Component
Plasma tadalafil exposure
Circulating tadalafil concentration and its decline over time.
2 recorded relationships. Experimental role, claim status and evidence remain attached to each record.
How nutrients influence it
Every nutrient with a recorded effect on this component, credited to the nutrient that acted rather than the chapter that recorded it. Open a nutrient to see the findings and the conditions they were measured under.
Other things that act on it
Enzymes, hormones, genes, and other components with a recorded effect. These are not nutrients, so they do not count toward the arrows above. Each finding names the chapter that recorded it.
How nutrients reach it in more than one step
Chains of two or more recorded steps that end here, grouped by the nutrient they start from. Each step is a separate finding, so a chain is a route a mechanism could take, not proof that it does.
Tracing routes…
What it does
Every recorded relationship this component is part of, grouped by its role. Plain wording comes first; the technical statement follows.
What acts on it
Tadalafil plasma concentrations declined nearly monoexponentially with a mean half-life of 17.5 hours, with 5th and 95th percentiles of 11.5 and 29.6 hours.
Experimental context and source evidence
- duration
- Single dose and 10 days
- evidence_access
- Primary PubMed abstract and indexed metadata reviewed. Full-text method details not stated here remain unresolved.
- experimental_model
- 237 healthy subjects across 13 clinical pharmacology studies, with a separate multiple-dose study
- exposure
- Single 2.5 to 20 mg doses, and 10 or 20 mg once daily for 10 days
- limitations
- Healthy subjects only. No clinically meaningful effect of body mass index, age, gender or smoking was identified, and food had negligible effect on bioavailability.
- organism
- 237 healthy subjects across 13 clinical pharmacology studies, with a separate multiple-dose study
- plain_language
- Tadalafil plasma concentrations declined nearly monoexponentially with a mean half-life of 17.5 hours, with 5th and 95th percentiles of 11.5 and 29.6 hours.
- primary_references
- Tadalafil pharmacokinetics in healthy subjects. (2006). https://pubmed.ncbi.nlm.nih.gov/16487221/ DOI: 10.1111/j.1365-2125.2005.02553.x
- route
- Oral
- tissue
- Plasma tadalafil pharmacokinetics
Tadalafil: PDE5 occupancy, the cGMP route and three measured endpoints (2026-09-22) · lines 78–87
Original AI-assisted curation of seven primary studies resolved by PubMed title search, with every abstract read and all DOIs cross-checked against live PubMed metadata. Two references carry an unresolvable erratum and are recorded as corrected. Study-specific doses, effect sizes and limitations retained. Not publisher full text. · supports · · source_derived_draft · unverified_draft
## tadalafil-half-life Tadalafil plasma concentrations declined nearly monoexponentially with a mean half-life of 17.5 hours, with 5th and 95th percentiles of 11.5 and 29.6 hours. Model/species: 237 healthy subjects across 13 clinical pharmacology studies, with a separate multiple-dose study Tissue/system: Plasma tadalafil pharmacokinetics Exposure: Single 2.5 to 20 mg doses, and 10 or 20 mg once daily for 10 days Route: Oral Duration: Single dose and 10 days Limits: Healthy subjects only. No clinically meaningful effect of body mass index, age, gender or smoking was identified, and food had negligible effect on bioavailability. Primary reference: Tadalafil pharmacokinetics in healthy subjects. (2006). https://pubmed.ncbi.nlm.nih.gov/16487221/ DOI: 10.1111/j.1365-2125.2005.02553.x Access: Primary PubMed abstract and indexed metadata reviewed. Full-text method details not stated here remain unresolved.
Complete structured claim and evidence
Where it participates (unsigned role)
After tadalafil, sublingual nitroglycerin lowered standing systolic blood pressure below 85 mmHg in more subjects than after placebo at 4, 8 and 24 hours, with no difference at 48, 72 and 96 hours.
Experimental context and source evidence
- duration
- Measured to 96 hours after the last tadalafil dose
- evidence_access
- Primary PubMed abstract and indexed metadata reviewed. Full-text method details not stated here remain unresolved.
- experimental_model
- 150 male subjects, randomised crossover with a 10 to 21 day washout
- exposure
- Seven consecutive daily doses of tadalafil 20 mg or placebo, then repeated sublingual nitroglycerin 0.4 mg
- limitations
- A pharmacodynamic interaction study in male volunteers using a fixed 20 mg dose; the time course reported here describes when the interaction was detectable, not a dosing instruction.
- organism
- 150 male subjects, randomised crossover with a 10 to 21 day washout
- plain_language
- After tadalafil, sublingual nitroglycerin lowered standing systolic blood pressure below 85 mmHg in more subjects than after placebo at 4, 8 and 24 hours, with no difference at 48, 72 and 96 hours.
- primary_references
- Time course of the interaction between tadalafil and nitrates. (2003). https://pubmed.ncbi.nlm.nih.gov/14642699/ DOI: 10.1016/j.jacc.2003.09.023
- route
- Oral tadalafil with sublingual nitroglycerin
- tissue
- Standing systolic and diastolic blood pressure after a nitrate
Tadalafil: PDE5 occupancy, the cGMP route and three measured endpoints (2026-09-22) · lines 89–98
Original AI-assisted curation of seven primary studies resolved by PubMed title search, with every abstract read and all DOIs cross-checked against live PubMed metadata. Two references carry an unresolvable erratum and are recorded as corrected. Study-specific doses, effect sizes and limitations retained. Not publisher full text. · supports · · source_derived_draft · unverified_draft
## tadalafil-augments-the-nitrate-blood-pressure-fall After tadalafil, sublingual nitroglycerin lowered standing systolic blood pressure below 85 mmHg in more subjects than after placebo at 4, 8 and 24 hours, with no difference at 48, 72 and 96 hours. Model/species: 150 male subjects, randomised crossover with a 10 to 21 day washout Tissue/system: Standing systolic and diastolic blood pressure after a nitrate Exposure: Seven consecutive daily doses of tadalafil 20 mg or placebo, then repeated sublingual nitroglycerin 0.4 mg Route: Oral tadalafil with sublingual nitroglycerin Duration: Measured to 96 hours after the last tadalafil dose Limits: A pharmacodynamic interaction study in male volunteers using a fixed 20 mg dose; the time course reported here describes when the interaction was detectable, not a dosing instruction. Primary reference: Time course of the interaction between tadalafil and nitrates. (2003). https://pubmed.ncbi.nlm.nih.gov/14642699/ DOI: 10.1016/j.jacc.2003.09.023 Access: Primary PubMed abstract and indexed metadata reviewed. Full-text method details not stated here remain unresolved.
Complete structured claim and evidence
The events it takes part in
A mechanism often involves more than two components. These are the full events, with every participant and its role.
Situations it appears in
Low-supply and faulty-machinery situations recorded in the chapters where this component plays a part.
In the sources
Preserved passages that mention this component, quoted exactly. Open one to read it in context.
Open hypotheses
Proposed ideas that involve this component. They are labeled as hypotheses and do not change any recorded statement.
This is a research prototype built from draft material. It is not medical advice, and its statements still await verification against the original studies.