Component
Low-voltage-activated T-type voltage-dependent calcium channels
Low-voltage-activated T-type voltage-dependent calcium channels. Species, exposure and limitations are retained in each linked claim.
1 recorded relationships. Experimental role, claim status and evidence remain attached to each record.
How nutrients influence it
Every nutrient with a recorded effect on this component, credited to the nutrient that acted rather than the chapter that recorded it. Open a nutrient to see the findings and the conditions they were measured under.
Other things that act on it
Enzymes, hormones, genes, and other components with a recorded effect. These are not nutrients, so they do not count toward the arrows above. Each finding names the chapter that recorded it.
How nutrients reach it in more than one step
Chains of two or more recorded steps that end here, grouped by the nutrient they start from. Each step is a separate finding, so a chain is a route a mechanism could take, not proof that it does.
Tracing routes…
What it does
Every recorded relationship this component is part of, grouped by its role. Plain wording comes first; the technical statement follows.
What acts on it
Capsaicin, dihydrocapsaicin, N-VAMC8, N-VAMC9 and N-VAMC10 directly and partially reversibly inhibited low-voltage-activated T-type calcium channels, whereas olvanil, capsiate and vanillylamine could not, and the capsaicin inhibition of T-type channels was independent of TRPV1 activation.
Experimental context and source evidence
- evidence_span
- {"source_cache": "artifacts/dihydrocapsaicin-research/17362879.abstract.txt", "locator": "Indexed abstract; zero-based, end-exclusive Unicode character offsets", "file_sha256": "7e28fe88d1e616cf4d60ccadcf38ae9b0890891513dcda0d9623e5d3579d7201", "start_char": 0, "end_char": 1243, "text_sha256": "7e28fe88d1e616cf4d60ccadcf38ae9b0890891513dcda0d9623e5d3579d7201"}
- experimental_model
- Enzymatically synthesised capsaicin analogues applied to voltage-dependent calcium channels
- exposure
- Capsaicin, dihydrocapsaicin, N-VAMC8, N-VAMC9, N-VAMC10, olvanil, capsiate and vanillylamine on T-type channels
- limitations
- A second TRPV1-independent target, with a clear structural boundary: the ester analogue and the free amine do not do it. The channel work is in isolated preparations.
- nutrient_topic
- Dihydrocapsaicin research collection; topical membership is not evidence of a direct clinical effect, and dihydrocapsaicin is recorded separately from capsaicin. · Dihydrocapsaicin
- organism
- Sensory neuron preparations
- plain_language
- Both compounds shut down a second kind of calcium channel in pain neurons, again without the receptor.
- primary_references
- [dhc-p17362879] Enzymatic synthesis of capsaicin analogs and their effect on the T-type Ca2+ channels. (2007). https://pubmed.ncbi.nlm.nih.gov/17362879/ DOI: 10.1016/j.bbrc.2007.02.144
- tissue_or_cell_type
- Primary sensory neurons
AI-assisted literature curation; primary study URLs and scope retained in the document and extraction. Not publisher full text. · supports · Enzymatically synthesised capsaicin analogues applied to voltage-dependent calcium channels · source_derived_draft · unverified_draft
### dhc-t-type-inhibition Capsaicin, dihydrocapsaicin, N-VAMC8, N-VAMC9 and N-VAMC10 directly and partially reversibly inhibited low-voltage-activated T-type calcium channels, whereas olvanil, capsiate and vanillylamine could not, and the capsaicin inhibition of T-type channels was independent of TRPV1 activation. Condition category: normal nutrient_topic: Dihydrocapsaicin research collection; topical membership is not evidence of a direct clinical effect, and dihydrocapsaicin is recorded separately from capsaicin. plain_language: Both compounds shut down a second kind of calcium channel in pain neurons, again without the receptor. organism: Sensory neuron preparations tissue_or_cell_type: Primary sensory neurons experimental_model: Enzymatically synthesised capsaicin analogues applied to voltage-dependent calcium channels limitations: A second TRPV1-independent target, with a clear structural boundary: the ester analogue and the free amine do not do it. The channel work is in isolated preparations. exposure: Capsaicin, dihydrocapsaicin, N-VAMC8, N-VAMC9, N-VAMC10, olvanil, capsiate and vanillylamine on T-type channels evidence_span: {"source_cache": "artifacts/dihydrocapsaicin-research/17362879.abstract.txt", "locator": "Indexed abstract; zero-based, end-exclusive Unicode character offsets", "file_sha256": "7e28fe88d1e616cf4d60ccadcf38ae9b0890891513dcda0d9623e5d3579d7201", "start_char": 0, "end_char": 1243, "text_sha256": "7e28fe88d1e616cf4d60ccadcf38ae9b0890891513dcda0d9623e5d3579d7201"} [dhc-p17362879] Enzymatic synthesis of capsaicin analogs and their effect on the T-type Ca2+ channels. (2007). https://pubmed.ncbi.nlm.nih.gov/17362879/ DOI: 10.1016/j.bbrc.2007.02.144
Complete structured claim and evidence
The events it takes part in
A mechanism often involves more than two components. These are the full events, with every participant and its role.
Situations it appears in
Low-supply and faulty-machinery situations recorded in the chapters where this component plays a part.
In the sources
Preserved passages that mention this component, quoted exactly. Open one to read it in context.
Open hypotheses
Proposed ideas that involve this component. They are labeled as hypotheses and do not change any recorded statement.
This is a research prototype built from draft material. It is not medical advice, and its statements still await verification against the original studies.