Component
Thyroglobulin-bound dehydroalanyl residues
Residual dehydroalanine side chains covalently retained in TG after hormonogenic coupling; distinct from free metabolites.
1 recorded relationships. Experimental role, claim status and evidence remain attached to each record.
How nutrients influence it
Every nutrient with a recorded effect on this component, credited to the nutrient that acted rather than the chapter that recorded it. Open a nutrient to see the findings and the conditions they were measured under.
Other things that act on it
Enzymes, hormones, genes, and other components with a recorded effect. These are not nutrients, so they do not count toward the arrows above. Each finding names the chapter that recorded it.
How nutrients reach it in more than one step
Chains of two or more recorded steps that end here, grouped by the nutrient they start from. Each step is a separate finding, so a chain is a route a mechanism could take, not proof that it does.
Tracing routes…
What it does
Every recorded relationship this component is part of, grouped by its role. Plain wording comes first; the technical statement follows.
What acts on it
During TPO-catalyzed hormone formation in TG, approximately one protein-bound dehydroalanine residue was formed per hormone residue.
Experimental context and source evidence
- cross_nutrient
- false
- evidence_span
- {"source_cache": "artifacts/iodine-synthesis-sources/7372636.txt", "start_char": 1081, "end_char": 2101, "text_sha256": "5ea5287db6f28391150ad5b783a0be5e450fd71f22b92028fefb7900c686c636", "text_characters": 1020, "note": "Exact publisher passage retained in the cited local source cache; locator and digest supplied here."}
- experimental_model
- Purified hog TPO with human goiter TG or tyrosine-radiolabeled hog TG; chromatographic hormone and dehydroalanine analyses
- exposure
- Hog TPO with human goiter TG and radiolabeled hog TG; dehydroalanine quantified after benzyl-mercaptan addition or borohydride reduction and hydrolysis.
- limitations
- Chemical trapping identifies the retained donor remnant; it does not prove every proposed radical intermediate or identify individual T3 donor sites.
- nutrient_topic
- Iodine research collection; topical membership is not evidence of a direct dietary effect. · Iodine
- organism
- Sus scrofa enzyme; Homo sapiens and Sus scrofa TG in separate experiments
- plain_language
- Coupling leaves a dehydroalanine remnant on the donor side of TG while creating a hormone residue.
- primary_references
- [iodine-syn-tpo-coupling1980] Formation of dehydroalanine residues during thyroid hormone synthesis in thyroglobulin. (1980). https://pubmed.ncbi.nlm.nih.gov/7372636/ DOI: 10.1016/S0021-9258(19)70782-0
- tissue_or_cell_type
- Purified-protein reactions
Iodine: thyroid hormone production, deficiency, excess and nutrient interactions (2026-09-17) · lines 870–882
AI-assisted literature curation; primary study URLs and scope retained in the document and extraction. Not publisher full text. · supports · Purified hog TPO with human goiter TG or tyrosine-radiolabeled hog TG; chromatographic hormone and dehydroalanine analyses · source_derived_draft · unverified_draft
### iodine-syn-coupling-dehydroalanine During TPO-catalyzed hormone formation in TG, approximately one protein-bound dehydroalanine residue was formed per hormone residue. Condition category: normal nutrient_topic: Iodine research collection; topical membership is not evidence of a direct dietary effect. plain_language: Coupling leaves a dehydroalanine remnant on the donor side of TG while creating a hormone residue. organism: Sus scrofa enzyme; Homo sapiens and Sus scrofa TG in separate experiments tissue_or_cell_type: Purified-protein reactions experimental_model: Purified hog TPO with human goiter TG or tyrosine-radiolabeled hog TG; chromatographic hormone and dehydroalanine analyses limitations: Chemical trapping identifies the retained donor remnant; it does not prove every proposed radical intermediate or identify individual T3 donor sites. exposure: Hog TPO with human goiter TG and radiolabeled hog TG; dehydroalanine quantified after benzyl-mercaptan addition or borohydride reduction and hydrolysis. cross_nutrient: false evidence_span: {"source_cache": "artifacts/iodine-synthesis-sources/7372636.txt", "start_char": 1081, "end_char": 2101, "text_sha256": "5ea5287db6f28391150ad5b783a0be5e450fd71f22b92028fefb7900c686c636", "text_characters": 1020, "note": "Exact publisher passage retained in the cited local source cache; locator and digest supplied here."} [iodine-syn-tpo-coupling1980] Formation of dehydroalanine residues during thyroid hormone synthesis in thyroglobulin. (1980). https://pubmed.ncbi.nlm.nih.gov/7372636/ DOI: 10.1016/S0021-9258(19)70782-0
Complete structured claim and evidence
The events it takes part in
A mechanism often involves more than two components. These are the full events, with every participant and its role.
Situations it appears in
Low-supply and faulty-machinery situations recorded in the chapters where this component plays a part.
In the sources
Preserved passages that mention this component, quoted exactly. Open one to read it in context.
Open hypotheses
Proposed ideas that involve this component. They are labeled as hypotheses and do not change any recorded statement.
This is a research prototype built from draft material. It is not medical advice, and its statements still await verification against the original studies.