Component
G1 arrest and apoptosis in T24 bladder-cancer cells
Species, preparation, dose and limitations are retained on linked claims.
1 recorded relationships. Experimental role, claim status and evidence remain attached to each record.
How nutrients influence it
Every nutrient with a recorded effect on this component, credited to the nutrient that acted rather than the chapter that recorded it. Open a nutrient to see the findings and the conditions they were measured under.
Other things that act on it
Enzymes, hormones, genes, and other components with a recorded effect. These are not nutrients, so they do not count toward the arrows above. Each finding names the chapter that recorded it.
How nutrients reach it in more than one step
Chains of two or more recorded steps that end here, grouped by the nutrient they start from. Each step is a separate finding, so a chain is a route a mechanism could take, not proof that it does.
Tracing routes…
What it does
Every recorded relationship this component is part of, grouped by its role. Plain wording comes first; the technical statement follows.
What acts on it
Purified annonacin activated p21, increased Bax and caspase-3, and produced G1 arrest and cell death in cultured T24 bladder-cancer cells.
Experimental context and source evidence
- dose
- Purified annonacin concentration-response
- duration
- Up to 48 hours
- evidence_access
- Primary PubMed abstract and indexed metadata reviewed. Full-text method details not stated here remain unresolved.
- evidence_scope
- literature_reviewed; model-specific source-derived curation
- experimental_model
- Human T24 bladder-cancer cells and other cancer lines
- limitations
- Cancer-cell cytotoxicity does not establish tumor selectivity, human efficacy, or a safe graviola product.
- nutrient_topic
- Graviola (Annona muricata) chapter; interacting nutrients, drugs, peptides and proteins retain their experimental settings. · Graviola / Annona muricata
- organism
- Human T24 bladder-cancer cells and other cancer lines
- plain_language
- Purified annonacin activated p21, increased Bax and caspase-3, and produced G1 arrest and cell death in cultured T24 bladder-cancer cells.
- primary_references
- Annonacin, a mono-tetrahydrofuran acetogenin, arrests cancer cells at the G1 phase and causes cytotoxicity in a Bax- and caspase-3-related pathway. (2003). https://pubmed.ncbi.nlm.nih.gov/12697268/ DOI: 10.1016/s0024-3205(03)00190-5
- route
- In vitro
- tissue
- Cell cycle and apoptosis markers
Graviola (Annona muricata): mechanism of action and interactions (2026-09-20) · lines 99–108
Original AI-assisted source-specific curation with primary-study citations, model, exposure, route, duration, negative findings and limitations preserved. Not publisher full text. · supports · Human T24 bladder-cancer cells and other cancer lines · source_derived_draft · unverified_draft
## graviola-annonacin-cell-cycle Purified annonacin activated p21, increased Bax and caspase-3, and produced G1 arrest and cell death in cultured T24 bladder-cancer cells. Model/species: Human T24 bladder-cancer cells and other cancer lines Tissue/system: Cell cycle and apoptosis markers Exposure: Purified annonacin concentration-response Route: In vitro Duration: Up to 48 hours Limits: Cancer-cell cytotoxicity does not establish tumor selectivity, human efficacy, or a safe graviola product. Primary reference: Annonacin, a mono-tetrahydrofuran acetogenin, arrests cancer cells at the G1 phase and causes cytotoxicity in a Bax- and caspase-3-related pathway. (2003). https://pubmed.ncbi.nlm.nih.gov/12697268/ DOI: 10.1016/s0024-3205(03)00190-5 Access: Primary PubMed abstract and indexed metadata reviewed. Full-text method details not stated here remain unresolved.
Complete structured claim and evidence
The events it takes part in
A mechanism often involves more than two components. These are the full events, with every participant and its role.
Situations it appears in
Low-supply and faulty-machinery situations recorded in the chapters where this component plays a part.
In the sources
Preserved passages that mention this component, quoted exactly. Open one to read it in context.
Open hypotheses
Proposed ideas that involve this component. They are labeled as hypotheses and do not change any recorded statement.
This is a research prototype built from draft material. It is not medical advice, and its statements still await verification against the original studies.