine-research/36596553.abstract.txt", "locator": "Primary indexed abstract; zero-based, end-exclusive Unicode character offsets", "file_sha256": "d932aa2f599868e52419cee62048a12b929d575cbb78c95645195083668ea245", "start_char": 0, "end_char": 1550, "text_sha256": "d932aa2f599868e52419cee62048a12b929d575cbb78c95645195083668ea245"} [theanine-p36596553] Effect of Combined Ingestion of L-Theanine and L-Arginine for Short-Term Psychological Stress in Young Adults: A Randomized Placebo-Controlled Study. (2022). https://pubmed.ncbi.nlm.nih.gov/36596553/ DOI: 10.3177/jnsv.68.540
Complete structured claim and evidence
The active arm had a smaller salivary alpha-amylase change 15 minutes after stress than placebo.
L-Theanine plus L-arginine, study-specific combination → Salivary alpha-amylase stress response source_derived_draftungraded
Experimental context and source evidence
evidence_span
{"source_cache": "artifacts/theanine-research/36596553.abstract.txt", "locator": "Primary indexed abstract; zero-based, end-exclusive Unicode character offsets", "file_sha256": "d932aa2f599868e52419cee62048a12b929d575cbb78c95645195083668ea245", "start_char": 0, "end_char": 1550, "text_sha256": "d932aa2f599868e52419cee62048a12b929d575cbb78c95645195083668ea245"}
experimental_model
Randomized three-arm placebo-controlled stress trial
exposure
200 mg theanine; 200 mg theanine plus 50 mg arginine; placebo
limitations
Short stress challenge. Both active arms differed from placebo, but combination versus theanine alone did not (p=0.74); no established synergy.
nutrient_topic
L-Theanine research collection; topical membership is not evidence of a direct dietary effect. · L-Theanine
organism
120 healthy young adults
plain_language
This is a measured stress marker, not proof of treatment for an anxiety disorder.
primary_references
[theanine-p36596553] Effect of Combined Ingestion of L-Theanine and L-Arginine for Short-Term Psychological Stress in Young Adults: A Randomized Placebo-Controlled Study. (2022). https://pubmed.ncbi.nlm.nih.gov/36596553/ DOI: 10.3177/jnsv.68.540
tissue_or_cell_type
Salivary alpha-amylase after mental stress
L-Theanine: metabolism, neural signaling, nutrient connections and human outcomes (2026-09-17) · lines 913–924
AI-assisted literature curation; primary study URLs and scope retained in the document and extraction. Not publisher full text. · supports · Randomized three-arm placebo-controlled stress trial · source_derived_draft · unverified_draft
### theanine-stress-arginine The active arm had a smaller salivary alpha-amylase change 15 minutes after stress than placebo. Condition category: normal nutrient_topic: L-Theanine research collection; topical membership is not evidence of a direct dietary effect. plain_language: This is a measured stress marker, not proof of treatment for an anxiety disorder. organism: 120 healthy young adults tissue_or_cell_type: Salivary alpha-amylase after mental stress experimental_model: Randomized three-arm placebo-controlled stress trial limitations: Short stress challenge. Both active arms differed from placebo, but combination versus theanine alone did not (p=0.74); no established synergy. exposure: 200 mg theanine; 200 mg theanine plus 50 mg arginine; placebo evidence_span: {"source_cache": "artifacts/theanine-research/36596553.abstract.txt", "locator": "Primary indexed abstract; zero-based, end-exclusive Unicode character offsets", "file_sha256": "d932aa2f599868e52419cee62048a12b929d575cbb78c95645195083668ea245", "start_char": 0, "end_char": 1550, "text_sha256": "d932aa2f599868e52419cee62048a12b929d575cbb78c95645195083668ea245"} [theanine-p36596553] Effect of Combined Ingestion of L-Theanine and L-Arginine for Short-Term Psychological Stress in Young Adults: A Randomized Placebo-Controlled Study. (2022). https://pubmed.ncbi.nlm.nih.gov/36596553/ DOI: 10.3177/jnsv.68.540
Complete structured claim and evidence

The events it takes part in

A mechanism often involves more than two components. These are the full events, with every participant and its role.

Situations it appears in

Low-supply and faulty-machinery situations recorded in the chapters where this component plays a part.

In the sources

Preserved passages that mention this component, quoted exactly. Open one to read it in context.

Open hypotheses

Proposed ideas that involve this component. They are labeled as hypotheses and do not change any recorded statement.

This is a research prototype built from draft material. It is not medical advice, and its statements still await verification against the original studies.

L-Theanine plus L-arginine, study-specific combination